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Clinical trials for Alzheimer's disease preventative drug to begin early 2013
Date:5/22/2012

(Santa Barbara, Calif.) After an announcement by federal officials approving clinical trials for the drug Crenezumab, researchers searching for a way to treat Alzheimer's Disease are gearing up for a rare study that will allow them to test a therapy for a genetically predestined disease before its onset.

"This is really incredible," said UC Santa Barbara neuroscientist Ken Kosik, who is the Harriman Professor of Neuroscience Research in the Department of Molecular, Cellular & Developmental Biology, and co-director of UCSB's Neuroscience Research Institute. He, along with several other Alzheimer's experts in the United States and Colombia, will be conducting the five-year, $100 million study, starting early next year.

The scientists will be drawing their study participants from a large family in Medelln, Colombia. It's a family of about 3,000, with the unfortunate distinction of coming down with the disease early in life onset begins at around 49 years of age. Unlike the kind of Alzheimer's that strikes late in life, this particular form has been traced to a specific genetic mutation.

"Almost everybody, if they have the mutation, gets the disease like clockwork," said Kosik, who first met with members of the family in the early 1990's, just after starting his work with Alzheimer's as an assistant professor at Harvard University. His interests led him to Bogot, where he met Francisco Lopera, the Colombian neurologist who told him of the family, and who is another lead researcher on the study.

At the time, there was the interest in starting treatment and research, but the country was in upheaval, caught between political insurgents, drug cartels, and internal armed conflicts. Pharmaceutical companies were reluctant to invest or participate in any trials.

Two decades later, not only has turmoil in the country decreased, but the thinking toward treatment of Alzheimer's Disease has shifted from cure to prevention, pavin
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Contact: Sonia Fernandez
sonia.fernandez@ia.ucsb.edu
805-893-4765
University of California - Santa Barbara
Source:Eurekalert  

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