Navigation Links
Cleveland Clinic research shows gut bacteria byproduct predicts heart attack and stroke
Date:4/24/2013

EMBARGOED UNTIL 5 P.M. EDT, WEDNESDAY, APRIL 24, 2013, Cleveland: A microbial byproduct of intestinal bacteria contributes to heart disease and serves as an accurate screening tool for predicting future risks of heart attack, stroke and death in persons not otherwise identified by traditional risk factors and blood tests, according to Cleveland Clinic research published today in The New England Journal of Medicine.

The research team was led by Stanley Hazen, M.D., Ph.D., Vice Chair of Translational Research, Chair of the Department of Cellular and Molecular Medicine for the Lerner Research Institute and section head of Preventive Cardiology & Rehabilitation in the Miller Family Heart and Vascular Institute at Cleveland Clinic, and W.H. Wilson Tang, M.D., Department of Cardiovascular Medicine in the Miller Family Heart and Vascular Institute and Lerner Research Institute.

The current study is an extension of Dr. Hazen's previous work, in which he found that a chemical byproduct called trimethylamine N-oxide (TMAO) is produced when intestinal bacteria digest the nutrient phosphatidylcholine, commonly known as lecithin. The prior research showed that TMAO levels in the blood were associated with heart disease. Dr. Hazen and colleagues have now confirmed that gut flora are essential in forming TMAO in humans and demonstrated a relationship between TMAO levels and future cardiac events like heart attack, stroke, and deatheven in those with no prior evidence of cardiac disease risk.

To demonstrate the role of gut flora in forming TMAO, human subjects were asked to eat two hard-boiled eggs (a common dietary source of lecithin) and a capsule of labeled lecithin (as a tracer). After ingestion, TMAO levels in the blood increased. However, when these same subjects were given a brief course of broad-spectrum antibiotics to suppress their gut flora, their TMAO levels were suppressed, and no additional TMAO was formed, even after ingesti
'/>"/>

Contact: Laura Ambro
ambrol@ccf.org
216-636-5876
Cleveland Clinic
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Cleveland Clinic researchers discover new link between heart disease and red meat
2. Cleveland Clinic research shows anemia drug does not improve health of anemic heart failure patients
3. Cleveland Clinic develops clinical screening program for no.1 genetic cause of colon cancer
4. Cleveland Clinic researchers receive $5 million grant to discover novel pathways to heart disease
5. Mayo Clinic anesthesiologist earns APSs Walter B. Cannon Award
6. Federal Government Organization achieves cleaner and faster Clinical Study Data using Tablet PCs from TabletKiosk
7. AACR news: Paragazole excels in preclinical models of triple-negative breast cancer
8. NYSCF scientists develop new protocol to ready induced pluripotent stem cell clinical application
9. ACMG releases report on incidental findings in clinical exome and genome sequencing
10. IUPUI stem cell research could expand clinical use of regenerative human cells
11. New AAN/ALS Association Clinical Fellow Will Pursue Immune Biomarkers
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/16/2014)... cultivated efficiently, they are anything but sustainable: environmental ... cultivation is becoming increasingly evident. Despite their disadvantages, ... are regarded as the sole possibility of achieving ... finds Bernhard Schmid, an ecology professor at the ... of agriculture and forestry. After all, a new ...
(Date:10/15/2014)... our ability to assess the pandemic risk from strains ... we must not allow ourselves to become complacent that ... international consortium of scientists. , Influenza pandemics arise when ... yet to develop widespread immunity – spreads in the ... the past 100 years, the worst of which – ...
(Date:10/15/2014)... 15, 2014 NXT-ID, Inc. (NASDAQ: NXTD ... on the growing mobile commerce market releases photos and video of ... on Monday October 13 th . Gino ... and angel investor Mr. Chad A. Verdi rang ... NXT-ID thanked his investors and employees "for their work and dedication ...
Breaking Biology News(10 mins):Plant communities produce greater yield than monocultures 2Plant communities produce greater yield than monocultures 3Scientists 'must not become complacent' when assessing pandemic threat from flu viruses 2Photo Release: NXT-ID Inc. Rings Opening Bell of the NASDAQ Stock Market October 13th 2Photo Release: NXT-ID Inc. Rings Opening Bell of the NASDAQ Stock Market October 13th 3
... landmark Cleveland institutions have come together to launch a ... sclerosis (MS). Researchers at the Cleveland Clinic, University Hospitals ... on a ground-breaking study that will test the feasibility ... to treat MS. In patients with MS, the ...
... Visualization" award in the "commercial" category of Illumina,s Data ... proud of. iDEA is Illumina,s program designed to challenge ... and data analysis techniques. "The iDEA challenge really ... heard about it. Genomatix is a scientific company at ...
... Tampa, FL (August 23, 2011) -- The first international ... of Pharmacy will focus on ways to improve health ... an individual,s genetic makeup. The 1st Annual International ... held Sept. 22 to 24 at the Dr. Kiran ...
Cached Biology News:Cleveland researchers collaborate to launch Phase 1 clinical trial for new MS treatment 2Cleveland researchers collaborate to launch Phase 1 clinical trial for new MS treatment 3Cleveland researchers collaborate to launch Phase 1 clinical trial for new MS treatment 4Cleveland researchers collaborate to launch Phase 1 clinical trial for new MS treatment 5International pharmacogenomics conference to focus on better drug treatment based on genetics 2
(Date:10/22/2014)... Shimadzu Scientific Instruments introduces its Open Solution ... pain management and clinical markets. The software increases the ... allowing users to highlight and review results that are ... analysts to filter results by group or based on ... the need to sift through analytes of no interest. ...
(Date:10/22/2014)... 2014 Currently offering a comprehensive ... D Weighing, Rice Lake, and Ohaus, Pipette.com has ... The Sartorius CPA Semi-Micro Balance is ideal for ... and user-friendly laboratory balance. , Sartorius is a ... laboratory balances are well known for their high ...
(Date:10/22/2014)... 22, 2014 According to new ... Service Type (Consulting, Integration, Deployment & Support), by ... Model (Public, Private, Others (Hybrid & Community)) - ... and segments the Cloud Professional Services Market into ... of revenues. It also identifies the drivers and ...
(Date:10/22/2014)... , Oct. 22, 2014 Nuvilex, Inc. ... approximately 400 million people worldwide are living with diabetes, ... people by 2030.  The global market for diabetes treatments ... approximately 330,000 people worldwide died from pancreatic cancer.  Pancreatic ... due to cancer in the United States ...
Breaking Biology Technology:Shimadzu Releases QuantAnalytics Open Access LCMS Software Package for Clinical Applications 2Pipette.com Launches the Addition of Sartorius CPA Semi-Micro Balance to Their Product Portfolio with Special Promotional Pricing 2Pipette.com Launches the Addition of Sartorius CPA Semi-Micro Balance to Their Product Portfolio with Special Promotional Pricing 3Cloud Professional Services Market by Public, Private, Hybrid & Community Expected to Reach $34.41 Billion by 2019 - New Report by MarketsandMarkets 2Cloud Professional Services Market by Public, Private, Hybrid & Community Expected to Reach $34.41 Billion by 2019 - New Report by MarketsandMarkets 3Cloud Professional Services Market by Public, Private, Hybrid & Community Expected to Reach $34.41 Billion by 2019 - New Report by MarketsandMarkets 4Cloud Professional Services Market by Public, Private, Hybrid & Community Expected to Reach $34.41 Billion by 2019 - New Report by MarketsandMarkets 5Nuvilex Brief Analyst Report: Thinking Outside the Box by BrokerBank Securities, Inc. 2
... 31 CryoLife, Inc. (NYSE: CRY ),a biomaterials, ... quarter and year end 2007 financial results will be,released ... a,teleconference call and live webcast at 10:00 a.m. Eastern ... a question and answer session,hosted by Steven G. Anderson, ...
... and clinicians identify best ... heart disease, BIRMINGHAM, Ala., Jan. 31 Clinical ... the need for more,detailed cholesterol testing, including direct measurement ... cardio-diagnostic company that,has developed an expanded cholesterol test called ...
... Reported Diluted Earnings per Share Increased 19% to $0.75. Diluted, Earnings per Share, ... ... Net Revenue Increased 10% to $22.4 Billion and Reported Diluted Earnings per Share Increased ... to ...
Cached Biology Technology:CryoLife Announces Release Date and Teleconference Call Details for the Fourth Quarter and Year End 2007 Financial Results 2Atherotech Says Detailed Cholesterol Test Can Help Doctors and Patients Choose Best Therapy 2Atherotech Says Detailed Cholesterol Test Can Help Doctors and Patients Choose Best Therapy 3Wyeth Reports Earnings Results for the 2007 Fourth Quarter and Full Year 2Wyeth Reports Earnings Results for the 2007 Fourth Quarter and Full Year 3Wyeth Reports Earnings Results for the 2007 Fourth Quarter and Full Year 4Wyeth Reports Earnings Results for the 2007 Fourth Quarter and Full Year 5Wyeth Reports Earnings Results for the 2007 Fourth Quarter and Full Year 6Wyeth Reports Earnings Results for the 2007 Fourth Quarter and Full Year 7Wyeth Reports Earnings Results for the 2007 Fourth Quarter and Full Year 8Wyeth Reports Earnings Results for the 2007 Fourth Quarter and Full Year 9Wyeth Reports Earnings Results for the 2007 Fourth Quarter and Full Year 10Wyeth Reports Earnings Results for the 2007 Fourth Quarter and Full Year 11Wyeth Reports Earnings Results for the 2007 Fourth Quarter and Full Year 12Wyeth Reports Earnings Results for the 2007 Fourth Quarter and Full Year 13Wyeth Reports Earnings Results for the 2007 Fourth Quarter and Full Year 14Wyeth Reports Earnings Results for the 2007 Fourth Quarter and Full Year 15
...
... This CLS number is a ... match Cornings product number. If showing ... the old Sigma-Aldrich number (R4276) or ... Material: cap polystyrene (expanded surface, easy ...
... Custom Peptide Services offer a full range ... research needs. Services include: Peptide synthesis, ... Peptide synthesis, purified product (70-95% pure) ... amidation, biotinylation, fluorescein, myristylation, phosphorylation, and rhodamine) ...
... ELISPOT (enzyme-lined immunospot) Kit analyzes interferon gamma ... A spot forms at the site where ... using a dissection microscope or automated ELISPOT ... of cells added to the microplate. This ...
Biology Products: