Navigation Links
Clingy platelets suggest potential treatment strategy for rheumatoid arthritis
Date:8/29/2013

Bethesda, MDNo one likes clingy people, but "clingy" blood platelets may offer hope for millions of people with rheumatoid arthritis. According to new research findings published in The Journal of Leukocyte Biology, a sub population of immune cells (lymphocytes) known to play a significant role in rheumatoid arthritis has platelets attached to their surface. Those attached platelets reduced the ability of the immune cells to cause disease by reducing their activity levels and ability to spread. This opens the door to new investigations into treatments that ultimately bind platelets to lymphocytes. In addition, understanding this process may serve as a tool for better being able to predict the severity of the disease.

"We hope with this knowledge to contribute to the reduction in the chronicity of inflammatory diseases, one of the main aspects that compromise the quality of life of the patients," said Silvia Vidal, Ph.D., a researcher involved in the work from the Department of Immunology at the Institut Recerca of the Hospital Santa Creu I Sant Pau in Barcelona, Spain.

To make this discovery, scientists found specific platelet markers on the surface of lymphocytes from peripheral blood of healthy donors by flow cytometry. Visual confirmation that these markers belonged to platelets attached to lymphocytes was achieved by confocal microscopy. In cell cultures, those lymphocytes with bound platelets were less sensitive to activation and proliferation, and they produced less inflammatory mediators. Researchers analyzed the frequency of these platelet-bound lymphocytes in the peripheral blood of 20 rheumatoid arthritis patients. Associations were established between clinical parameters and activity disease scores and the frequency of platelet-bound lymphocytes.

"This report expands our understanding of how the mechanisms of inflammation operate and reveal new potential ways we can bring it under control," said John Wherry, Ph.D., Deputy Editor of the Journal of Leukocyte Biology. "Defining how platelets regulate other immune cells by binding to their surface and influencing their role in inflammation, is an important step toward new platelet-based treatments to control damaging inflammatory diseases caused by many immune cells."


'/>"/>

Contact: Cody Mooneyhan
cmooneyhan@faseb.org
301-634-7104
Federation of American Societies for Experimental Biology
Source:Eurekalert

Related biology news :

1. Artificial platelets could treat injured soldiers on the battlefield
2. Nanoparticles added to platelets double internal injury survival rate
3. UC Santa Barbara researchers develop synthetic platelets
4. HB-EGF protects intestines from a variety of injuries, pair of studies suggests
5. Study suggests way to fight therapy resistant leukemia by blocking DNA repair
6. U of T-led study cracks universal RNA code, suggests a new cause for autism
7. Metastatic pancreatic, primary breast cancer have common growth mechanisms, study suggests
8. Evidence suggests Antarctic crabs could be native
9. Low levels of toxic proteins linked to brain diseases, study suggests
10. Survey of physicians suggests tablets more useful than smartphones
11. Recovery of Hawaiian green sea turtles still short of historic levels, Stanford-led study suggests
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/6/2017)... , March 6, 2017 ... sales technology, today announced Predictive Sales Coach TM ... infusing actionable sales intelligence into Salesforce. This unique ... enable their sales organizations with deep knowledge of ... allow for intelligent engagement. Predictive Sales Coach extends ...
(Date:3/2/2017)... -- Who risk to be deprived of its imprint ... https://www.reportbuyer.com/product/4313699/ WILL APPLE AND SAMSUNG CONFRONT ... sensors using capacitive technology represent a fast growing market, ... an increase of 360% of the number of fingerprint ... sensor market between 2014 and 2017 (source : N+1 ...
(Date:2/28/2017)... LOS ANGELES , Feb. 28, 2017   ... identity verification software globally, announces significant enhancements to new ... in May 2016. New products include mobile and desktop ... and DocX TM - a real time manual ... Acuant,s core idScan® technology provides the fastest and most ...
Breaking Biology News(10 mins):
(Date:3/27/2017)... -- Infectex Ltd., a Russian portfolio company of Maxwell Biotech Venture Fund ... to the standard drug therapy regimen in patients with multidrug-resistant pulmonary tuberculosis (MDR-TB). SQ109 ... USA ) and the US National Institutes of Health. ... ... ...
(Date:3/27/2017)... March 27, 2017  Perthera,s Chief Bioinformatics Officer and ... Subha Madhavan , Ph.D., will be speaking at the ... On Monday, March 27, 2017, she will be speaking ... Usable for Research and Care" (from 10:30 a.m. – ... she will be a participant in the "Making Precision ...
(Date:3/27/2017)... ... 2017 , ... PMG Research is pleased to announce its participation ... Conference Forum in Boston on April 3-4, 2017. The CTC conference focuses on how ... and bring them closer to the patient. Clinical Trial Collaborations also will present an ...
(Date:3/27/2017)... , March 27, 2017  Trovagene, Inc. (NASDAQ: ... its Chief Executive Officer, Bill Welch , will ... 4, 2017 at 9:00 AM EDT at the Essex ...  Bill Welch, and Chief Scientific Officer, Mark Erlander ... investors during the conference.   The presentation will ...
Breaking Biology Technology: