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Clinical Tests Demonstrate Long-Term Effectiveness of Oral Glutathione Supplements - Kyowa Study

NEW YORK, May 7, 2013 /PRNewswire-iReach/ -- Glutathione is the body's master antioxidant involved in protecting cells and tissues from oxidants and a large variety of other toxins and insults. Debate over whether orally administered glutathione could be effective at enhancing glutathione levels in cells and tissues has simmered for years. Now, a Penn State College of Medicine study shows oral supplementation is effective in increasing the body's stores of this vital nutrient.


The study of 54 healthy adults revealed that glutathione (GSH) levels of those taking 1000mg of Setria® Glutathione a day for six months increased 30%-35% in many compartments including red blood cells, lymphocytes and plasma, and of those taking 250mg of Setria® Glutathione increased in whole blood. And as glutathione stores increased in the high-dose group, so did the function of natural killer (NK) cells, a marker for increased immune defense, said John P. Richie, Jr. , Ph.D., professor of Public Health Sciences and Pharmacology at Penn State College of Medicine.

"A battery of immune function markers was examined after three months of glutathione supplementation and NK cytotoxicity was enhanced more than two-fold for participants taking 1000mg daily doses," Dr. Richie said. "We believe GSH supplementation may represent an effective intervention strategy for disease prevention and may enhance immune function."

There is a school of thought that contends that glutathione is broken down in the stomach and intestine and effective increases of GSH must come via intravenous administration. However, previous animal studies showed that orally administered glutathione is bioavailable and will enhance tissue GSH levels, Dr. Richie said.

"Our research showed that in most cases increases were dose and time dependent, and levels returned to baseline after a one-month washout," he said. "By taking daily GSH supplements, we believe efficacious levels will persist, and that oral intake is an effective means of chronically enhancing the body's stores."

Dr. Richie presented the study findings – "Enhanced Glutathione Levels in Blood and Buccal Cells by Oral Glutathione Supplementation" – at the Experimental Biology 2013 conference in Boston on April 22. The study was a joint effort of the Pennsylvania Department of Public Health Sciences, the Penn State Hershey Cancer Institute, and the Penn State College of Medicine.

About John P. Richie , Ph.D.

Dr. Richie is professor, Public Health Sciences and Pharmacology, at Penn State College of Medicine, State College, Penn. He has researched has researched glutathione for more than 30 years, including its role in protecting against oxidative damage during aging and the development of cancer at numerous sites in the body. Dr. Richie's research focuses on the factors that regulate glutathione, oxidative stress and cancer risk in individuals and in various populations.

About Setria

Setria® Glutathione, manufactured by Kyowa Hakko USA, is a clinically studied, absorbable form of glutathione that can help replenish the body's reserves that may be depleted as a result of poor lifestyle choices, stress, or natural aging. Called the "master antioxidant," benefits of glutathione include protecting cells in the body from the damaging effects of oxidative stress and toxins. Setria Glutathione is manufactured through a patented fermentation and patent pending for increasing NK natural killer (NK) cells, is pure, vegetarian and allergen-free. For more information about Setria GSH, please visit:

About Kyowa Hakko USA

Kyowa Hakko USA is the North American sales office for Kyowa Hakko Bio Co. Ltd., an international health ingredients manufacturer and world leader in the development, manufacturing and marketing of pharmaceuticals, nutraceuticals and food products. Kyowa is the maker of branded ingredients including Cognizin® Citicoline, Lumistor® L-Hydroxyproline, Pantesin® Pantethine, Setria® Glutathione, as well as Sustamine™ L-Alanyl-L-Glutamine. For more information, visit

Media Contact:

Dave Clifton , Setria® Glutathione, 385-222-7035,

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