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Cleft lip and palate: Genes more important than thought?
Date:3/8/2009

rence of clefts.

Good news for mothers of children affected

'Without this genetic factor on chromosome 8, the probability of a child in our population of getting clefts would be significantly less than 1 in 700,' Elisabeth Mangold points out. 'In effect, this is good news for all mothers of the children affected, who always thought, "I must have done something wrong while I was pregnant." You just can't help having the genes you have got.'

Further research now aims to show which gene exactly on chromosome 8 is responsible and how it works. 'We are currently looking for it,' Dr. Mangold explains. 'It could indeed be what is known as a regulatory element that controls other genes.' When the mechanisms of all the genes involved and the interplay with environmental factors are understood, the scientists can also say whether prophylaxis involving medication during pregnancy makes sense. There are currently several indications that taking particular vitamins during pregnancy can counteract deformities in embryos.


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Contact: Dr. Elisabeth Mangold
e.mangold@uni-bonn.de
49-022-828-722-286
University of Bonn
Source:Eurekalert

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