Navigation Links
Cleveland Clinic study discovers new targets for treating inflammatory, autoimmune diseases

Friday, October 7, 2011, Cleveland: Researchers have discovered a cellular pathway that promotes inflammation in diseases like asthma, rheumatoid arthritis, psoriasis, inflammatory bowel disease, and multiple sclerosis. Understanding the details of this pathway may provide opportunities for tailored treatments of inflammatory and autoimmune diseases.

Discovery of this pathway was the work of an active collaboration between Xiaoxia Li, Ph.D., and Thomas Hamilton, Ph.D., Department Chair, both of the Department of Immunology at Lerner Research Institute of Cleveland Clinic.

Their publications in Nature Immunology, selected for a News and Views article in the same issue, portray how a protein molecule known as interleukin-17 (IL-17) spurs inflammation by recruiting specific white blood cells to sites of infection and injury, producing a strong, pathogenic response.

Being able to block this pathway may treat IL-17-induced inflammatory diseases. Molecular factors discovered by Li and Hamilton make this concept a potential strategy.

"We are excited by the possibilities that this new research opens up for developing improved therapeutics for these difficult diseases," Hamilton said.

"Being able to collaborate like this really expedites the science," Li added, "ultimately leading, we hope, to profound improvement for those suffering from these autoimmune and inflammatory conditions."


Contact: Dan Doron
Lerner Research Institute

Page: 1

Related biology news :

1. Ohio Third Frontier awards $2.5 million for imaging research in Cleveland
2. Cleveland researchers collaborate to launch Phase 1 clinical trial for new MS treatment
3. Radiation from Japan detected in Cleveland
4. Cleveland Clinic researchers honored for contributions to science and technology
5. Draft sequence of Neandertal genome wins the 2010 AAAS Newcomb Cleveland Prize, supported by Affymetrix
6. Cleveland Museum of Natural History scientist announces new horned dinosaur
7. Cleveland Clinic, CWRU dental researcher finds switch that turns on the spread of cancer
8. AMIA advises FDA on clinical decision support
9. Reports highlight the evolving role of clinical microbiology laboratories
10. New research validates clinical importance of leukemia stem cells
11. Clinical study shows young brains lack the wisdom of their elders
Post Your Comments:
(Date:10/26/2015)... India , October 26, 2015 ... --> adds ... 2015 to 2021 as well as ... 2015-2019 research reports to its collection ... . --> ...
(Date:10/23/2015)... Oct. 23, 2015 Research and Markets ( ... "Global Voice Recognition Biometrics Market 2015-2019" report to ... --> The global voice recognition biometrics market to ... --> --> The ... prepared based on an in-depth market analysis with inputs ...
(Date:10/22/2015)... 2015  Synaptics (NASDAQ: SYNA ), a leading developer of ... ended September 30, 2015. --> ... grew 66 percent over the comparable quarter last year to $470.0 ... $23.8 million, or $0.62 per diluted share. ... quarter of fiscal 2016 grew 39 percent over the prior year ...
Breaking Biology News(10 mins):
(Date:11/25/2015)... Orexigen® Therapeutics, Inc. (Nasdaq: OREX ) ... chat discussion at the Piper Jaffray 27th Annual Healthcare ... discussion is scheduled for Wednesday, December 2, at 8:00 ... replay will be available for 14 days after the ... NormartVP, Corporate Communications and Business Development , BrewLife(858) 875-8629 ...
(Date:11/24/2015)... -- Cepheid (NASDAQ: CPHD ) today announced that ... and invited investors to participate via webcast. ... 1, 2015 at 11.00 a.m. Eastern Time --> ... 1, 2015 at 11.00 a.m. Eastern Time --> ... NY      Tuesday, December 1, 2015 at 11.00 ...
(Date:11/24/2015)... /PRNewswire/ - Aeterna Zentaris Inc. (NASDAQ:  AEZS) (TSX: AEZ) (the ... the Toronto Stock Exchange, confirms that as of the ... developments that would cause the recent movements in the ... --> About Aeterna Zentaris Inc. ... Aeterna Zentaris is a specialty biopharmaceutical company engaged in ...
(Date:11/24/2015)... 2015 SHPG ) announced today that ... Jaffray 27 th Annual Healthcare Conference in New ... 8:30 a.m. EST (1:30 p.m. GMT). --> SHPG ) ... participate in the Piper Jaffray 27 th Annual Healthcare Conference ... December 1, 2015, at 8:30 a.m. EST (1:30 p.m. GMT). ...
Breaking Biology Technology: