Identifying biomarkers could lead to earlier detection of preeclampsia, which in turn can lead to healthier mothers and children, according to a collaborative study from the Centre of Molecular Inflammation Research (CEMIR) and the MR Cancer Group at the Norwegian University of Science and Technology (NTNU). Their findings, "Metabolomic Biomarkers in Serum and Urine in Women with Preeclampsia," will be published in PLOS ONE on 17 March.
"We have found that the metabolism in women who experience preeclampsia is clearly different from women with normal pregnancies. The differences suggest that preeclampsia has a similar profile to cardiovascular disease, and the inflammatory processes are reflected in the blood and urine of affected women. This abnormal metabolism may be present earlier, so that the disease may be predicted before onset," says Marie Austdal, a PhD candidate at NTNU, and first author of the study.
Preeclampsia is a disease of pregnancy that has its origins in insufficient development of the placenta during the first trimester, but usually only presents itself close to term, causing high blood pressure (hypertension) and proteins in the urine (proteinuria) of the affected women. The syndrome can be dangerous for both mother and unborn child, causing preterm birth and restrictions in fetal growth, along with an increased risk of cardiovascular disease later in life for both. Preeclampsia is thought to be related to an exaggerated immune response from the beginning of pregnancy.
The researchers found a set of biomarkers in urine and serum samples that were different between women with preeclampsia, women with normal pregnancies and women who were not pregnant. These biomarkers tell the story of what is happening to the metabolism of these women when they have developed the disease.
There was a clear and significant difference in the metabolomic profile of all three groups of women. The differences could be a
|Contact: Marie Austdal|
Norwegian University of Science and Technology