Navigation Links
Cleveland Clinic, CWRU dental researcher finds switch that turns on the spread of cancer

Reporting in Nature Cell Biology, researchers describe the discovery of a specific protein called disabled-2 (Dab2) that switches on the process that releases cancer cells from the original tumor and allows the cells to spread and develop into new tumors in other parts of the body.

The process called epithelial-mesenchymal transdifferientiation (EMT) has been known to play a role in releasing cells (epithelial cells) on the surface of the solid tumor and transforming them into transient mesenchymal cell: cells with the ability to start to grow a new tumor.

This is often the fatal process in breast, ovarian, pancreatic and colon-rectal cancers.

Searching to understand how the EMT process begins, Ge Jin, who has joint appointments at the Case Western Reserve University School of Dental Medicine and the Lerner Research Institute at the Cleveland Clinic, began by working backwards from EMT to find its trigger.

The researchers found that a compound called transforming growth factor- (TGF-) triggers the formation of the Dab2 protein. It was this protein, Dab2, that activated the EMT process.

He discovered that when the researchers knocked out Dab2, EMT was not triggered.

"This is the major piece in cancer research that has been missing," Jin said.

Most tumors are epithelial in origin and have epithelial markers on their surface. The EMT process takes place when some of those cells dislodge from the surface and undergo a transformation into a fibrous mesenchymal cell maker with the ability to migrate.

"EMT is the most important step in this process," said Jin. He was part of a six-member research team, led by Philip Howe from the Department of Cancer Biology at the Lerner Research Institute in a National Cancer Institute-funded study.

The research group studied the biological processes that initiated the cancer spread by using cancer cells in animal models.

"It's a complicated cascade process," Jin said.

"If we can understand the signaling pathway for modulating EMT, then we can design drugs to delay or halt EMT cells and control tumor progression," Jin said.

Beyond cancer, Jin said. "The process we discovered may lead to understanding how other diseases progress."


Contact: Susan Griffith
Case Western Reserve University

Related biology news :

1. Natural product discovery by Cleveland medical researchers blocks tissue destruction
2. Cleveland Clinic leading clinical program to improve early-stage lung cancer detection
3. Small-scale fishing in Mexico rivals industrial fisheries in accidental turtle deaths
4. Dental chair a possible source of neurotoxic mercury waste
5. NYU dental professor discovers biological clock linking tooth growth to other metabolic processes
6. SAGE-Hindawi launch Journal of Dental Biomechanics
7. Lower your blood pressure, hydrate your skin and reduce dental plaque -- with chocolate?
8. Eastman Dental Center awarded $1.6 million to find ways to prevent cavities
9. New generation of orthopedic, dental and cardiovascular prostheses
10. Smart coating opens door to safer hip, knee and dental implants
11. University of Plymouth invests in dental research
Post Your Comments:
(Date:6/22/2016)... 22, 2016   Acuant , the ... solutions, has partnered with RightCrowd ® ... Visitor Management, Self-Service Kiosks and Continuous Workforce ... add functional enhancements to existing physical access ... venues with an automated ID verification and ...
(Date:6/21/2016)... , June 21, 2016 NuData Security announced ... new role of principal product architect and that ... director of customer development. Both will report directly ... officer. The moves reflect NuData,s strategic growth in ... to high customer demand and customer focus values. ...
(Date:6/16/2016)... SAN FRANCISCO , June 16, 2016 /PRNewswire/ ... Market size is expected to reach USD ... report by Grand View Research, Inc. Technological proliferation ... and banking applications are expected to drive the ... ) , The development of ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... ... June 23, 2016 , ... Charm ... Mold) microbial test has received AOAC Research Institute approval 061601. , “This is ... last year,” stated Bob Salter, Vice President of Regulatory and Industrial Affairs. “The ...
(Date:6/23/2016)... 2016   EpiBiome , a precision microbiome engineering ... debt financing from Silicon Valley Bank (SVB). The financing ... advance its drug development efforts, as well as purchase ... "SVB has been an incredible strategic partner to us ... bank would provide," said Dr. Aeron Tynes Hammack ...
(Date:6/23/2016)... ... ... In a new case report published today in STEM CELLS Translational Medicine, ... after being treated for breast cancer benefitted from an injection of stem cells derived ... debilitating, frequent side effect of cancer treatment. , Lymphedema refers to the ...
(Date:6/23/2016)... Andrew D Zelenetz ... Published recently in Oncology ... touchONCOLOGY, Andrew D Zelenetz , discusses the ... is placing an increasing burden on healthcare systems ... With the patents on many biologics expiring, interest ...
Breaking Biology Technology: