Navigation Links
Cleveland Clinic researchers receive $5 million grant to discover novel pathways to heart disease
Date:7/12/2012

Thursday, July 12, 2012, Cleveland: The National Heart, Lung, and Blood Institute (NHLBI) has awarded a $4.78 million grant to researchers at Cleveland Clinic's Lerner Research Institute to use metabolomics a new approach that focuses on the small-molecule byproducts of metabolism for discovery of novel pathways linked to the development of cardiovascular diseases.

"Despite the identification of numerous genetic and clinical risk factors for cardiovascular disease, we can still only explain in a small fraction of patients why that individual develops the disease; this means many novel pathways contributing to the disease still remain unexplored," said Stanley Hazen, M.D., Ph.D., vice chair of the Lerner Research Institute and section head of Preventive Cardiology & Rehabilitation in the Miller Family Heart and Vascular Institute.

Hazen is co-principal investigator on the study with W.H. Wilson Tang, M.D., director of the Cardiomyopathy Program at Cleveland Clinic, and research director of the Section of Heart Failure and Cardiac Transplantation Medicine in the Miller Family Heart and Vascular Institute.

"By using metabolomics approaches, our goal is to better understand at the molecular-level the mechanisms that cause cardiovascular diseases," said Dr. Tang. "Metabolomics is a powerful discovery platform, and can help lead to improved diagnostics and better treatments to prevent development and progression of cardiovascular disease."

Dr. Hazen and his colleagues' prior research in this area has been successful in discovering new and unexpected pathways involved in heart disease. Last year they identified a dietary nutrient found in animal products that is metabolized by gut flora and linked to atherosclerosis, or the hardening or clogging of the arteries. In a study published in Nature, they found that people are not predisposed to cardiovascular disease solely on their genetic make-up, but also based on how the micro-organisms in their digestive tracts metabolize a specific lipid phosphatidylcholine (also called lecithin). For that discovery, Dr. Hazen and his research team were honored with an inaugural Top 10 Clinical Research Achievement Award from an organization comprised of the nation's most prestigious and acclaimed academic medical centers and other groups.

With the NHLBI grant, Dr. Hazen and his colleagues will extend their research by further analyzing the thousands of metabolites in blood, including many that are formed by gut flora, in order to discover pathways linked to causing heart attacks, strokes, and heart failure. They also propose to manipulate the bacteria in humans, testing whether specific probiotics can play a role in treatment of cardiovascular disease. The research can thus ultimately lead to new treatments, including diets and drugs, for cardiovascular disease as well as improved diagnostics and prevention.

Cleveland Clinic's grant (NHLBI grant number: 1P20HL113452-01) is part of a series awarded by the National Institutes of Health to study the abnormal metabolism of cardiovascular and lung diseases. In addition to Drs. Hazen and Tang, the research team includes co-investigator Zeneng Wang, Ph.D., of Cleveland Clinic; Oliver Fiehn, M.D., of the University of California, Davis; and David Lefer, Ph.D., of Emory University.


'/>"/>

Contact: Wyatt DuBois
duboisw@ccf.org
216-445-9946
Cleveland Clinic
Source:Eurekalert

Related biology news :

1. Collaborative preclinical efficacy studies suggest a new target for drug addiction treatment
2. Ottawa researchers to lead world-first clinical trial of stem cell therapy for septic shock
3. New clinical trial explores novel noninvasive colon cancer screening test
4. Genzyme/ACMG Foundation Genetics Training Award in Clinical Biochemical Genetics announced
5. FirstMark Exhibiting at the Inaugural Atlanta Clinical Cardiology Update
6. MedNet Solutions to Demonstrate Its Innovative Suite of eClinical Solutions at the 2012 Bio-IT World Conference & Expo
7. Clinical trial launches to see whether vitamin D helps treat multiple sclerosis
8. AAO-HNS releases updated Clinical Indicators
9. Sequencing works in clinical setting to help -- finally -- get a diagnosis
10. VolitionRX Raises Over $1 Million To Begin Clinical Trials of Blood Based Diagnostic Tests
11. Clinical trials for Alzheimers disease preventative drug to begin early 2013
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/19/2017)... April 19, 2017 The global ... landscape is marked by the presence of several large ... held by five major players - 3M Cogent, NEC ... accounted for nearly 61% of the global military biometric ... in the global military biometrics market boast global presence, ...
(Date:4/11/2017)... 11, 2017 Crossmatch®, a globally-recognized leader ... today announced that it has been awarded a ... Activity (IARPA) to develop next-generation Presentation Attack Detection ... "Innovation has been a driving force within Crossmatch ... allow us to innovate and develop new technologies ...
(Date:4/5/2017)... 5, 2017  The Allen Institute for Cell Science ... a one-of-a-kind portal and dynamic digital window into the ... the first application of deep learning to create predictive ... lines and a growing suite of powerful tools. The ... and future publicly available resources created and shared by ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... ... October 11, 2017 , ... The CRISPR-Cas9 ... overexpression experiments and avoiding the use of exogenous expression plasmids. The simplicity of ... performing systematic gain-of-function studies. , This complement to loss-of-function studies, such as ...
(Date:10/11/2017)... ... October 11, 2017 , ... Proscia Inc ... hosting a Webinar titled, “Pathology is going digital. Is your lab ready?” with ... adoption best practices and how Proscia improves lab economics and realizes an increase ...
(Date:10/11/2017)... ... October 11, 2017 , ... Disappearing forests and increased emissions are ... 5.5 million people each year. Especially those living in larger cities are affected by ... in one of the most pollution-affected countries globally - decided to take action. , ...
(Date:10/10/2017)... , ... October 10, 2017 , ... San Diego-based team ... its corporate rebranding initiative announced today. The bold new look is part of ... the company moves into a significant growth period. , It will also expand its ...
Breaking Biology Technology: