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Clinical trial for diabetic macular edema enrolling patients
Date:3/26/2010

y information and participation, please visit www.READ3.net or JDRF's Clinical Trials Connection at www.trials.jdrf.org.

Without treatment, diabetic macular edema can cause vision impairment, blurriness, or blindness. Therapies to free people from the devastating health burden of complications that can accompany diabetes, including diseases of the eye, nerves, and kidneys, are an important focus of JDRF research; in the last fiscal year, the foundation invested more than $22 million in research involving Complications Therapies.

About Ranibizumab and the READ Studies

The READ-3 Trial is the third READ study to test the effectiveness of ranibizumab as a treatment of diabetic eye disease.

Ranibizumab is an antibody designed to block a protein called vascular endothelial growth factor (VEGF), which is produced in excessive amounts in people with diabetes. VEGF causes leakage in the small blood vessels of the eye that can lead to vision loss and, eventually, blindness. In the READ-1 study, Dr. Quan Dong Nguyen, Dr. Peter Campochiaro, and colleagues at the Wilmer Eye Institute of Johns Hopkins University (under the JDRF collaboration) treated 10 patients who suffered from chronic diabetic macular edema. The trial participants received injections of the drug, with follow-up injections at one, two, four, and six months. The injections were well-tolerated and the results showed that ranibizumab significantly reduced macular swelling and improved vision.

In the READ-2 Study (a multi-center national trial also supported by JDRF) designed by Dr. Nguyen, Dr. Campochiaro, and Dr. Dia
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Contact: Joana Casas
mcasas@jdrf.org
212-479-7560
Juvenile Diabetes Research Foundation International
Source:Eurekalert

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