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Cleveland Clinic researchers receive $5 million grant to discover novel pathways to heart disease
Date:7/12/2012

organisms in their digestive tracts metabolize a specific lipid phosphatidylcholine (also called lecithin). For that discovery, Dr. Hazen and his research team were honored with an inaugural Top 10 Clinical Research Achievement Award from an organization comprised of the nation's most prestigious and acclaimed academic medical centers and other groups.

With the NHLBI grant, Dr. Hazen and his colleagues will extend their research by further analyzing the thousands of metabolites in blood, including many that are formed by gut flora, in order to discover pathways linked to causing heart attacks, strokes, and heart failure. They also propose to manipulate the bacteria in humans, testing whether specific probiotics can play a role in treatment of cardiovascular disease. The research can thus ultimately lead to new treatments, including diets and drugs, for cardiovascular disease as well as improved diagnostics and prevention.

Cleveland Clinic's grant (NHLBI grant number: 1P20HL113452-01) is part of a series awarded by the National Institutes of Health to study the abnormal metabolism of cardiovascular and lung diseases. In addition to Drs. Hazen and Tang, the research team includes co-investigator Zeneng Wang, Ph.D., of Cleveland Clinic; Oliver Fiehn, M.D., of the University of California, Davis; and David Lefer, Ph.D., of Emory University.


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Contact: Wyatt DuBois
duboisw@ccf.org
216-445-9946
Cleveland Clinic
Source:Eurekalert

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