Navigation Links
Clues point to cause of a rare fat-distribution disease
Date:3/20/2013

Studying a protein that gives structure to the nucleus of cells, Johns Hopkins researchers stumbled upon mutations associated with familial partial lipodystrophy (FPLD), a rare disease that disrupts normal patterns of fat distribution throughout the body.

"Our findings open new paths for learning how and why fat cells are disproportionately affected by mutations in the protein lamin A, which is found in the nucleus of most cells of the body," says Katherine Wilson, Ph.D., professor of cell biology at the Johns Hopkins University School of Medicine.

According to the researchers, this is the first report that another protein, SUMO1, can attach to lamin A. Importantly, they found that FPLD-causing mutations in lamin A prevent this attachment. Details of the study were published in the Feb. 1 issue of the journal Molecular Biology of the Cell.

Wilson says lamin A is primarily known for giving shape to the nucleus. "It forms networks of strong 'cables' at the nuclear membrane and works with other proteins to create and maintain the three-dimensional environment in which chromosomes are properly organized, protected and expressed," she says.

When the Wilson group made their discovery, they were studying lamin A binding to another protein, actin. Actin can sometimes form a complex with certain SUMO proteins, small proteins often attached to other proteins to alter their functions, their locations and their interactions with additional proteins.

"Sometimes you go into an experiment looking for one thing but you find another," says Wilson. "We wanted to know if lamin A could bind to actin-SUMO1 complexes. Instead, we found that SUMO1 itself attaches to lamin A."

SUMO1 is usually attached to proteins at sites with certain properties; these sites can be predicted by the surrounding amino acids, the basic building blocks of proteins whose blueprints are found in genes. So the researchers searched lamin A's a
'/>"/>

Contact: Catherine Kolf
ckolf@jhmi.edu
443-287-2251
Johns Hopkins Medicine
Source:Eurekalert

Page: 1 2

Related biology news :

1. Clues to chromosome crossovers
2. USC researchers find possible genetic clues to organ development, birth defects
3. Climate change clues from tiny marine algae -- ancient and modern
4. The genome of diamondback moth provides new clues for sustainable pest management
5. Heat-resistant corals provide clues to climate change survival
6. New findings in the search for genetic clues to insulin production
7. Unraveling the threads: Simplest cotton genome offers clues for fiber improvements
8. Emerging virus in raccoons may provide cancer clues
9. Mining ancient ores for clues to early life
10. Genome decoded: Scientists find clues to more disease-resistant watermelons
11. Watching the developing brain, scientists glean clues on neurological disorder
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/17/2015)... Conn. , Aug. 17, 2015  NXT-ID, Inc. ... biometric authentication company focused on the growing mobile commerce ... its new sales campaign for Q4 2015. The new ... marketing team consisting of Amplitude Marketing Group ( http://amplitudemarketing.com/ ... Marketing Group is a leader in retail driven marketing ...
(Date:8/12/2015)... , Aug. 12, 2015  Synaptics Inc. (NASDAQ: ... interface solutions, today announced that four of its ... solution, have officially been named FIDO Certified™ by ... of the certification, Synaptics, Natural ID™ fingerprint solutions ... Authentication Framework (UAF) standard and are interoperable among ...
(Date:8/6/2015)... Calif. , Aug. 6, 2015  Today, ... will visit Crossmatch ™ to learn firsthand ... and protect data. Crossmatch is a world leader ... technologies and expertise are helping federal agencies and ... and security.   "The vast majority ...
Breaking Biology News(10 mins):NXT-ID, Inc. Launches Sales Campaign for Wocket Smart Wallet with Award Winning Marketing Team 2NXT-ID, Inc. Launches Sales Campaign for Wocket Smart Wallet with Award Winning Marketing Team 3Synaptics Announces FIDO Certification of Natural ID Fingerprint Solutions 2Synaptics Announces FIDO Certification of Natural ID Fingerprint Solutions 3Rep. Honda to Visit Crossmatch in Redwood City 2
... Dec. 20, 2012 UT Southwestern Medical Center ... the heart,s ability to regenerate, a critical step toward ... attack. Cardiologists and molecular biologists at UT Southwestern, ... regenerates, found that microRNAs tiny strands that regulate ...
... easiest and fastest way to test for harmful Escherichia ... in Frontiers in Microbiology on the 20th of December, she ... to discover specific gene targets that indicate the presence of ... this PCR system are rapid, sensitive, and reliable. ...
... may be your first choice for assistance with most ... researchers at the Johns Hopkins Bloomberg School of Public ... the best health care professionals to give weight related ... causes of and solutions to obesity care and identified ...
Cached Biology News:Research pinpoints key gene for regenerating cells after heart attack 2USDA explores using novel genetic labs for faster detection of E. coli 2Physicians admit feeling under qualified and lacking necessary education to treat obesity 2
(Date:8/28/2015)... - RepliCel Life Sciences Inc. (OTCQB: REPCF) (TSXV: ... the development of autologous cell therapies, today reported ... 2015, corporate highlights, and near-term milestones.  The company,s ... www.sedar.com ,  www.edgar.com and at ... to launch its RCS-01 treatment for aging and ...
(Date:8/27/2015)... , ... August 27, 2015 , ... ... for venture capital funds, investment firms and animal health companies to hear from ... raised $160 million. Several have also received licensing agreements or distribution contracts. ...
(Date:8/27/2015)... 2015 /PRNewswire/ - Portage Biotech Inc. ("Portage") (OTC ... Pharmaceutical Holding Company Limited (Biohaven), announced today that ... of BHV-0223, a glutamate modulating agent. Biohaven filed ... recently obtained clearance from the U.S. Food and ... Portage holds 54% equity interest in Biohaven, a ...
(Date:8/27/2015)... ON , Aug. 27, 2015 /PRNewswire/ - BIOREM Inc. (TSXV: ... three and six-month periods ended June 30, 2015. Biorem,s complete second ... www.sedar.com ). FINANCIAL HIGHLIGHTS: in ,000,s except earnings per shareThree-months ... , 2014 , 2015 , 2014 ... 9,398 , 4,433 Gross profit , 1,656 ...
Breaking Biology Technology:RepliCel Reports Second Quarter 2015 Financial Results 2RepliCel Reports Second Quarter 2015 Financial Results 3RepliCel Reports Second Quarter 2015 Financial Results 4RepliCel Reports Second Quarter 2015 Financial Results 5VetStem Biopharma, Inc. Among Seventeen Companies Selected to Present at the KC Animal Health Investment Forum on September 1st 2015 2VetStem Biopharma, Inc. Among Seventeen Companies Selected to Present at the KC Animal Health Investment Forum on September 1st 2015 3Portage's Biohaven doses first human subject in Phase 1 trial with lead drug candidate BHV-0223 2Portage's Biohaven doses first human subject in Phase 1 trial with lead drug candidate BHV-0223 3Portage's Biohaven doses first human subject in Phase 1 trial with lead drug candidate BHV-0223 4BIOREM Reports $718,000 Net Earnings for the Second Quarter 2BIOREM Reports $718,000 Net Earnings for the Second Quarter 3
... Kuros Biosurgery AG, a biotechnology company focused ... for trauma, wound and spinal indications,announced today the ... Patent Office. This now allowed patent,application is a ... patents designed to protect Kuros’ synthetic biomaterial,(matrix) technologies ...
... (June 17, 2011)--A team of researchers has proposed a way ... to control the flow of electrons with a laser "on-off ... It,s a layer of carbon atoms only one-atom thick, but ... well and heat better than any other known material. It ...
... Calif., June 17, 2011 Pharmacyclics, Inc. (Nasdaq: ... into stock purchase agreements with various institutional investors and ... its common stock in a registered direct offering at ... 2011.  Gross proceeds of the offering, before deducting expenses, ...
Cached Biology Technology:Kuros Announces Allowance of European Patent for Synthetic Biomaterials 2Kuros Announces Allowance of European Patent for Synthetic Biomaterials 3Graphene may gain an 'on-off switch,' adding semiconductor to long list of material's achievements 2Pharmacyclics Announces Results of Registered Direct Offering 2Pharmacyclics Announces Results of Registered Direct Offering 3
The large Dodeca stainer shaking rack holds the staining trays in the large Dodeca stainer....
...
...
... Quansys Biosciences Q-Plex Array is a new ... human, mouse, and rat research. The Q-Plex ... ELISA-based test where 4 distinct capture antibodies ... a 96-well plate in a defined array. ...
Biology Products: