Navigation Links
Clemson bioengineer uses nanoparticles to target drugs
Date:10/8/2009

f their physical and chemical properties."

A handful of nanoparticle medicines already have been approved for use treating diseases, particularly cancers. Alexis and other bioengineers are ushering in a new era in medicine.

A challenge for oral medicines, for example, is getting them to do some good before the body destroys them. A patient's metabolism can do its job too well taking a drug out of circulation.

Called "first-pass metabolism," the liver breaks down a drug during its first trip circulating through the body. The result is doctors must use greater amounts of oral medicines to achieve the therapeutic effect. Negative reactions from the higher doses or the inconvenience from prolonged treatment cause many patients to stop taking their medicines.

Nanoparticles can be made to survive the first pass. The particles also can be made to get beyond the body's immune system. Multi-layers on the nanoparticles or nanoshells can resist the body's defenses, enabling the medicine to last longer or reach the intended location.

Dendrimers are nanoparticles that could become the Swiss Army knives of targeted drug delivery. The particles can be made so that a number of different kinds of molecules could be attached to it. One group of molecules could fight the disease, another could enhance images to track the drug, a third could carry a chemical trigger to release the medicine by command from outside the body, another, still, that could send signals about results.

"We are moving ahead in nanoscience in laboratories throughout the world," said Alexis. "Nanoparticle functionalities become more and more complex and the next step is for the research to develop technologies allowing their transfer from the research bench to a pharmaceutical drug. New ways of targeting drugs that will be more effective and safe and more agreeable to patients is just over the horizon."


'/>"/>

Contact: Peter Kent
pkent@clemson.edu
864-656-4355
Clemson University
Source:Eurekalert

Page: 1 2

Related biology news :

1. Clemson researchers study energy savings with electric cars and IntelliDrive technology
2. Clemson research nets $2 million from NSF to mimic natures probes
3. Clemson and collaborators receive $1.1 million to improve durability of concrete infrastructure
4. Clemson chemists present revolutionary teaching concepts
5. Clemson physicist Apparao Rao named Fellow of the American Physical Society
6. Clemson researchers advance nano-scale electromechanical sensors
7. US Senate confirms Clemson University engineering Dean Esin Gulari to National Science Board
8. National Science Foundation grants Clemson professors award to develop nanoprobes
9. NIH awards Clemson bioengineer $1.5 million to improve durability of tissue heart valves
10. Clemson bioengineer wins prestigious Early Career Award
11. NIH recognizes Clemson nanotechnology for molecule tracking
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/25/2015)... N.J. , June 25, 2015  TAKE Solutions ... a patent by the United States Patent and Trademark ... Standardization". This process leverages TAKE Solutions, Clinical Accelerators to ... over 50% (when compared to standardization without the accelerators), ... At the heart of ...
(Date:6/24/2015)... 2015 This report provides market analysis of ... years. It contains an analysis of the drivers, challenges, ... impact from the short, medium, and long term perspective ... market, and technology trends that currently, prevail in the ... authorities to efficiently manage the increasing marine traffic and ...
(Date:6/24/2015)... -- Research and Markets( http://www.researchandmarkets.com/research/hhwlfj/huawei_ascend ... "Huawei Ascend Mate 7 Fingerprint Sensor - Reverse ... Huawei,s technological choice for the fingerprint sensor ... and Samsung,s one. The Ascend Mate 7 presents ... a main actor in capacitive sensing human interface ...
Breaking Biology News(10 mins):TAKE Solutions Awarded Patent By USPTO 2Automatic Identification System Market by Class, by Platform, by Application and by Geography - Global Forecasts & Analysis to 2014 - 2020 2Huawei Ascend Mate 7 Fingerprint Sensor - Reverse Costing Analysis 2
... Jos Zanchetta, a member of the IOF Board and ... has been named the recipient of the prestigious Pierre ... Osteoporosis Foundation (IOF) in memory of Pierre D. Delmas, ... growth of the Foundation and osteoporosis advocacy worldwide. ...
... the damage caused by a heart attack survived in the ... a mouse model, researchers at The University of Texas MD ... Circulation Research . The study, with researchers at the ... imaging techniques developed by researchers at MD Anderson to track ...
... a 1600 km-wide ash cloud over the Atlantic. The ... visible in stark contrast to white clouds framing this ... emitting steam and ash on 20 March, wreaking havoc ... week caused some flights to be suspended to and ...
Cached Biology News:Transplanted adult stem cells provide lasting help to injured hearts 2Transplanted adult stem cells provide lasting help to injured hearts 3Transplanted adult stem cells provide lasting help to injured hearts 4
(Date:6/29/2015)... 2015 Elsevier , a ... and services, today announced the highlights of its journal ... Journal Citation Reports® (JCR) published by Thomson Reuters, Elsevier ... 2013 to 2014, ahead of the aggregate across other ... in 62 subject categories, up from 61 in 2013. ...
(Date:6/26/2015)... 2015 /PRNewswire/ - iCo Therapeutics ("iCo" or "the Company") ... nominees listed in the management information circular dated June ... Annual Meeting of Shareholders, held earlier today, June ... following 5 nominees proposed by management were elected ... the Company,s next Annual Meeting of Shareholders or ...
(Date:6/26/2015)... and MUMBAI, India , June ... NSE: TCS) a leading global IT services, consulting and ... as a Leader in Worldwide Life Sciences R&D Risk-Based ... " IDC MarketScape: Worldwide Life Science R&D Risk-Based Monitoring ... The report evaluated eight leading IT services ...
(Date:6/26/2015)... ... 26, 2015 , ... DNA Genotek, a leading provider of ... (Nasdaq: OSUR) today announced that it has awarded grants to three organizations that ... The company has awarded its OMNIgene®â€¢GUT fecal/stool collection kits and GenoFIND ...
Breaking Biology Technology:Elsevier Announces 2014 Citation Impact Highlights 2Elsevier Announces 2014 Citation Impact Highlights 3iCo Therapeutics Announces Voting & Election Results from Annual Meeting of Shareholders 2iCo Therapeutics Announces Voting & Election Results from Annual Meeting of Shareholders 3TCS Recognized as a Leader in Life Sciences R&D Risk-Based Monitoring by IDC MarketScape 2TCS Recognized as a Leader in Life Sciences R&D Risk-Based Monitoring by IDC MarketScape 3TCS Recognized as a Leader in Life Sciences R&D Risk-Based Monitoring by IDC MarketScape 4DNA Genotek Inc. Announces Recipients of Gut Microbiome Grant Program 2DNA Genotek Inc. Announces Recipients of Gut Microbiome Grant Program 3
... Companies will Present at the Largest Marketplace for Emerging ... and CTSI today announced that more than 100 leading ... partners will be showcased in the 4th Annual TechConnect ... R. Brown Convention Center in Houston, Texas. Held ...
... Development and InnovationMOUNTAIN VIEW, Calif., April 22 ... Pharmaceuticals & Biotechnology group assesses a variety of ... in cancer treatment. Physicians, nurses and patients ... reconstitution, home vs. office administration parameters, and barriers ...
... 22 GeneGo, Inc., a leading provider of software ... , today announced that the University of Cardiff has ... researchers will have access to GeneGo,s MetaCore, training and ... their partner relationship with GeneGo to provide a pathway ...
Cached Biology Technology:TechConnect Summit Brings the Global Technology Community to Houston, May 4-6, 2009 2TechConnect Summit Brings the Global Technology Community to Houston, May 4-6, 2009 3TechConnect Summit Brings the Global Technology Community to Houston, May 4-6, 2009 4Frost & Sullivan: Female Cancer Patients More Willing to Use Implantable Infusion Pumps Than Males 2Frost & Sullivan: Female Cancer Patients More Willing to Use Implantable Infusion Pumps Than Males 3Cardiff University Becomes a GeneGo Center of Excellence 2
...
cysteine and glycine-rich protein 2,...
... agent and DNA-topoisomersae II inhibitor (IC50 = 59.2 ... C 29 H 32 O 13 ... Store at: RT ... Soluble to 100 mM ...
HSPBP1 Antibody...
Biology Products: