Navigation Links
Cleft lip corrected genetically in mouse model
Date:11/28/2011

NEW YORK (Nov. 28, 2011) -- Scientists at Weill Cornell Medical College used genetic methods to successfully repair cleft lips in mice embryos specially engineered for the study of cleft lip and cleft palate. The research breakthrough may show the way to prevent or treat the conditions in humans.

Cleft lip and cleft palate are among the most common birth defects, with treatment requiring multiple cycles of surgery, speech therapy and orthodontics. To date, there have been very few pre-clinical methods that allow researchers to study the molecular causes of these malformations. In particular, there has been a lack of animal models that accurately reflect the contribution of multiple genes to these congenital deformities in humans.

In a report in a recent issue of the journal Developmental Cell, Dr. Licia Selleri, associate professor of cell and developmental biology at Weill Cornell Medical College, and her co-authors report the first multigenic mouse model of cleft lip with or without cleft palate. The researchers uncovered the role of genes for Pbx (Pre-B Cell Leukemia Transcription Factor) proteins in coordinating cellular signaling behaviors crucial for the development of these abnormalities. They also discovered that altering one type of molecule within the Wnt signaling pathway (that comprises a network of proteins best known for their roles in embryogenesis) is sufficient to correct the defects.

Dr. Selleri has studied Pbx proteins for many years and has previously demonstrated their involvement in organ and skeletal development. In her latest study, she and her collaborators, including postdoctoral fellows Drs. Elisabetta Ferretti and Bingsi Li, tested whether these proteins also play a role in facial development by using mutant mice that lacked various combinations of three Pbx genes in the ectoderm, the embryonic cell layer that gives rise to the lip and nose.

The researchers found that only mutations affect
'/>"/>

Contact: Takla Boujaoude
tab2016@med.cornell.edu
212-821-0560
New York- Presbyterian Hospital/Weill Cornell Medical Center/Weill Cornell Medical College
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Cleft lip and palate: Genes more important than thought?
2. First trimester smoking linked to oral clefts
3. Study finds genetic variant plays role in cleft lip
4. Metabolic defects in mice corrected with transplanted embryonic neurons
5. Genetically corrected blood cells obtained from skin cells from Fanconi anemia patients
6. Iowa State University scientists genetically increase algae biomass by more than 50 percent
7. New American Chemical Society podcast: Genetically-engineered spider silk for gene therapy
8. The establishment of genetically engineered canola populations in the US
9. University of Colorado Cancer Center genetically sequences most common bladder cancer
10. Genetically engineered spider silk for gene therapy
11. Scientist urges government ruling on genetically engineered salmon
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... , Jan. 13, 2015  Today, FreeWavz ( ... launched its crowdfunding campaign on Fundable, https://www.fundable.com/freewavz ... build of production capacity to meet customer demand. ... Photo - http://photos.prnewswire.com/prnh/20150113/168790 ...
(Date:1/22/2015)... Jan. 15, 2015  BellBrook Labs, a leader in ... the launch of a TR-FRET (time resolved Forster ... UDP Assay, a high throughput screening assay for ... will allow for sensitive detection of hundreds of ...
(Date:1/22/2015)... NXTD and NXTDW) a biometric authentication company focused on ... Wocket™ smart wallet at CES 2015 in Las Vegas ... the "11 Hot Products at CES" in a review published in Wired.com, ... Newseveryday.com and "The top 10 gadgets from CES 2015" by Danny ...
Breaking Biology News(10 mins):FreeWavz Launches on Fundable to Drive Speed-to-Market in 2015 2BellBrook Labs Launches a High Throughput Screening Assay for Glycosyltransferases with TR-FRET Readout 2CES Response for NXT-ID's Wocket Smart Wallet Kicks Off 2015 2CES Response for NXT-ID's Wocket Smart Wallet Kicks Off 2015 3
... to transform ordinary sand a mainstay filter material used ... "super sand" with five times the filtering capacity of regular ... developing countries, where more than a billion people lack clean ... Applied Materials & Interfaces. Mainak Majumder and ...
... June 28-30, 2011 , the New York Academy of ... wide range of subspecialties, in addition to patients and ... our understanding of the clinical features, management, and treatment ... systems and affecting children and young adults. The ...
... Troy, N.Y. A new technique developed at Rensselaer ... biochemical information from nanoscale bone samples. Along ... osteoporosis, this innovation opens up an entirely new proteomics-based ... the archeological and forensic study of human skeletons. ...
Cached Biology News:New York Academy of Sciences hosts a conference on rare disease Shwachman-Diamond Syndrome 2New technique yields troves of information from nanoscale bone samples 2New technique yields troves of information from nanoscale bone samples 3
(Date:3/5/2015)... The next implants made from the PEEK-OPTIMA® ... (European) approval. The CE mark is necessary for distributing ... the European Union. Following the Class IIb approval route, ... supplied by the Turkey-based company Osimplant for the treatment ... Expandable Bladed HA PEEK Cage line of spinal implants, ...
(Date:3/4/2015)... , March 4, 2015 The UPMC Center ... 2015 Fellows in the Emerging Leaders in Biosecurity Initiative ... leaders in the field of biosecurity, UPMC has selected ... a wide array of backgrounds, including biological science, medicine, ... "With the vision and support of ...
(Date:3/4/2015)... --Research and Markets ( http://www.researchandmarkets.com/research/jspg2c/global_biologics ) ... Biologics and Biosimilars Industry Report 2015" report ... Global Biologics and Biosimilars Industry Report 2015 is ... state of the biologics and biosimilars industry. ... the industry including definitions, classifications, applications and industry ...
(Date:3/4/2015)... 4, 2015 AcelRx Pharmaceuticals, Inc. (Nasdaq: ... focused on the development and commercialization of innovative ... pain, today announced that it will release fourth ... close on Monday, March 9th, 2015. AcelRx management ... p.m. Eastern Time (1:30 p.m. Pacific Time) on ...
Breaking Biology Technology:Invibio’s PEEK-OPTIMA® HA Enhanced Gains Momentum: New Implant Receives European Approval 2Invibio’s PEEK-OPTIMA® HA Enhanced Gains Momentum: New Implant Receives European Approval 3UPMC Center for Health Security Announces 2015 Emerging Leaders in Biosecurity 2UPMC Center for Health Security Announces 2015 Emerging Leaders in Biosecurity 3Global Biologics and Biosimilars Industry Report 2015-2020 2AcelRx Pharmaceuticals to Hold Annual 2014 Financial Results Conference Call and Webcast on Monday, March 9th, 2015 2AcelRx Pharmaceuticals to Hold Annual 2014 Financial Results Conference Call and Webcast on Monday, March 9th, 2015 3
... Aureus Pharma, a leading provider of,knowledge management ... release today of the new software solution ... evaluate target, cell and,drug profiles using bio-assays ... Pharma,s AurSCOPE Target Knowledge databases. AurPROFILER has ...
... Inc., the,operating company of WuXi PharmaTech (NYSE: ... of Garry Takle, Ph.D. as Vice President of ... Testing Services for its,Philadelphia facility., (Logo: ... with the company for nine years in roles ...
... HILL, N.C., Aug. 15 The U.S. ... into multiple market,segments. In this challenging marketplace, ... complex organizational and,decision-making structures to effectively represent ... being influenced by medical professionals,focused on efficacy ...
Cached Biology Technology:Aureus Pharma Releases AurPROFILER(R) - a New and Powerful Pharmacology Profiling Solution 2WuXi AppTec Appoints Garry Takle, Ph.D. as VP of Operations and Joseph Hughes, Ph.D. as VP of Testing Services for Philadelphia Facility 2U.S. Hospital Sales Opportunities Maximized Through Functional Optimization 2
... CE-based system provides clear advantages over ... load, gene expression), mutation analysis, and ... system with microplate connectivity is ideal ... quality control. The P/ACE Series ...
The imaging screen-K (Kodak), is a 35 x 43 cm storage phosphor screen that is used for the quantitation and imaging of 32P, 33P, 35S, 14C, and 3H....
The filter 695RDF55 Reflect 635 for the Molecular Imager FX is a band pass filter for Cy5 and Alexa Fluor 635 dyes....
... Kit is a 2-color staining method for ... to detect apoptotic cells by flow cytometry. ... required for measuring apoptosis in cells, including ... reagent performance; washing, reaction and rinsing buffers ...
Biology Products: