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Cleveland Clinic researchers receive $5 million grant to discover novel pathways to heart disease
Date:7/12/2012

Thursday, July 12, 2012, Cleveland: The National Heart, Lung, and Blood Institute (NHLBI) has awarded a $4.78 million grant to researchers at Cleveland Clinic's Lerner Research Institute to use metabolomics a new approach that focuses on the small-molecule byproducts of metabolism for discovery of novel pathways linked to the development of cardiovascular diseases.

"Despite the identification of numerous genetic and clinical risk factors for cardiovascular disease, we can still only explain in a small fraction of patients why that individual develops the disease; this means many novel pathways contributing to the disease still remain unexplored," said Stanley Hazen, M.D., Ph.D., vice chair of the Lerner Research Institute and section head of Preventive Cardiology & Rehabilitation in the Miller Family Heart and Vascular Institute.

Hazen is co-principal investigator on the study with W.H. Wilson Tang, M.D., director of the Cardiomyopathy Program at Cleveland Clinic, and research director of the Section of Heart Failure and Cardiac Transplantation Medicine in the Miller Family Heart and Vascular Institute.

"By using metabolomics approaches, our goal is to better understand at the molecular-level the mechanisms that cause cardiovascular diseases," said Dr. Tang. "Metabolomics is a powerful discovery platform, and can help lead to improved diagnostics and better treatments to prevent development and progression of cardiovascular disease."

Dr. Hazen and his colleagues' prior research in this area has been successful in discovering new and unexpected pathways involved in heart disease. Last year they identified a dietary nutrient found in animal products that is metabolized by gut flora and linked to atherosclerosis, or the hardening or clogging of the arteries. In a study published in Nature, they found that people are not predisposed to cardiovascular disease solely on their genetic make-up, but also based on how the micro-
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Contact: Wyatt DuBois
duboisw@ccf.org
216-445-9946
Cleveland Clinic
Source:Eurekalert

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