Navigation Links
Cleveland Clinic researcher discovers genetic cause of thyroid cancer
Date:12/23/2011

Friday, December 23, 2011, Cleveland: Cleveland Clinic researchers have discovered three genes that increase the risk of thyroid cancer, which is has the largest incidence increase in cancers among both men and women.

Research led by Charis Eng, M.D., Ph.D., Chair and founding Director of the Genomic Medicine Institute of Cleveland Clinic's Lerner Research Institute, included nearly 3,000 patients with Cowden syndrome (CS) or CS-like disease, which is related to an increased risk of breast and thyroid cancer.

Mutations in the PTEN gene are the foundation of Cowden syndrome. PTEN is a tumor suppressor gene, helping to direct the growth and division of cells. Inherited mutations in the PTEN gene have been found in approximately 80 percent of Cowden syndrome patients. These mutations prevent the PTEN protein from effectively regulating cell survival and division, which can lead to the formation of tumors.

"Our investigation into the genetics behind thyroid disease raises important details relevant to diagnosis and treatment," said Dr. Eng. "We hope to promote the earliest diagnosis and most targeted treatment possible."

The conclusions of this research, published in the Journal of Clinical Endocrinology & Metabolism, found that all six patients under age 18 had pathogenic PTEN mutations. The researchers recommend that the thyroids of children with PTEN mutation-causing CS-related disease receive increased surveillance.

Children with thyroid cancer are recommended to have testing for PTEN mutations, which could warrant surveillance for additional cancers or maladies. In contrast, alterations in the SDH and KLLN genes did not associate with thyroid cancer in children.

PTEN gene testing in the setting of genetic counseling is already routinely practiced, and has been a powerful gene-enabled diagnostic test which then personalizes clinical screening and treatment. Once SDH and KLLN findings are independe
'/>"/>

Contact: Dan Doron
dorond@ccf.org
216-312-0428
Cleveland Clinic
Source:Eurekalert

Page: 1 2

Related biology news :

1. Cleveland Clinic study discovers new targets for treating inflammatory, autoimmune diseases
2. Ohio Third Frontier awards $2.5 million for imaging research in Cleveland
3. Cleveland researchers collaborate to launch Phase 1 clinical trial for new MS treatment
4. Radiation from Japan detected in Cleveland
5. Cleveland Clinic researchers honored for contributions to science and technology
6. Draft sequence of Neandertal genome wins the 2010 AAAS Newcomb Cleveland Prize, supported by Affymetrix
7. Cleveland Museum of Natural History scientist announces new horned dinosaur
8. Cleveland Clinic, CWRU dental researcher finds switch that turns on the spread of cancer
9. HIV/AIDS vaccine developed at Western proceeding to human clinical trials
10. Identify clinically relevant fungi confidently and accurately
11. Global resource for clinical microbiologists and immunologists debuts
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/29/2014)... Washington, DC Monday, September 29: Between 1970 ... and fish around the globe dropped 52 percent, ... by World Wildlife Fund (WWF). This biodiversity loss ... increasing resource use of high-income countries. , In ... the report,s data point to other warning signs ...
(Date:9/29/2014)... CORVALLIS, Ore. Parents with children at home should ... from Oregon State University are recommending, after a new ... and asthma, asthma symptoms and chronic bronchitis. , "In ... the prevalence of asthma and wheezing is higher than ... ventilation," said Ellen Smit, an associate professor in the ...
(Date:9/29/2014)... Wis. Mountain pine beetles get a bad rap, ... killing pine trees over tens of millions of acres ... decade. , But contrary to popular belief, these ... wildfires like those that have recently swept through the ... in the ecological severity of fires than these bark-boring ...
Breaking Biology News(10 mins):Half of global wildlife lost, says new WWF report 2Childhood asthma linked to lack of ventilation for gas stoves, OSU study shows 2Childhood asthma linked to lack of ventilation for gas stoves, OSU study shows 3Tree killers, yes, fire starters, no: Mountain pine beetles get a bad rap, study says 2Tree killers, yes, fire starters, no: Mountain pine beetles get a bad rap, study says 3Tree killers, yes, fire starters, no: Mountain pine beetles get a bad rap, study says 4
... team has developed a promising nanomaterial-based biomedical device ... locally to sites where cancerous tumors have been ... which resembles a piece of plastic wrap and ... the potential to transform conventional treatment strategies and ...
... signals reveal an electromagnetic marker that predicts a ... discovered. "Such biomarkers that identify who will ... someday minimize trial-and-error prescribing and speed delivery of ... said Carlos Zarate, M.D., of the National Institute ...
... A group of researchers in Switzerland has published a study ... Journal Nature that shows how the cornea uses ... they demonstrate that everyday wear and tear on the cornea ... and that more serious repair jobs require the involvement of ...
Cached Biology News:Nanodiamond drug device could transform cancer treatment 2Nanodiamond drug device could transform cancer treatment 3Millisecond brain signals predict response to fast-acting antidepressant 2The role of stem cells in renewing the cornea 2
(Date:9/29/2014)... VIRGINIA BEACH, Va. , Sept. 29, 2014 ... scientists from the fields of cartilage repair, regeneration, ... as attendees from around the world gathered to ... 2014 LifeNet Health Institute of Regenerative Medicine symposium, ... Future Direction . Topics included Orthopedic Biosurgery, Minced ...
(Date:9/29/2014)... diseases and biodiversity loss requires evolutionary thinking, argues ... Express that was co-authored by Bruce Tabashnik ... and Life Sciences. , For the first time, ... progress in addressing a broad set of challenges ... that consider evolutionary histories and the likelihood of ...
(Date:9/29/2014)... , September 29, 2014 ... report "Epigenetics Market by Product (Modifying Enzymes, DNA ... Bisulphite Conversion Kit, Reagents), by Research Area ... Global Forecast to 2019", published by MarketsandMarkets, ... drivers, restraints, opportunities, current market trends, and ...
(Date:9/29/2014)... , Sept. 29, 2014  Atlas Venture, an ... sciences and technology innovation, today announced that Jason ... (NASDAQ: EPZM ), is joining the firm,s ... 1, 2014. At Atlas, Rhodes will work ... companies. He brings an accomplished record in company creation, ...
Breaking Biology Technology:World Renowned Experts Discuss Future Of Cartilage Regeneration 2World Renowned Experts Discuss Future Of Cartilage Regeneration 3Evolutionary biology: It's not just for textbooks anymore 2Evolutionary biology: It's not just for textbooks anymore 3Epigenetics Market Worth $783.17 Million by 2019 2Epigenetics Market Worth $783.17 Million by 2019 3Epigenetics Market Worth $783.17 Million by 2019 4Atlas Venture Names Jason Rhodes, Veteran Investor and President and CFO of Epizyme, As Partner on Life Sciences Investing Team 2
... Bioactive Small Molecules through ... ... today announced the addition of 1,300 bioactive small molecules to,its ... provides expanded data on the functional relationship between,bioactive small molecules ...
... Enable Healthcare ... Providers Access to PET Technology, HOFFMAN ... today announced its first molecular imaging,biomarker production facility in ... in and around Chennai to access the,positron emission tomography-computed ...
... Burke, MD, Executive Vice,President and Physician-in-Chief at The ... elected the 40th President of the Society of,Gynecologic ... March 9-12, 2008 in Tampa, Florida., Dr. ... Tulane,University in New Orleans, Louisiana. He served both ...
Cached Biology Technology:Sigma-Aldrich Partners With Sunset Molecular Discovery to Expand Your Favorite Gene Search Tool 2Siemens to Launch PETNET Services in India 2Siemens to Launch PETNET Services in India 3Thomas W. Burke, MD, Elected 40th President of the Society of Gynecologic Oncologists 2Thomas W. Burke, MD, Elected 40th President of the Society of Gynecologic Oncologists 3
... ChIP-on-chip Microarray is specifically designed for ... DNA binding proteins by pairing chromatin ... This set delivers robust hybridization and ... binding events and fewer false positives. ...
... White solid.. PACKAGED UNDER INERT GAS. Cyclizes ... is "driven" to completion. A protective agent for ... in many other preparations. Blocks the lethal and ... titration. Contaminants: Heavy metals: ≤1 ppm. ...
... genomics-based research with S. aureus, Sigma-Genosys has developed ... primers to amplify all open reading frames (ORFs) ... are included to amplify ORFs that are unique ... S. aureus. The ORFmer set contains primers to ...
... LabX light balance makes your life easier. It offers ... and management for one balance. *Instruments supported: ... AX, MX, UMX, AG, XS, XP, PR, SR, PG-S, ... *Job management: User ...
Biology Products: