Navigation Links
Cleveland Clinic researchers discover neuroprotective role of immune cell
Date:7/22/2014

July 22, 2014, Cleveland: A type of immune cell widely believed to exacerbate chronic adult brain diseases, such as Alzheimer's disease and multiple sclerosis (MS), can actually protect the brain from traumatic brain injury (TBI) and may slow the progression of neurodegenerative diseases, according to Cleveland Clinic research published today in the online journal Nature Communications.

The research team, led by Bruce Trapp, PhD, Chair of the Department of Neurosciences at Cleveland Clinic's Lerner Research Institute, found that microglia can help synchronize brain firing, which protects the brain from TBI and may help alleviate chronic neurological diseases. They provided the most detailed study and visual evidence of the mechanisms involved in that protection.

"Our findings suggest the innate immune system helps protect the brain after injury or during chronic disease, and this role should be further studied," Dr. Trapp said. "We could potentially harness the protective role of microglia to improve prognosis for patients with TBI and delay the progression of Alzheimer's disease, MS, and stroke. The methods we developed will help us further understand mechanisms of neuroprotection."

Microglias are primary responders to the brain after injury or during illness. While researchers have long believed that activated microglia cause harmful inflammation that destroys healthy brain cells, some speculate a more protective role. Dr. Trapp's team used an advanced technique called 3D electron microscopy to visualize the activation of microglia and subsequent events in animal models.

They found that when chemically activated, microglia migrate to inhibitory synapses, connections between brain cells that slow the firing of impulses. They dislodge the synapse (called "synaptic stripping"), thereby increasing neuronal firing and leading to a cascade of events that enhance survival of brain cells.

Trapp is internationall
'/>"/>

Contact: Laura Ambro
ambrol@ccf.org
216-636-5876
Cleveland Clinic
Source:Eurekalert

Page: 1 2

Related biology news :

1. Cleveland Clinic researchers receive $5 million grant to discover novel pathways to heart disease
2. Cleveland Clinic develops clinical screening program for no.1 genetic cause of colon cancer
3. Cleveland Clinic research shows anemia drug does not improve health of anemic heart failure patients
4. Cleveland Clinic researchers discover new link between heart disease and red meat
5. Cleveland Clinic research shows gut bacteria byproduct predicts heart attack and stroke
6. Cleveland Clinics 2013 Obesity Summit explores causes, prevention and treatment of obesity
7. 2 Cleveland Clinic researchers honored for contribution to science
8. Cleveland Clinic identifies mechanism in Alzheimers-related memory loss
9. Cleveland Clinic researchers discover process that turns good cholesterol bad
10. Collaborative preclinical efficacy studies suggest a new target for drug addiction treatment
11. Ottawa researchers to lead world-first clinical trial of stem cell therapy for septic shock
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/31/2015)... Chine, 31 juillet 2015 La 10e ... ) sera organisée par le BGI du 22 ... en Chine. La conférence ... inauguration en 2006, l,ICG est devenue l,une des ... domaine des « omiques » et c,est aussi la plus ...
(Date:7/31/2015)... China , 31. Juli 2015 Die 10. ... wird von BGI veranstaltet und findet vom 22. ... China , statt. Die ... Seit ihrem Start 2006 ist die ICG weltweit ... „omik" geworden. Sie ist eines der dynamischsten, enthusiastischsten ...
(Date:7/31/2015)... , July 31, 2015 The 10 th ... be held by BGI from October 22-25, 2015, in ... The conference is celebrating its 10 th anniversary this ... of the world,s most influential annual meetings in the ,omics, ... enjoyable scientific gatherings. ICG-10 focuses on recent ...
Breaking Biology News(10 mins):La 10e International Conference on Genomics (ICG-10) doit s'ouvrir en octobre 2La 10e International Conference on Genomics (ICG-10) doit s'ouvrir en octobre 3Die 10. internationale Konferenz zu Genomik (ICG-10) beginnt im Oktober 2Die 10. internationale Konferenz zu Genomik (ICG-10) beginnt im Oktober 3The 10th International Conference on Genomics (ICG-10) to Open in October 2
... is chameleon-like in its replication. As HIV copies itself ... evade even the best cocktail of current therapies. Understanding ... key to developing better tests and treatments for patients. ... and Nature Structural & Molecular Biology, MU microbiologist and ...
... of Illinois researchers have found a key to keeping stem ... In a paper published in the journal PLoS ... cells (mESCs) on a soft gel rather than on a ... a ground state with the ability to become any type ...
... an automated screening technique developed by pharmaceutical companies to ... San Diego and three other research institutions has discovered ... on the biological clock. Dubbed by the scientists ... biological clock, the new compound and the application of ...
Cached Biology News:New discoveries make it harder for HIV to hide from drugs 2Soft substrate promotes pluripotent stem cell culture 2Soft substrate promotes pluripotent stem cell culture 3Researchers discover compound with potent effects on biological clock 2Researchers discover compound with potent effects on biological clock 3
(Date:8/28/2015)... , August 28, 2015 According ... (Media, Sera, Cryogenic Storage Systems, Thawing Equipment, Alarms), by ... Medicine, Clinical Trials), End User - Global Forecast to ... expected to reach USD 3,731.03 Million by 2020 from ... of 11.65% between 2015 and 2020. ...
(Date:8/28/2015)... /PRNewswire/ - RepliCel Life Sciences Inc. (OTCQB: REPCF) ... on the development of autologous cell therapies, today ... 30, 2015, corporate highlights, and near-term milestones.  The ... at www.sedar.com ,  www.edgar.com and ... expects to launch its RCS-01 treatment for aging ...
(Date:8/27/2015)... ... August 27, 2015 , ... The Kansas City Animal ... and animal health companies to hear from animal health companies with the newest ... received licensing agreements or distribution contracts. This meeting is one of the ...
(Date:8/27/2015)... 2015 /PRNewswire/ - Portage Biotech Inc. ("Portage") (OTC ... Pharmaceutical Holding Company Limited (Biohaven), announced today that ... of BHV-0223, a glutamate modulating agent. Biohaven filed ... recently obtained clearance from the U.S. Food and ... Portage holds 54% equity interest in Biohaven, a ...
Breaking Biology Technology:Biopreservation Market Worth 3,731.03 Million USD by 2020 2Biopreservation Market Worth 3,731.03 Million USD by 2020 3Biopreservation Market Worth 3,731.03 Million USD by 2020 4Biopreservation Market Worth 3,731.03 Million USD by 2020 5RepliCel Reports Second Quarter 2015 Financial Results 2RepliCel Reports Second Quarter 2015 Financial Results 3RepliCel Reports Second Quarter 2015 Financial Results 4RepliCel Reports Second Quarter 2015 Financial Results 5VetStem Biopharma, Inc. Among Seventeen Companies Selected to Present at the KC Animal Health Investment Forum on September 1st 2015 2VetStem Biopharma, Inc. Among Seventeen Companies Selected to Present at the KC Animal Health Investment Forum on September 1st 2015 3Portage's Biohaven doses first human subject in Phase 1 trial with lead drug candidate BHV-0223 2Portage's Biohaven doses first human subject in Phase 1 trial with lead drug candidate BHV-0223 3Portage's Biohaven doses first human subject in Phase 1 trial with lead drug candidate BHV-0223 4
... Human plasma and serum represents an important biological material for , ... in protein concentration , remains a major ... the very low concentration of biomarker proteins in the presence of high ... strategy is to remove 99% , of ...
... DNeasy Blood & Tissue ... and 96-well-plate,formats. Most samples can be directly lysed with proteinase K, ... for specific sample types provide reproducible purification of high-quality DNA for ... , ...
... Diseases Using the ASCENTATM System , ... Indications , Introduction ... , ESR1 (Estrogen Specific Receptor ... bind to steroid hormones in the cytoplasm, causing their translocation to the ...
Cached Biology Technology:Protein Depletion for Plasma and Serum Proteomic Analysis 2Protein Depletion for Plasma and Serum Proteomic Analysis 3Protein Depletion for Plasma and Serum Proteomic Analysis 4Protein Depletion for Plasma and Serum Proteomic Analysis 5Protein Depletion for Plasma and Serum Proteomic Analysis 6Protein Depletion for Plasma and Serum Proteomic Analysis 7Protein Depletion for Plasma and Serum Proteomic Analysis 8Protein Depletion for Plasma and Serum Proteomic Analysis 9Protein Depletion for Plasma and Serum Proteomic Analysis 10Protein Depletion for Plasma and Serum Proteomic Analysis 11Protein Depletion for Plasma and Serum Proteomic Analysis 12Protein Depletion for Plasma and Serum Proteomic Analysis 13Protein Depletion for Plasma and Serum Proteomic Analysis 14Protein Depletion for Plasma and Serum Proteomic Analysis 15Protein Depletion for Plasma and Serum Proteomic Analysis 16Protein Depletion for Plasma and Serum Proteomic Analysis 17Protein Depletion for Plasma and Serum Proteomic Analysis 18Protein Depletion for Plasma and Serum Proteomic Analysis 19Protein Depletion for Plasma and Serum Proteomic Analysis 20Protein Depletion for Plasma and Serum Proteomic Analysis 21Protein Depletion for Plasma and Serum Proteomic Analysis 22Protein Depletion for Plasma and Serum Proteomic Analysis 23Protein Depletion for Plasma and Serum Proteomic Analysis 24Protein Depletion for Plasma and Serum Proteomic Analysis 25Protein Depletion for Plasma and Serum Proteomic Analysis 26Protein Depletion for Plasma and Serum Proteomic Analysis 27Protein Depletion for Plasma and Serum Proteomic Analysis 28Protein Depletion for Plasma and Serum Proteomic Analysis 29Protein Depletion for Plasma and Serum Proteomic Analysis 30Protein Depletion for Plasma and Serum Proteomic Analysis 31Protein Depletion for Plasma and Serum Proteomic Analysis 32DNA purification from pig ears to bird blood using proven DNeasy Technology 2ESR1 Gene Expression in Oncology and Metabolic Diseases Using the ASCENTATM System , Target Validation and Identification of Novel Disease Indications 2ESR1 Gene Expression in Oncology and Metabolic Diseases Using the ASCENTATM System , Target Validation and Identification of Novel Disease Indications 3ESR1 Gene Expression in Oncology and Metabolic Diseases Using the ASCENTATM System , Target Validation and Identification of Novel Disease Indications 4
... ACS Reagent Grade C 19 H 9 ... 691.95 PRODUCT SPECIFICATIONS Form: Powder Clarity of ... pH 3.0 - Yellow pH 4.6 ... dye in agarose and acrylamide gel electrophoresis. ...
tracking dye in electrophoresis; free acid, C 19 H 10 BrO 5 S; MW: 669.96...
Denhardt's Solution is a mixture of blocking agents used in membrane-based hybridization protocols. The solution contains 1% Ficoll (type 400) 1% polyvinylpyrrolidone and 1% bovine serum albumin. Ste...
... CHEMICONs ELF 97 Cytological Labeling Kit provides ... the detection of cellular targets, including cell-surface ... Cytological Labeling Kit contains the patented ELF ... fluorescent yellow-green precipitate at the site of ...
Biology Products: