Navigation Links
Clemson University study points to possible treatment for brain disorders
Date:10/22/2013

CLEMSON, S.C. Clemson University scientists are working to determine how neurons are generated, which is vital to providing treatment for neurological disorders like Tuberous Sclerosis Complex (TSC).

TSC is a rare genetic disease that causes the growth of tumors in the brain and other vital organs and may indicate such disorders as autism, epilepsy and cognitive impairment that may arise from the abnormal generation of neurons.

"Current medicine is directed at inhibiting the mammalian target of rapamycin (mTOR), a common feature within these tumors that have abnormally high activity," said David M Feliciano, assistant professor of biological sciences. "However, current treatments have severe side effects, likely due to mTOR's many functions and playing an important role in cell survival, growth and migration."

Feliciano and colleagues published their findings in journal Cell Reports.

"Neural stem cells generate the primary communicating cells of the brain called neurons through the process of neurogenesis, yet how this is orchestrated is unknown," said Feliciano.

The stem cells lie at the core of brain development and repair, and alterations in the cells' self-renewal and differentiation can have major consequences for brain function at any stage of life, according to researchers.

To better understand the process of neurogenesis, the researchers used a genetic approach known as neonatal electroporation to deliver pieces of DNA into neural stem cells in young mice, which allowed them to express and control specific components of the mTOR pathway.

The researchers found that when they increase activity of the mTOR pathway, neural stem cells make neurons at the expense of making more stem cells. They also found that this phenomenon is linked to a specific mTOR target known as 4E-BP2, which regulates the production of proteins.

Ultimately, this study points to a possible new treatment,
'/>"/>

Contact: David M. Feliciano
dfelici@clemson.edu
864-656-0435
Clemson University
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Clemson plant breeders roll out new oat variety
2. Clemson, Coastal Carolina universities to set hundreds of sensors in Savannah River
3. Clemson scholar receives top agriculture science award
4. Clemson plant pathologist working to raise cucurbit yields, lower production costs
5. Clemson University researchers: What happens to peaches when the chill is gone?
6. Clemson University researchers to study oil and gas operations impact on Gulf Coast pelicans
7. Clemson researchers: Different forage affects beef cattle weight, taste
8. University of Houston study shows BP oil spill hurt marshes, but recovery possible
9. University of Alberta led research may have discovered how memories are encoded in our brains
10. BGI, University of Helsinki and Wuhan University sign a MOU concerning cooperation on genomics
11. Marshall University study may lead to new treatments for prostate cancer
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Clemson University study points to possible treatment for brain disorders
(Date:10/15/2014)... -- NXT-ID, Inc. (NASDAQ: NXTD and NXTDW) ("NXT-ID" ... mobile commerce market releases photos and video of the recent opening ... 13 th . Gino Pereira , CEO ... investor Mr. Chad A. Verdi rang the bell.  ... investors and employees "for their work and dedication in bringing the ...
(Date:10/14/2014)... millions of years since T. rex took ... University scientists is breathing life back into dinosaurs using ... The research has important implications for how dinosaurs used ... the sense of smell and cool their brains. ... doctoral student Jason Bourke, lead author of the new ...
(Date:10/14/2014)... – October 14, 2014 – Scientists from The Scripps ... the National Institutes of Health (NIH) to lead an ... hemorrhagic fever disease in Africa. The study aims to ... some patients die, while others survive the inflection. ... the basic mechanism of how Lassa fever virus causes ...
Breaking Biology News(10 mins):Photo Release: NXT-ID Inc. Rings Opening Bell of the NASDAQ Stock Market October 13th 2Photo Release: NXT-ID Inc. Rings Opening Bell of the NASDAQ Stock Market October 13th 3Dinosaur breathing study shows that noses enhanced smelling and cooled brain 2Dinosaur breathing study shows that noses enhanced smelling and cooled brain 3Scripps Research Institute team receives $6.6 million to investigate deadly Lassa virus 2
... 2011) -- New findings from researchers at Harvard Medical School ... may shed light on the mechanisms that regulate the organization ... cell signaling not well understood at this time. ... CD36, a clustering-responsive class B scavenger receptor, as a model ...
... an early warning system developed in part by DOE,s ... the U.S. from the threats of insects, disease and ... multi-agency project uses high-performance computing to incorporate remote sensing ... weather data to identify abnormal vegetation patterns and the ...
... In a Memorandum of Understanding signed today, the European ... formalise their desire to maintain and further develop their ... and strengthened Memorandum of Understanding between the European Commission ... that it will set the stage for even better ...
Cached Biology News:
(Date:10/19/2014)... The Asia-Pacific Bromine Market report ... with analysis and forecast of revenue. , Browse ... Market report, to get an idea of the ... of the segmentation in the Asia-Pacific bromine market, ... , http://www.micromarketmonitor.com/market/asia-pacific-bromine-6741503144.html , Bromine is ...
(Date:10/19/2014)... 19, 2014 The Asia-Pacific Speech Analytics ... in Asia-Pacific with analysis and forecast of revenue. This ... 2014 to $208 million by 2019, at a Compound ... 2019. , Browse through the TOC of the Asia-Pacific ... the in-depth analysis provided. It also provides a glimpse ...
(Date:10/19/2014)... Asian Orthopedic braces and support systems report defines and segments ... revenue. The Orthopedic braces and support systems market in Asia ... at a developing CAGR of 4.4% from 2013 to 2018. ... and support systems market, to get an idea of the ... segmentation of orthopedic braces and support systems market in the ...
(Date:10/19/2014)... October 19, 2014 According to ... (Access Points; WLAN Controllers; Wireless gateways)]- Global Advancements, ... segments the global Outdoor Wi-Fi market with analysis ... report MarketsandMarkets also identifies the drivers and the ... the trends, opportunities and challenges. , Browse 65 ...
Breaking Biology Technology:The Asia-Pacific Bromine Market is estimated to grow to $4,080.1 million by 2018 - New Report by MicroMarket Monitor 2The Asia-Pacific Bromine Market is estimated to grow to $4,080.1 million by 2018 - New Report by MicroMarket Monitor 3The Asia-Pacific Speech Analytics market is estimated to reach $208 million by 2019 - New Report by MicroMarket Monitor 2The Asia-Pacific Speech Analytics market is estimated to reach $208 million by 2019 - New Report by MicroMarket Monitor 3The Asia-Pacific Speech Analytics market is estimated to reach $208 million by 2019 - New Report by MicroMarket Monitor 4The Asian Orthopedic braces and support systems market is estimated to grow to around $416.5 million by 2018 - New Report by MicroMarket Monitor 2The Asian Orthopedic braces and support systems market is estimated to grow to around $416.5 million by 2018 - New Report by MicroMarket Monitor 3The Asian Orthopedic braces and support systems market is estimated to grow to around $416.5 million by 2018 - New Report by MicroMarket Monitor 4Outdoor Wi-Fi Market (by Access Points, WLAN Controllers, Wireless gateways) Expected to Cross $37.2 Billion by 2018 - New Report by MarketsandMarkets 2Outdoor Wi-Fi Market (by Access Points, WLAN Controllers, Wireless gateways) Expected to Cross $37.2 Billion by 2018 - New Report by MarketsandMarkets 3Outdoor Wi-Fi Market (by Access Points, WLAN Controllers, Wireless gateways) Expected to Cross $37.2 Billion by 2018 - New Report by MarketsandMarkets 4
... Them Waiting, WASHINGTON, April 16 With dozens ... to meet with members of,Congress, The Coalition for a ... members to keep the best interests of,patients in mind ... for safe, effective and affordable biogeneric medicines., The ...
... N.Y., April 16 Biotech and pharma,companies are ... work, reports Genetic Engineering & Biotechnology News (GEN). ... means of testing drug,candidates for toxic effects, according ... GEN ( http://www.genengnews.com/articles/chitem.aspx?aid=2437 )., "Better screening technologies, ...
... 16 /PRNewswire-FirstCall/ - Chromos Molecular,Systems Inc. ("Chromos" or the ... restructuring efforts., The Board of Directors of Chromos ... President and Chief Executive Officer, effective,immediately. He has also ... of the Company, served as President and CEO since ...
Cached Biology Technology:Diverse Coalition of Purchasers Respond to BIO CEO Fly-In: There is Another Side to The Story 2Genetic Engineering & Biotechnology News Reports on Growing Use of Cell-Based Assays 2Chromos provides shareholder update 2
Human IL-17D Affinity Purified Polyclonal Ab...
BBS/Glycerol/Casein Block and Diluent - 10X Concentrate, 1 L...
... Immunogen: Synthetic peptide derived from an internal ... (Mammalian target of rapamycin FRAP RAFT1 RAPT1). ... protein. On Western blots it identifies ... Reactivity: Human (positive control: HEK293 cell lysates). ...
... to qualitatively detect EGFR ... paraffin-embedded (FFPE) tissue sections, ... cell preparations, using Chromogenic ... Fluorescent In Situ Hybridization ...
Biology Products: