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Cleveland researchers collaborate to launch Phase 1 clinical trial for new MS treatment
Date:8/23/2011

utious approach, carefully monitoring for any unexpected side effects, as we look to see if MSC have the abilities that we anticipate."

MSCs have a wide range of effects that decrease the activity of immune cells while encouraging tissue repair, both of which may be beneficial in MS. In addition, in numerous laboratory studies, MSCs were able to migrate from the blood into areas of inflammation or injury in the nervous system and reduce damage probably by creating a tissue environment that encourages the body's intrinsic repair processes.

Study participants will be monitored very closely for six months after they receive the MSC transplantation, including physical exams, blood work, and other testing to determine whether the procedure is safe and well-tolerated. The research team will also monitor their disease status through quantitative neurologic exam, vision testing, advanced MRI, and optical coherence tomography of the retina prior to and for six months after MSC administration to evaluate whether the procedure impacts the activity or severity of each participant's MS. Finally, in collaboration with investigators at the Montreal Neurological Institute, the immunologic effects of MSCs will be comprehensively assessed, both in culture and in the patients.

Cleveland is one of only a handful of locations in the country where a research endeavor like this could be conducted because it is home to a "dream team" of clinical and research experts with strong collegial relationships; located less than two miles from each other:

They include:

  • Cleveland Clinic's Mellen Center for Multiple Sclerosis Treatment and Research, part of the Neurological Institute;

  • University Hospitals (UH) Seidman Cancer Center Coleman Clinical Research Suite;

  • Cellular Therapy Laboratory (CTL) based in the Case Western Reserve University School of Medicine National Center for Regenerative Medicine (NCRM), a m
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Contact: George Stamatis
george.stamatis@uhhospitals.org
216-844-3667
University Hospitals Case Medical Center
Source:Eurekalert

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