Navigation Links
Cleveland Clinic researchers discover neuroprotective role of immune cell
Date:7/22/2014

July 22, 2014, Cleveland: A type of immune cell widely believed to exacerbate chronic adult brain diseases, such as Alzheimer's disease and multiple sclerosis (MS), can actually protect the brain from traumatic brain injury (TBI) and may slow the progression of neurodegenerative diseases, according to Cleveland Clinic research published today in the online journal Nature Communications.

The research team, led by Bruce Trapp, PhD, Chair of the Department of Neurosciences at Cleveland Clinic's Lerner Research Institute, found that microglia can help synchronize brain firing, which protects the brain from TBI and may help alleviate chronic neurological diseases. They provided the most detailed study and visual evidence of the mechanisms involved in that protection.

"Our findings suggest the innate immune system helps protect the brain after injury or during chronic disease, and this role should be further studied," Dr. Trapp said. "We could potentially harness the protective role of microglia to improve prognosis for patients with TBI and delay the progression of Alzheimer's disease, MS, and stroke. The methods we developed will help us further understand mechanisms of neuroprotection."

Microglias are primary responders to the brain after injury or during illness. While researchers have long believed that activated microglia cause harmful inflammation that destroys healthy brain cells, some speculate a more protective role. Dr. Trapp's team used an advanced technique called 3D electron microscopy to visualize the activation of microglia and subsequent events in animal models.

They found that when chemically activated, microglia migrate to inhibitory synapses, connections between brain cells that slow the firing of impulses. They dislodge the synapse (called "synaptic stripping"), thereby increasing neuronal firing and leading to a cascade of events that enhance survival of brain cells.

Trapp is internationall
'/>"/>

Contact: Laura Ambro
ambrol@ccf.org
216-636-5876
Cleveland Clinic
Source:Eurekalert

Page: 1 2

Related biology news :

1. Cleveland Clinic researchers receive $5 million grant to discover novel pathways to heart disease
2. Cleveland Clinic develops clinical screening program for no.1 genetic cause of colon cancer
3. Cleveland Clinic research shows anemia drug does not improve health of anemic heart failure patients
4. Cleveland Clinic researchers discover new link between heart disease and red meat
5. Cleveland Clinic research shows gut bacteria byproduct predicts heart attack and stroke
6. Cleveland Clinics 2013 Obesity Summit explores causes, prevention and treatment of obesity
7. 2 Cleveland Clinic researchers honored for contribution to science
8. Cleveland Clinic identifies mechanism in Alzheimers-related memory loss
9. Cleveland Clinic researchers discover process that turns good cholesterol bad
10. Collaborative preclinical efficacy studies suggest a new target for drug addiction treatment
11. Ottawa researchers to lead world-first clinical trial of stem cell therapy for septic shock
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/18/2014)... Boulder, Colo., USA A new GSA Bulletin ... along the lower Rio Puerco and Chaco Wash in ... tree rings from salt cedar and willow, investigators were ... thick or greater. They then combined this data with ... reconstruct the history of these arroyos. , Arroyos are ...
(Date:9/18/2014)... system that can operate inside the bore of an ... a biomedical research partnership program at Brigham and Women,s ... the robot, in conjunction with real-time MRI images, can ... and less discomforting for the patient. The novel system ... with greater precision. , Developed by a team of ...
(Date:9/18/2014)... fall foliage season that prompts millions of Americans to undertake ... and possibly last a little longer within a century, according ... peeping in some areas of the United States as summer ... in the journal Global Ecology and Biogeography . For ... is the state tree of New Hampshire could change ...
Breaking Biology News(10 mins):Tree rings and arroyos 2Tree rings and arroyos 3Tree rings and arroyos 4Tree rings and arroyos 5Tree rings and arroyos 6Tree rings and arroyos 7Trial begins for MRI-compatible robot designed to improve accuracy of prostate biopsies 2Trial begins for MRI-compatible robot designed to improve accuracy of prostate biopsies 3Trial begins for MRI-compatible robot designed to improve accuracy of prostate biopsies 4Trial begins for MRI-compatible robot designed to improve accuracy of prostate biopsies 5Fall foliage season may be later, but longer on warmer Earth 2Fall foliage season may be later, but longer on warmer Earth 3Fall foliage season may be later, but longer on warmer Earth 4
... , A novel x-ray technique allowing the observation ... has been developed by a team of researchers from EPFL ... the research led by Professor Majed Chergui, head of EPFL,s ... at PSI appear online December 11 in the journal ...
... sea turtle,s first swim is the most critical of its life. ... it to the sea, the tiny voyager must also evade hungry ... hatching on the Great Barrier Reef,s coral cays the risks are ... deep waters. But how much does this headlong dash through the ...
... for the savanna elephants of Central Africa,s Sahel region, ... estimated 3,000 in 2006. Ivory poachers using automatic ... venture seasonally outside of the park. Civil unrest in ... park guards have been shot and killed in recent ...
Cached Biology News:Molecules in the spotlight 2Cost of hatchling turtles' dash for freedom 2Missing: 2,000 elephants 2
(Date:9/18/2014)... /PRNewswire/ - Oncothyreon Inc. (NASDAQ: ONTY ) ... separate underwritten offerings of 10,000,000 shares of its Common ... per share, for expected gross proceeds of $20 million ... Stock at a price to the public of $2,000.00 ... Each share of Series A Convertible Preferred Stock is ...
(Date:9/18/2014)... OMICS Group International invites researchers, authors ... the ‘Open Access Week’ by actively contributing their ... Pharma Journals from 20-26th October, 2014. , ... Sciences, accelerating with a tremendous speed to provide ... The industry is gearing with innovation and technological ...
(Date:9/18/2014)... be pretty expensive. Now a team led by an ... library of designs that will let scientists slash the ... syringe pump. , Syringe pumps are used to dispatch ... mixing chemicals in a reaction. They can also cost ... and his team of Michigan Tech students published the ...
(Date:9/18/2014)... touch in the course of a day - ... rely on the chemical industry to turn raw ... products into valuable chemicals that are the ingredients ... Sarina Sarina, who achieved outstanding progress in driving ... temperature using light instead of fossil fuels, has ...
Breaking Biology Technology:Oncothyreon Prices $40 Million Concurrent Public Offerings of Common Stock and Preferred Stock 2Oncothyreon Prices $40 Million Concurrent Public Offerings of Common Stock and Preferred Stock 3Pharma and Omics Journals to Address Global Challenges during Open Access Week 2Pharma and Omics Journals to Address Global Challenges during Open Access Week 3Doing science just got cheaper -- and faster 2Using solar energy to turn raw materials into ingredients for every day life 2
... 67% from Same Prior Year Period, DUBLIN, Calif., ... pharmaceutical company dedicated to the discovery and,development of novel ... and nine months ended September 30, 2008., Total ... compared,with $6.1 million for the same prior year period. ...
... a.m. EST, CHICAGO, Nov. 4 The Female Health ... Company,s Chief,Executive Officer, and Donna Felch, Chief Financial Officer, will ... at 9:55,a.m. Eastern Time on November 11, 2008. The Conference ... York City., A live audio webcast of the presentation ...
... Inc., a systems,biology company focused on identifying ... novel therapeutics and molecular diagnostics,today announced that ... Biomarker Consortium, a,public/private research partnership managed by ... (FNIH), and founded by the National,Institutes of ...
Cached Biology Technology:SuperGen Reports 2008 Third Quarter Financial Results 2SuperGen Reports 2008 Third Quarter Financial Results 3SuperGen Reports 2008 Third Quarter Financial Results 4SuperGen Reports 2008 Third Quarter Financial Results 5SuperGen Reports 2008 Third Quarter Financial Results 6SuperGen Reports 2008 Third Quarter Financial Results 7SuperGen Reports 2008 Third Quarter Financial Results 8SuperGen Reports 2008 Third Quarter Financial Results 9SuperGen Reports 2008 Third Quarter Financial Results 10The Female Health Company to Present at Rodman & Renshaw 10th Annual Global Investment Conference 2The Female Health Company to Present at Rodman & Renshaw 10th Annual Global Investment Conference 3Genstruct Added to The Biomarker Consortium's Rapidly Growing Roster of Industry Experts 2Genstruct Added to The Biomarker Consortium's Rapidly Growing Roster of Industry Experts 3
... GenomePlex Single Cell Whole Genome ... based on random fragmentation of genomic ... small fragments to PCR-amplifiable library molecules ... is achieved by PCR amplification of ...
Mouse monoclonal antibody to QARS - glutaminyl-tRNA synthetase...
Rabbit Anti-Mouse Ym1 Polyclonal Antibody,...
From formula-fed bovine calves Sterile, Cell culture tested...
Biology Products: