Navigation Links
Close up look at a microbial vaccination program
Date:9/22/2011

A complex of proteins in the bacterium E.coli that plays a critical role in defending the microbe from viruses and other invaders has been discovered to have the shape of a seahorse by researchers with the U.S Department of Energy's Lawrence Berkeley National Laboratory (Berkeley Lab). This discovery holds far more implications for your own health than you might think.

In its never-ending battle to protect you from infections by bacteria, viruses, toxins and other invasive elements, your immune system has an important ally many allies in fact. By the time you reach adulthood, some 90-percent of the cells in your body are microbial. These microbes collectively known as the microbiome play a critical role in preserving the health of their human host.

"Perturbations of the human microbiome by viral and other infections can disrupt important symbioses and open the door to invasions by human pathogens," says Blake Wiedenheft, a biochemist with Berkeley Lab and the University of California (UC) Berkeley. "By understanding the mechanisms behind microbial immune systems, we can better understand how they are similar and where they are different from the human immune system."

Wiedenheft is part of a team of researchers, led by biochemist Jennifer Doudna, a leading authority on RNA molecular structures, and biophysicist Eva Nogales, an expert on electron microscopy and image analysis, that has provided the first sub-nanometer look at a central player in the microbial immune system. Through a combination of cryo-electron microscopy and three-dimensional image reconstruction, they have determined the structure of a protein complex called "Cascade," that acts as a surveillance system for detecting and inactivating the nucleic acid of invading pathogens.

Doudna and Nogales are the corresponding authors and Wiedenheft and Gabriel Lander are the lead authors of a paper describing this research in the journal Nature. The
'/>"/>

Contact: Lynn Yarris
lcyarris@lbl.gov
510-486-5375
DOE/Lawrence Berkeley National Laboratory
Source:Eurekalert  

Page: 1 2 3 4

Related biology news :

1. New threat closes in on iconic Galápagos wildlife
2. New discovery brings customized tuberculosis therapies based on genotype closer to reality
3. Discovery of natural antibody brings a universal flu vaccine a step closer
4. Scientists a step closer to understanding natural antifreeze molecules
5. IOF calls for improved strategies to close the treatment gap and reduce future burden of fractures
6. Too close for comfort? Maybe not
7. Closer look at cell membrane shows cholesterol keeping order
8. Getting closer to a better biocontrol for garden pests
9. Study shows hunger hitting closer to home
10. Stem cell therapy for age-related macular degeneration -- a step closer to reality
11. U of M researchers close in on technology for making renewable petroleum
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Close up look at a microbial vaccination program
(Date:7/20/2015)...  Acuity Market Intelligence,s latest research "The Global ... and Privacy" forecasts that between 2014 and 2020 ... downloaded to smart mobile devices by 2.2 billion ... projected to generate more than $67.9 billion in ... period.    "Biometrics is at the ...
(Date:7/9/2015)... July 9, 2015  Synaptics Inc. (NASDAQ: SYNA ), ... that it will report financial results for the fourth ... 2015 after the close of market. The company will ... at 2:00 p.m. PT (5:00 p.m. ET), during which ... participate on the live call, analysts and investors should ...
(Date:7/9/2015)... JOSE, Calif. , July 9, 2015 ... the leading developer of human interface solutions, ... technology, the industry,s first fully hardware encapsulated ... Match-in-Sensor secure authentication technology is literally off ... storage and biometric matching within the fingerprint ...
Breaking Biology News(10 mins):Biometrics on Smart Mobile Devices to Redefine Digital Identity with 12.9 Billion Biometric App Downloads between 2014 and 2020 2Synaptics to Report Fourth Quarter, Fiscal Year 2015 Results on July 30 2Synaptics Announces World's First Match-in-Sensor Fingerprint Authentication Technology 2Synaptics Announces World's First Match-in-Sensor Fingerprint Authentication Technology 3
... humans: pubic lice, Pthirus pubis , and human head ... in BioMed Central,s open access Journal of Biology ... In the article, Robert Weiss from University ... pondering the question of why lice would separate into two ...
... In a fight against respiratory infections, the body typically ... productive cough. But new research suggests that the influenza virus ... lungs, interfering with the supply of oxygen to the rest ... to eliminate the virus, but this research suggests that it,s ...
... The genome of a marine bacterium living 2,500 meters ... life adapts in extreme thermal and chemical gradients, according ... PLoS Genetics , an open-access publication published by ... on the bacterium Nautilia profundicola , a microbe ...
Cached Biology News:Study: Fluid buildup in lungs is part of the damage done by the flu 2Study: Fluid buildup in lungs is part of the damage done by the flu 3Genetic adaptations key to microbe's survival in challenging environment 2
(Date:7/30/2015)... , July 30, 2015   Aratana ... pet therapeutics company focused on the licensing, development ... animals, today announced that its strategic partner VetStem ... dose confirmation study of AT-016, an adipose-derived allogeneic ... the treatment of osteoarthritis pain in dogs. ...
(Date:7/30/2015)... Denmark , July 30, 2015 ... biotechnology company that applies its innovative TransCon technology ... positive top-line results from a six-month Phase 2 ... once-weekly TransCon Growth Hormone in 53 treatment-naïve, pre-pubertal ... "We are extremely pleased with the top-line ...
(Date:7/30/2015)... ... 2015 , ... As part of its 2015 growth plan and as a follow up to ... business units, Whitehouse Laboratories is pleased to announce that it has begun construction on a ... Excellence and will be strictly dedicated to basic USP 51, USP 61, and USP 62 ...
(Date:7/29/2015)... 30, 2015 Sanofi, un ... ses résultats pour le premier semestre 2015. Le ... résultats. Visionner l,interview vidéo et lire ... Au sommaire de l,interview :  ... de croissance - Diabète ...
Breaking Biology Technology:Aratana Therapeutics Announces Positive Pilot Field Study for AT-016 2Aratana Therapeutics Announces Positive Pilot Field Study for AT-016 3Aratana Therapeutics Announces Positive Pilot Field Study for AT-016 4Aratana Therapeutics Announces Positive Pilot Field Study for AT-016 5Ascendis Pharma A/S Announces Positive Top-line Results from a Phase 2 Pediatric Study of Once-Weekly TransCon Growth Hormone for the Treatment of Growth Hormone Deficiency 2Ascendis Pharma A/S Announces Positive Top-line Results from a Phase 2 Pediatric Study of Once-Weekly TransCon Growth Hormone for the Treatment of Growth Hormone Deficiency 3Ascendis Pharma A/S Announces Positive Top-line Results from a Phase 2 Pediatric Study of Once-Weekly TransCon Growth Hormone for the Treatment of Growth Hormone Deficiency 4Ascendis Pharma A/S Announces Positive Top-line Results from a Phase 2 Pediatric Study of Once-Weekly TransCon Growth Hormone for the Treatment of Growth Hormone Deficiency 5Ascendis Pharma A/S Announces Positive Top-line Results from a Phase 2 Pediatric Study of Once-Weekly TransCon Growth Hormone for the Treatment of Growth Hormone Deficiency 6Ascendis Pharma A/S Announces Positive Top-line Results from a Phase 2 Pediatric Study of Once-Weekly TransCon Growth Hormone for the Treatment of Growth Hormone Deficiency 7Whitehouse Labs Formally Announces Plans to Open a Microbiological Laboratory 2
... adept at climbing through difficult terrain using an intricate adhesive ... how they switch on their unique system of traction. ... South Carolina have discovered that the geckos, amazing grip is ... adhesive research will be published Wed., Aug. 5, at 00:001 ...
... , , SOUTH SAN ... PARD ), a biopharmaceutical company focused on oncology, today reported financial ... a corporate update. , , "During the ... 2 picoplatin data from our colorectal and prostate cancer programs. ...
... NEW YORK, Aug. 4 Keryx Biopharmaceuticals, Inc. (Nasdaq: KERX ... 8:30 a.m. EDT to discuss the second quarter 2009 financial results and ... Officer of the Company, will host the call. Keryx will announce ... issued prior to the call. , , In order ...
Cached Biology Technology:New angle on gecko research 2Poniard Pharmaceuticals Reports Second Quarter 2009 Financial Results and Provides a Corporate Update 2Poniard Pharmaceuticals Reports Second Quarter 2009 Financial Results and Provides a Corporate Update 3Poniard Pharmaceuticals Reports Second Quarter 2009 Financial Results and Provides a Corporate Update 4Poniard Pharmaceuticals Reports Second Quarter 2009 Financial Results and Provides a Corporate Update 5Poniard Pharmaceuticals Reports Second Quarter 2009 Financial Results and Provides a Corporate Update 6Poniard Pharmaceuticals Reports Second Quarter 2009 Financial Results and Provides a Corporate Update 7Poniard Pharmaceuticals Reports Second Quarter 2009 Financial Results and Provides a Corporate Update 8Keryx Biopharmaceuticals, Inc. to Hold Conference Call on Second Quarter 2009 Financial Results on Thursday, August 6, 2009 at 8:30am EDT 2
... Kit, 500 reactions. Prepare circular DNA ... h.Generate microgram quantities of template DNA ... amplified DNA directly for cycle sequencing ... M13 liquid cultures, colonies, plaques, or ...
...
Request Info...
Spaced cover glasses to promote effective hybridization...
Biology Products: