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Closer to detecting preeclampsia
Date:3/17/2014

ssociated with increases in very low density lipoprotein (VLDL) fats and cholesterol for the preeclamptic women, and also reflected an increased stress response and inflammation in preeclampsia.

The metabolic profiles show that the metabolism of pregnant women is highly affected by preeclampsia. It is possible that the metabolism may be changed even earlier, before the diagnostic events (hypertension and proteinuria) appear. If the changes can be detected as early as the first trimester, it may be possible to prevent some of the women from developing the disease, leading to healthier mothers and children.

The study is a collaboration between the Research Group of Inflammation and Genetics in Pregnancy, and the MR Cancer group. The group used NMR spectroscopy to characterize biofluids using the magnetic properties of atoms. The method is called metabolomics the study of low molecular weight metabolites. Metabolites are intermediates and end processes of the chemical interactions in the body that are necessary for life.

The next project for the group is to use the same method to analyze samples from women in early pregnancy, for possible prediction of the disease.


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Contact: Marie Austdal
marie.austdal@ntnu.no
47-957-05482
Norwegian University of Science and Technology
Source:Eurekalert

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