Navigation Links
Clemson University biochemists identify new genetic code repair tool
Date:9/27/2011

CLEMSON, S.C. Clemson University researchers recently reported finding a new class of DNA repair-makers.

Clemson biochemist Weiguo Cao studies how cells repair damaged DNA. The finding from Cao's lab in the Clemson Biosystems Research Complex in collaboration with computational chemist Brian Dominy appeared in the Sept. 9 issue of The Journal of Biological Chemistry: "A new family of deamination repair enzymes in the uracil DNA glycosylase superfamily by Hyun-Wook Lee, Brian N. Dominy and Weiguo Cao."

"DNA is a string of a long molecule composed of four building blocks: A for adenine, T for thymine, G for guanine and C for cytosine. The heredity of all organisms is determined by the pairing of A with T and G with C," said Cao, a professor in the genetics and biochemistry department.

DNA is constantly assaulted by various stresses. A common type of damage is modification of three out of the four building blocks for genetic code, A, G, C by a chemical process called deamination. The genetic consequence of deamination is that it will change the pairing of the genetic code. For example, the deamination of C (cytosine) will generate U (uracil). Instead of pairing with G as C will do, U pairs with A. In so doing, it changes the genetic program inside the cell and may cause dangerous mutations resulting in disease.

To ensure the integrity of the genetic material, cells are equipped with a "molecular toolkit" for repairing DNA damage. The toolkit is comprised of a variety of different molecules called enzymes that have evolved to repair different types of DNA damage. One of the DNA repair enzymes the Cao lab studies is called uracil DNA glycosylase (UDG). As it's name indicates, it is traditionally known as an enzyme that removes uracil from DNA. Because deamination of C (cytosine) is a very common type of damage found in DNA, UDG has been found in many organisms and researchers have grouped them into five families in the s
'/>"/>

Contact: Weiguo Cao
wgc@clemson.edu
864-656-4176
Clemson University
Source:Eurekalert

Page: 1 2

Related biology news :

1. NIH awards Clemson bioengineer $1.5 million to improve durability of tissue heart valves
2. National Science Foundation grants Clemson professors award to develop nanoprobes
3. US Senate confirms Clemson University engineering Dean Esin Gulari to National Science Board
4. Clemson researchers advance nano-scale electromechanical sensors
5. Clemson physicist Apparao Rao named Fellow of the American Physical Society
6. Clemson chemists present revolutionary teaching concepts
7. Clemson and collaborators receive $1.1 million to improve durability of concrete infrastructure
8. Clemson research nets $2 million from NSF to mimic natures probes
9. Clemson researchers study energy savings with electric cars and IntelliDrive technology
10. Clemson bioengineer uses nanoparticles to target drugs
11. National Institutes of Health award Clemson $9.3 million for tissue regeneration center
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/25/2014)... WASHINGTON (July 24, 2014)The link between autism and ... the puzzle of the disease, and is largely ... Foundation Autism Research Initiative (SFARI), George Washington University ... to offer truly integrative and in-depth answers to ... research. , LaMantia, professor of pharmacology and ...
(Date:7/25/2014)... Prediabetes and Diabetes increasingly consume the healthcare ... immediate attention. , To address the ... impacting low-and middle-income countries, global leaders in ... research in diabetes prevention and development of ... important text. , This book on ...
(Date:7/25/2014)... After development of diffusion tensor tractography (DTT), which ... reconstruction and estimation for three motor tracts, such ... the corticoreticular pathway became possible. The corticospinal tract ... for motor function in the human brain. Several ... tract by transtentorial herniation. In addition, some studies ...
Breaking Biology News(10 mins):GW researcher receives grant to answer the how and why of autism during development 2What constitutes an effective response to the global 'diabesity' tsunami? 2
... and lizards likely gave birth to live young, rather than ... forth in their preferred reproductive mode, according to research published ... "This is a very unusual and controversial finding, and a ... Pyron, Robert F. Griggs Assistant Professor of Biology in the ...
... of millions of Americans, there,s no such thing as the ... hear a constant ringing, buzzing, hissing, humming or other noise ... be debilitating and life-altering. Now, University of Michigan ... what is going on inside their unquiet brains. The ...
... research indicates that for loggerhead sea turtles in the Northwest ... and favorable climate conditions in the year or two prior ... of nests produced by these animals in a given year. ... loggerheads, nesting increases since 2008 may be a recovery response ...
Cached Biology News:Ancestor of snakes, lizards likely gave birth to live young 2U-M tinnitus discovery opens door to possible new treatment avenues 2U-M tinnitus discovery opens door to possible new treatment avenues 3Loggerhead sea turtle nesting activity driven by recent climate conditions and returning nesting 2Loggerhead sea turtle nesting activity driven by recent climate conditions and returning nesting 3Loggerhead sea turtle nesting activity driven by recent climate conditions and returning nesting 4
(Date:7/25/2014)... , July 25, 2014 ... the "Global Metabolomics Market 2014-2018" report ... http://photos.prnewswire.com/prnh/20130307/600769 Metabolomics or Metabonomics is ... Metabolomics has become a new experimental technique that ... the environmental sciences. Metabolites are small molecules that ...
(Date:7/25/2014)... (PRWEB) July 25, 2014 WABC Radio show ... Pet with Lorry Young will be hosting California-based Vet-Stem, ... about stem cell therapy in pets. Dr. Harman first ... of stem cell therapy for pets suffering from osteoarthritis and ... Regenerative Veterinary Medicine industry forward. , Young has invited Dr. ...
(Date:7/25/2014)... Lawrence Livermore scientists Charles Westbrook and William ... " The World's Most Influential Scientific Minds ." , ... who were identified by analyzing citation data over the ... highest-impact work (2002-2012 and 2012-2013). The two were selected ... . , "This recognition is a great honor for ...
(Date:7/25/2014)... , July 25, 2014 /PRNewswire-iReach/ -- Xybion Corporation, ... for global corporations operating in highly regulated industries, ... first annual Global User Group Conference, Xybion International ... Philadelphia, Pennsylvania at the Sheraton ... http://photos.prnewswire.com/prnh/20140724/130263 This year,s conference ...
Breaking Biology Technology:Global Metabolomics Market 2014-2018: Key Vendors are Agilent, Bio-Rad, Bruker, Human Metabolome and Metabolon 2Robert J. Harman, DVM, Founder and CEO of Vet-Stem, Inc. to Join New York Radio Host Lorry Young in Upcoming Episode of A “Paws” For Your Pet 2Robert J. Harman, DVM, Founder and CEO of Vet-Stem, Inc. to Join New York Radio Host Lorry Young in Upcoming Episode of A “Paws” For Your Pet 3Scientists Burst onto Influential List for Combustion Research 2Scientists Burst onto Influential List for Combustion Research 3Scientists Burst onto Influential List for Combustion Research 4Xybion Announces It Will Host International User Conference in Philadelphia 2Xybion Announces It Will Host International User Conference in Philadelphia 3
... Pharmaceuticals, Inc. (NYSE Amex: ANX ) today ... ended December 31, 2008."2008 was a transition year for ... focused on lower-risk reformulations of previously-approved drugs. We achieved ... the difficult economic environment, we were unable to attract ...
... Insmed Inc. (Nasdaq: INSM ), a developer of ... March 23, 2009, NASDAQ issued a notice further extending the ... price and those rules requiring a minimum market value of ... effect through Friday, July 17, 2009, and the original rules ...
... /PRNewswire-FirstCall/ - Oncolytics Biotech Inc. ("Oncolytics") (TSX:ONC, NASDAQ: ... patient enrolment in its U.K. clinical trial to ... REOLYSIN(R) in combination with gemcitabine (Gemzar(R)) in patients ... neck. The principal investigators are Dr. Johann de ...
Cached Biology Technology:ADVENTRX Pharmaceuticals, Inc. Reports Fourth Quarter and Full Year 2008 Financial Results 2ADVENTRX Pharmaceuticals, Inc. Reports Fourth Quarter and Full Year 2008 Financial Results 3ADVENTRX Pharmaceuticals, Inc. Reports Fourth Quarter and Full Year 2008 Financial Results 4ADVENTRX Pharmaceuticals, Inc. Reports Fourth Quarter and Full Year 2008 Financial Results 5ADVENTRX Pharmaceuticals, Inc. Reports Fourth Quarter and Full Year 2008 Financial Results 6ADVENTRX Pharmaceuticals, Inc. Reports Fourth Quarter and Full Year 2008 Financial Results 7Insmed Announces That NASDAQ Further Extends Temporary Suspension of Minimum Bid Closing Price Rule 2Oncolytics Biotech(R) Inc. Completes Enrolment in Combination REOLYSIN(R)/Gemcitabine Trial 2Oncolytics Biotech(R) Inc. Completes Enrolment in Combination REOLYSIN(R)/Gemcitabine Trial 3
alpha/beta-Tubulin Antibody Ship: Hot Store: -20 C...
Anti-Kusabira Orange Monoclonal Antibody Description: 100 g Research Focus: tag Storage: -20C Shipping Temperature: 4C...
...
PURA Immunogen: PURA (NP_005850, 183 a.a. ~ 293 a.a) partial recombinant protein with GST tag. Storage: -20 C, Avoid Freeze/Thaw Cycles *Available for distribution in the US only...
Biology Products: