Navigation Links
Clues point to cause of a rare fat-distribution disease
Date:3/20/2013

Studying a protein that gives structure to the nucleus of cells, Johns Hopkins researchers stumbled upon mutations associated with familial partial lipodystrophy (FPLD), a rare disease that disrupts normal patterns of fat distribution throughout the body.

"Our findings open new paths for learning how and why fat cells are disproportionately affected by mutations in the protein lamin A, which is found in the nucleus of most cells of the body," says Katherine Wilson, Ph.D., professor of cell biology at the Johns Hopkins University School of Medicine.

According to the researchers, this is the first report that another protein, SUMO1, can attach to lamin A. Importantly, they found that FPLD-causing mutations in lamin A prevent this attachment. Details of the study were published in the Feb. 1 issue of the journal Molecular Biology of the Cell.

Wilson says lamin A is primarily known for giving shape to the nucleus. "It forms networks of strong 'cables' at the nuclear membrane and works with other proteins to create and maintain the three-dimensional environment in which chromosomes are properly organized, protected and expressed," she says.

When the Wilson group made their discovery, they were studying lamin A binding to another protein, actin. Actin can sometimes form a complex with certain SUMO proteins, small proteins often attached to other proteins to alter their functions, their locations and their interactions with additional proteins.

"Sometimes you go into an experiment looking for one thing but you find another," says Wilson. "We wanted to know if lamin A could bind to actin-SUMO1 complexes. Instead, we found that SUMO1 itself attaches to lamin A."

SUMO1 is usually attached to proteins at sites with certain properties; these sites can be predicted by the surrounding amino acids, the basic building blocks of proteins whose blueprints are found in genes. So the researchers searched lamin A's a
'/>"/>

Contact: Catherine Kolf
ckolf@jhmi.edu
443-287-2251
Johns Hopkins Medicine
Source:Eurekalert

Page: 1 2

Related biology news :

1. Clues to chromosome crossovers
2. USC researchers find possible genetic clues to organ development, birth defects
3. Climate change clues from tiny marine algae -- ancient and modern
4. The genome of diamondback moth provides new clues for sustainable pest management
5. Heat-resistant corals provide clues to climate change survival
6. New findings in the search for genetic clues to insulin production
7. Unraveling the threads: Simplest cotton genome offers clues for fiber improvements
8. Emerging virus in raccoons may provide cancer clues
9. Mining ancient ores for clues to early life
10. Genome decoded: Scientists find clues to more disease-resistant watermelons
11. Watching the developing brain, scientists glean clues on neurological disorder
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/30/2014)... treatment has been shown to relieve patients, pain. ... transmission between the peripheral and central nervous systems, ... Radiation Medicine, Chinese Academy of Medical Sciences, China ... dorsal root ganglia (DRG) to provide relief for ... 14.8, 29.6 MBq) were implanted separately into the ...
(Date:7/30/2014)... SAN JOSE, Calif. , July 30, 2014 ... industry-academia partnership with the United States Air Force ... project proposed by Binghamton ... for human performance monitoring (HPM). The $425,000 project, ... and electronics packaging firm i3 Electronics, Inc. ( ...
(Date:7/29/2014)... USA The advanced optical methods and applications for ... a revolution in the neurosciences were the inspiration behind ... SPIE, the international society for optics and photonics. , ... BRAIN Initiative in the United States, and a special ... and provide examples of the impact that optics and ...
Breaking Biology News(10 mins):Nano-Bio Manufacturing Consortium Awards Funding to Binghamton University for Development of Electronics and Biometric Sensor Platforms 2Nano-Bio Manufacturing Consortium Awards Funding to Binghamton University for Development of Electronics and Biometric Sensor Platforms 3SPIE launches Neurophotonics journal with special section on BRAIN Initiative 2SPIE launches Neurophotonics journal with special section on BRAIN Initiative 3
... availability of fossil fuels stimulates the search for different ... the alternatives. Sugars derived from the grain of agricultural ... crops occupy fertile soils needed for food and feed ... various grass residues such as corn stover and sugarcane ...
... frogs to humans, selecting a mate is complicated. Females ... health or parenting potential. But it can be difficult for ... In a study of gray tree frogs, a ... males whose calls reflect the ability to multitask effectively. ...
... 15, 2013 A team of investigators systematically analyzed the ... in a rigorous and controlled study of postmenopausal women. They ... symptoms reported by the participants. Their results are published in ... . The influence of low calcium and vitamin D ...
Cached Biology News:New possibilities for efficient biofuel production 2New possibilities for efficient biofuel production 3Female frogs prefer males who can multitask 2Calcium plus vitamin D supplementation does not reduce joint symptoms in postmenopausal women 2
(Date:7/29/2014)... , July 29, 2014   Sequenom, Inc. ... company that provides innovative genetic analysis solutions, and ... esoteric laboratory services in the United States ... prenatal testing patents and applications. "We have ... and patient care, and we welcome the opportunity to ...
(Date:7/29/2014)... separated from its properties? On July 29, the prestigious ... the first Cheshire Cat experiment, separating a neutron from ... CA, and Vienna University of Technology. , Chesire Cat"Well! ... Alice in Wonderland, "but a grin without a cat! ... my life!" Alice,s surprise stems from her experience that ...
(Date:7/29/2014)... created a new way of manufacturing microstructured surfaces ... by self-assembly of carbon nanotubes, could exhibit a ... stiffness and strength, or the ability to repel ... demonstrated that mechanical forces can be used to ... that we can independently control the mechanical ...
(Date:7/29/2014)... -- Pomerantz LLP is investigating claims on behalf of investors ... IPXL).  Such investors are advised to contact Robert ... ext. 237. The investigation concerns whether Impax ... Sections 10(b) and 20(a) of the Securities Exchange Act ... Impax Laboratories, Inc. (the "Company") issued a press release ...
Breaking Biology Technology:Sequenom Enters Into License Agreement With Mayo Medical Laboratories 2Sequenom Enters Into License Agreement With Mayo Medical Laboratories 3Sequenom Enters Into License Agreement With Mayo Medical Laboratories 4The quantum Cheshire cat: Scientists separate a particle from its properties 2The quantum Cheshire cat: Scientists separate a particle from its properties 3The quantum Cheshire cat: Scientists separate a particle from its properties 4A new way to make microstructured surfaces 2SHAREHOLDER ALERT: Pomerantz Law Firm Investigates Claims On Behalf of Investors of Impax Laboratories, Inc. - IPXL 2
... , , , , , ... that are specific for that mRNA sequence. The primer design should also , ... product derived from contaminating genomic DNA. There are two approaches , ... , , , , , ...
... , , , , , Kit for PCR and PCR carry-over , ... , , , Catalog Number, ... 1585541, 1 kit (50 PCR and UNG reactions), ... Special Interest Sites , , Innovative , ...
... , , For isolating genomic nucleic , acids for PCR, restriction enzyme analysis, and ... , , Catalog Number, ... 1796828, 1 kit (100 purifications), ... Special Interest Sites, , Nucleic , ...
Cached Biology Technology:
MiniCycler thermal cycler with Hot Bonnet heated lid, holds 25x0.2ml tubes...
... Radiant Red fluorescent RNA stain is used ... (formaldehyde or glyoxal) agarose gels and does ... with a 302 nm transilluminator, the stain ... photographed on Polaroid film or with a ...
... mitochondrial transmembrane potential is one ... that occur following induction of ... Kit utilizes a lipophilic cation, ... mitochondrial activity marker. MitoLight partitions ...
... The Hepta adaptor for the PDS-1000 He ... be transformed than the standard system. It fits ... system, where it splits the helium shock wave ... gold or tungsten particles over this larger area, ...
Biology Products: