Navigation Links
Closer to detecting preeclampsia
Date:3/17/2014

Identifying biomarkers could lead to earlier detection of preeclampsia, which in turn can lead to healthier mothers and children, according to a collaborative study from the Centre of Molecular Inflammation Research (CEMIR) and the MR Cancer Group at the Norwegian University of Science and Technology (NTNU). Their findings, "Metabolomic Biomarkers in Serum and Urine in Women with Preeclampsia," will be published in PLOS ONE on 17 March.

"We have found that the metabolism in women who experience preeclampsia is clearly different from women with normal pregnancies. The differences suggest that preeclampsia has a similar profile to cardiovascular disease, and the inflammatory processes are reflected in the blood and urine of affected women. This abnormal metabolism may be present earlier, so that the disease may be predicted before onset," says Marie Austdal, a PhD candidate at NTNU, and first author of the study.

Preeclampsia is a disease of pregnancy that has its origins in insufficient development of the placenta during the first trimester, but usually only presents itself close to term, causing high blood pressure (hypertension) and proteins in the urine (proteinuria) of the affected women. The syndrome can be dangerous for both mother and unborn child, causing preterm birth and restrictions in fetal growth, along with an increased risk of cardiovascular disease later in life for both. Preeclampsia is thought to be related to an exaggerated immune response from the beginning of pregnancy.

The researchers found a set of biomarkers in urine and serum samples that were different between women with preeclampsia, women with normal pregnancies and women who were not pregnant. These biomarkers tell the story of what is happening to the metabolism of these women when they have developed the disease.

There was a clear and significant difference in the metabolomic profile of all three groups of women. The differences could be associated with increases in very low density lipoprotein (VLDL) fats and cholesterol for the preeclamptic women, and also reflected an increased stress response and inflammation in preeclampsia.

The metabolic profiles show that the metabolism of pregnant women is highly affected by preeclampsia. It is possible that the metabolism may be changed even earlier, before the diagnostic events (hypertension and proteinuria) appear. If the changes can be detected as early as the first trimester, it may be possible to prevent some of the women from developing the disease, leading to healthier mothers and children.

The study is a collaboration between the Research Group of Inflammation and Genetics in Pregnancy, and the MR Cancer group. The group used NMR spectroscopy to characterize biofluids using the magnetic properties of atoms. The method is called metabolomics the study of low molecular weight metabolites. Metabolites are intermediates and end processes of the chemical interactions in the body that are necessary for life.

The next project for the group is to use the same method to analyze samples from women in early pregnancy, for possible prediction of the disease.


'/>"/>

Contact: Marie Austdal
marie.austdal@ntnu.no
47-957-05482
Norwegian University of Science and Technology
Source:Eurekalert

Related biology news :

1. U of Alberta researcher steps closer to understand autoimmune diseases
2. Synthetic diamond steps closer to next generation of high performance electrochemical applications
3. Pilot Results Move GHX Closer to Delivery of Healthcare Industrys First Implantable Device Supply Chain Solution
4. Oil from algae closer to reality through studies by unique collaboration of scientists
5. Are we closer to understanding the cause of deadly sepsis?
6. Another muscular dystrophy mystery solved; MU scientists inch closer to a therapy for patients
7. A closer look at chromosomes
8. Biosensor that detects antibiotic resistance brings us one step closer to fighting superbugs
9. Scientists closer to universal flu vaccine after pandemic natural experiment
10. Detecting breast cancers fingerprint in a droplet of blood
11. By detecting smallest virus, researchers open possibilities for early disease detection
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/9/2016)... , UAE, May 9, 2016 ... it comes to expanding freedom for high net worth ... Even in today,s globally connected world, there is still ... system could ever duplicate sealing your deal with a ... second passports by taking advantage of citizenship via investment ...
(Date:4/26/2016)... India and LONDON ... Infosys Finacle, part of EdgeVerve Systems, a product ... and Onegini today announced a partnership to integrate ... solutions.      (Logo: http://photos.prnewswire.com/prnh/20151104/283829LOGO ... to provide their customers enhanced security to access ...
(Date:4/15/2016)... Research and Markets has announced ... 2016-2020,"  report to their offering.  , ... global gait biometrics market is expected to grow ... 2016-2020. Gait analysis generates multiple variables ... to compute factors that are not or cannot ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... ... 23, 2016 , ... UAS LifeSciences, one of the leading ... UP4™ Probiotics, into Target stores nationwide. The company, which has been manufacturing high ... its list of well-respected retailers. This list includes such fine stores as Whole ...
(Date:6/23/2016)... , June 23, 2016 /PRNewswire/ - FACIT has ... Ontario biotechnology company, Propellon Therapeutics Inc. ... and commercialization of a portfolio of first-in-class WDR5 ... targets such as WDR5 represent an exciting class ... in precision medicine for cancer patients. Substantial advances ...
(Date:6/23/2016)... , June 23, 2016 Houston ... with the Cy-Fair Sports Association to serve as ... the agreement, Houston Methodist Willowbrook will provide sponsorship ... and connectivity with association coaches, volunteers, athletes and ... with the Cy-Fair Sports Association and to bring ...
(Date:6/23/2016)... June 23, 2016  The Prostate Cancer Foundation (PCF) is pleased ... and faster cures for prostate cancer. Members of the Class of 2016 were ... Read More About the Class of 2016 PCF Young ... ... ...
Breaking Biology Technology: