Navigation Links
Cleveland Clinic Children's Hospital launches study to genetically test for autism
Date:2/29/2012

Wednesday, Feb. 29, 2012, Cleveland: Cleveland Clinic Children's Hospital has launched a study to determine whether genetic markers can be used to help identify children who are at risk of developing autism.

The study is designed to confirm the predictive value of established genetic markers and is a follow-up to retrospective studies that have been completed.

Thomas Frazier, Ph.D., of Cleveland Clinic Children's Hospital Center for Autism, is the principle investigator for the study being funded by IntegraGen, a French biomedical company. The study will enroll 600 children over the next two years.

"This is the first time anyone has done a prospective study on a combination of genetic markers to examine whether a genetic risk score is helpful in identifying children with autism," Dr. Frazier said. "Autism is currently assessed by looking at behavioral characteristics of children. If we can develop a genetic test to assist in the earlier diagnosis of autism, we can provide beneficial treatment that leads to improved outcomes more quickly."

This study launches as the autism community prepares for the American Psychiatric Association's publication of the fifth edition of Diagnostic and Statistical Manual of Mental Disorders (DSM-5) in May 2013. Many experts expect the DSM will have a huge impact on autism spectrum disorders by narrowing the criteria for autism, eliminating Asperger syndrome and PDD-NOS (Pervasive Developmental Disorder-Not Otherwise Specified).

"A genetic risk assessment tool has the potential to ensure that high-functioning individuals, who are part of the autism spectrum, continue to be appropriately identified and receive necessary treatments," Dr. Frazier said.

Dr. Frazier's team will also study whether genetic changes may be associated with attention deficit/hyperactivity disorder. The study will enroll 300 children between the ages of 1 and 12 who are suspected to have an autism spectrum disorder, 75 children diagnosed with ADHD, and 225 children who do not have developmental disorders.

A cheek swab inside the mouth will be used to collect DNA from each study participant. Additionally, parents or caregivers will be asked to complete standardized questionnaires. Parents interested in finding out more information or enrolling their child in the study can contact the Cleveland Clinic Children's Hospital Center for Autism's Research Coordinator at (216) 448-6493.

The genetic testing will be done in the Genomic Medicine Institute at Cleveland Clinic's Lerner Research Institute. The study is being supported by a clinical research grant from IntegraGen, the company that developed the genetic panel being evaluated.


'/>"/>

Contact: Maureen Nagg
naggm@ccf.org
216-444-5703
Cleveland Clinic
Source:Eurekalert

Related biology news :

1. Cleveland Clinic joins 23andMe in the search for genetic clues to Parkinsons disease
2. Cleveland Clinic, Case Western Reserve University form research consortium
3. Cleveland Clinic researcher discovers genetic cause of thyroid cancer
4. Cleveland Clinic study discovers new targets for treating inflammatory, autoimmune diseases
5. Ohio Third Frontier awards $2.5 million for imaging research in Cleveland
6. Cleveland researchers collaborate to launch Phase 1 clinical trial for new MS treatment
7. Radiation from Japan detected in Cleveland
8. Cleveland Clinic researchers honored for contributions to science and technology
9. Draft sequence of Neandertal genome wins the 2010 AAAS Newcomb Cleveland Prize, supported by Affymetrix
10. Cleveland Museum of Natural History scientist announces new horned dinosaur
11. Cleveland Clinic, CWRU dental researcher finds switch that turns on the spread of cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/21/2016)... VANCOUVER, British Columbia , June 21, 2016 ... been appointed to the new role of principal ... has been named the director of customer development. ... , NuData,s chief technical officer. The moves reflect ... development teams in response to high customer demand ...
(Date:6/9/2016)... 9, 2016  Perkotek an innovation leader in attendance control systems is proud to ... hours, for employers to make sure the right employees are actually signing in, and ... ... ... ...
(Date:6/2/2016)... 2016 The Department of Transport Management ... 44 million US Dollar project, for the , ... Personalization, Enrolment, and IT Infrastructure , to ... and implementation of Identity Management Solutions. Numerous renowned international vendors ... Decatur was selected for the most compliant and ...
Breaking Biology News(10 mins):
(Date:6/24/2016)... DIEGO , June 24, 2016 ... more sensitively detects cancers susceptible to PARP inhibitors ... circulating tumor cells (CTCs). The new test has ... HRD-targeted therapeutics in multiple cancer types. ... targeting DNA damage response pathways, including PARP, ATM, ...
(Date:6/23/2016)... ... June 23, 2016 , ... UAS ... the launch of their brand, UP4™ Probiotics, into Target stores nationwide. The company, ... proud to add Target to its list of well-respected retailers. This list includes ...
(Date:6/23/2016)... , June 23, 2016 Houston Methodist ... the Cy-Fair Sports Association to serve as their ... agreement, Houston Methodist Willowbrook will provide sponsorship support, ... connectivity with association coaches, volunteers, athletes and families. ... the Cy-Fair Sports Association and to bring Houston ...
(Date:6/23/2016)... SAN FRANCISCO , June 23, 2016   ... it has secured $1 million in debt financing from ... to ramp up automation and to advance its drug ... for its new facility. "SVB has been ... goes beyond the services a traditional bank would provide," ...
Breaking Biology Technology: