Navigation Links
Closer look at cell membrane shows cholesterol 'keeping order'
Date:3/31/2011

Cell membranes form the "skin" of most every cell in your body, but the ability to view them up close and in motion cannot be rendered by many experimental techniques. A team of scientists working at the National Institute of Standards and Technology (NIST) and University of California, Irvine, recently developed a way to magnify them dramatically. Their work has helped illuminate the important role of cholesterol within this boundary between the cell and the outside world.

The multi-institutional team used tools at the NIST Center for Neutron Research (NCNR) to examine the membrane at more than 1,000 times the resolution offered by an optical microscopethe equivalent of magnifying the point of a needle to the size of a large building. This enabled an unprecedented look at the membrane, whichbecause it controls access to our cellsis a major target for many drugs.

"Drugs that affect pain sensation, heart rhythm, mood, appetite and memory all target proteins lodged in the cell membrane that function like little gates," says Ella Mihailescu of the Institute for Bioscience and Biotechnology Research, a joint institute of NIST and the University of Maryland. "Because membranes and their proteins are important to medicine, we would like a better picture of how the membrane functionsand not just a better snapshot. We want to see it move, as it does constantly in real life."

Optical microscopes offer limited resolution, while the more powerful electron microscopes require freezing samples before they can be magnified. But by using neutron diffraction, which does not require frozen subjects, the team not only observed the membrane more closely and in motion, but they also gained insight into the long-known phenomenon of the membrane growing thicker and stiffer in the presence of cholesterol.

These lipid chains form a two-layer skin with the "heads" of the lipids facing outward toward the cell's exterior and interior and the "t
'/>"/>

Contact: Chad Boutin
boutin@nist.gov
301-975-4261
National Institute of Standards and Technology (NIST)
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Getting closer to a better biocontrol for garden pests
2. Study shows hunger hitting closer to home
3. Stem cell therapy for age-related macular degeneration -- a step closer to reality
4. Researchers step closer to treatment of virulent hospital infection
5. Breakthrough on cystic fibrosis 1 step closer as new research alliance formed
6. Methane-powered laptops may be closer than you think
7. Myth of a germ-free world: A closer look at antimicrobial products
8. New clinical test to predict lupus flares moves closer to the market
9. Scientists closer to grasping how the brains hearing center spurs responses to sound
10. 1 step closer to a drug treatment for cystic fibrosis, MU professor says
11. Plant scientists move closer to making any crop drought-tolerant
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Closer look at cell membrane shows cholesterol 'keeping order'
(Date:7/11/2014)... Brazil- In the brains of all vertebrates, information ... an electric or chemical signal to be passed ... which are the most abundant type of synapse, ... is crucial for learning, memory, perception and cognition, ... critical for brain function. For instance, every ...
(Date:7/10/2014)... , June 27, 2014  The American ... National Institute of Standards and Technology (NIST) and ... its academic research and forensic science expert members ... Board is an element of the NIST,s Organization ... are among the first appointments made to the ...
(Date:7/10/2014)... June 30, 2014  Aware, Inc. (NASDAQ: ... services, previously announced on June 26, 2014 that its ... of $1.75 per share, or approximately $40 million in ... 10, 2014 and a payment date of July 24, ... it had set an ex-dividend date for this special ...
Breaking Biology News(10 mins):Blame it on the astrocytes 2Ten Members of the American Academy of Forensic Sciences Appointed to Forensic Science Standards Board (FSSB) 2Ten Members of the American Academy of Forensic Sciences Appointed to Forensic Science Standards Board (FSSB) 3NASDAQ Sets Ex-Dividend Date for Aware, Inc.'s Special Cash Dividend of $1.75 Per Share 2
... raise a finger without your brain directing muscle cells, and ... well. A neuron sends a message, or neurotransmitter, to ... get the message, the receiving cell must have a receptor. ... receptor so it,s properly positioned to catch the message. ...
... gene that may confer susceptibility to pulmonary tuberculosis has ... and their collaborators in The Netherlands, Indonesia, United Kingdom, ... j PLoS Genetics , the scientists report that ... had been previously shown to recognize some factors from ...
... A new tool for investigating the rice genome has ... Pamela Ronald, professor of plant pathology. The inexpensive, publicly-available ... in the rice genome. Details are published this week ... In higher organisms, such as humans or rice plants, ...
Cached Biology News:Stabilizing force for good communication between neurons and muscle cells found 2Gene with probable role in human susceptibility to pulmonary tuberculosis identified 2
(Date:7/10/2014)... 10, 2014   Ceres, Inc . (Nasdaq: ... announced today financial results for the three months ended ... business. Ceres reported that the company and ... this growing season in Brazil, which concluded in June, ... sorghum evaluation areas for part of the growing season. ...
(Date:7/10/2014)... Using microscopic polymer light resonators that expand ... MIT,s Quantum Photonics Laboratory have developed new optical ... range. Optical sensors are ideal for detecting trace ... compact, lightweight nature, and immunity to electromagnetic interference. ... developed before, the MIT team conceived an extremely ...
(Date:7/10/2014)... quantum Hall effect in bilayer graphene and shown that ... an electric field. , The fractional quantum Hall ... sheets are exposed to large magnetic fields, is a ... electrons behave as a single system. However, while the ... details of this collective behavior remain not well understood, ...
(Date:7/10/2014)... for crude 3-D glasses, polarized glasses, and shutter ... devices, used to trick the brain into perceiving ... obsolete with the introduction of new holography technology ... doctoral students Yuval Yifat, Michal Eitan, and Zeev ... nanoantennas that could be used for security as ...
Breaking Biology Technology:Ceres Announces Fiscal Third Quarter 2014 Financial Results 2Ceres Announces Fiscal Third Quarter 2014 Financial Results 3Ceres Announces Fiscal Third Quarter 2014 Financial Results 4Ceres Announces Fiscal Third Quarter 2014 Financial Results 5Ceres Announces Fiscal Third Quarter 2014 Financial Results 6Ceres Announces Fiscal Third Quarter 2014 Financial Results 7Ceres Announces Fiscal Third Quarter 2014 Financial Results 8Ceres Announces Fiscal Third Quarter 2014 Financial Results 9Swell new sensors 2Columbia researchers observe tunable quantum behavior in bilayer graphene 2Columbia researchers observe tunable quantum behavior in bilayer graphene 3Projecting a 3-dimensional future 2Projecting a 3-dimensional future 3
... Microchip,Biotechnologies, Inc. (MBI) is pleased to announce that ... Biodiversity Institute of Ontario,University of Guelph, will be ... for the Apollo 100 STAR System. The Apollo ... system for DNA sample preparation for,sequencing. The System ...
... Remergent Skincare Line, FREEPORT, N.Y., April 8, ... the development and sale of skincare,products utilizing DNA ... investment round led by existing investor Trevi Health ... new capital is being used to fund the ...
... 8 Amsterdam,Molecular Therapeutics (Euronext: AMT), a leader in ... part of the newly created Next Biotech Index of,NYSE ... our company,for this index," said Ronald Lorijn, CEO of ... companies and will help investors to track,the performance of ...
Cached Biology Technology:Canadian Centre for DNA Barcoding to Participate in Microchip Biotechnologies Early Access Program for Microchip-Based DNA Sample Preparation and Cycle Sequencing 2Amsterdam Molecular Therapeutics Part of Next Biotech Index 2
IKKbeta/IKK-2 Polyclonal Antibody 100 ug affinity purified rabbit polyclonal antibody. Reacts with human. Tested in Western blotting....
1, 2 or 8 PreMixes are included as part of the FailSafe™ PCR System....
The Hybrid Hunter Yeast Two-Hybrid System uses the activation of reporter genes to indicate positive protein-protein interactions. Two reporters are used an auxotrophic marker and lacZ....
Sprague Dawley rats, 7-8 weeks of age, mixed gender; collected by exsanguination in Alsever's solution at 1:2 dilution...
Biology Products: