Navigation Links
Clean sampling from bioreactors
Date:3/11/2010

In its collective efforts to develop new drugs, the pharmaceuticals industry is making increasing use of biotechnology based on the application of natural biological transformation processes. One of the most important methods is the cultivation of microorganisms or cells in a bioreactor filled with a liquid culture medium. As drug manufacture is subject to especially strict regulations, the conditions inside the bioreactor need to be monitored precisely. Possibilities for analysis inside the reactor itself are extremely limited due to the need for thorough sterilization, with either steam or gamma rays. The use of external analyzers is therefore absolute necessary. Probes are used to check the cultivation: the probes extract samples from the medium and transfer them to an analytical system, which analyzes relevant parameters. However, a key problem with conventional sampling systems is the fact that they cause an unnecessary loss of medium in the bioreactor and often contaminate and distort the samples owing to a lack of sterility.

bbi-biotech now offers completely novel sampling systems capable of taking sterile samples from bioreactors without incurring any dead volume. The sterile boundary is in the reactor itself. Pre-rinsing is therefore not required in order to obtain a representative sample. The system consists of a disposable probe, a pump, a pneumatic unit and an innovative control mechanism. The sampling system extracts from the bioreactor no more than the quantity needed for the analysis or quality control step. The innovative way in which the sample is transported using sterile gas facilitates the automatic cleaning of the conduit system. An optional rinse can in every case prevent contamination or distortion of consecutive samples. Furthermore, the fully automatable sampling procedure can be kept very short with the help of the novel system that turns offline analysis into atline analysis. With the data being measured in real time, the status of the process can be determined immediately, or almost in real time, and regulated at once. "The new sampling systems can be employed in all process engineering applications, in other words processes in which microorganisms, for instance, are used to create a product by means of biological methods, in the biotech, pharmaceuticals, food and cosmetics industries. They work with bioreactors of all sizes and can be connected to any type of analysis instrument, including flow cytometers, enzyme sensors, mass spectrometers, HPLC and bioarrays. We thereby help protect our customers' investments in their existing equipment," explains bbi-biotech's CEO Bernd-Ulrich Wilhelm. According to Bernd Ctortecka, Patent and License Manager at Max Planck Innovation, bbi-biotech is an "innovative provider of exclusive technologies in the production of scientific instruments. The company is even in a position to supply its customers with customized, one-stop solutions for process engineering applications, including bioreactors. Our patent is a key component in the company's strategy and presents bbi-biotech's customers with completely new possibilities for monitoring, checking and managing cultivation quality."


'/>"/>

Contact: Markus Berninger
berninger@max-planck-innovation.de
49-892-909-1930
Max-Planck-Gesellschaft
Source:Eurekalert

Related biology news :

1. Genetically engineered tobacco plant cleans up environmental toxin
2. Orange peels, newspapers may lead to cheaper, cleaner ethanol fuel
3. Industrial cleaner linked to increased risk of Parkinsons disease
4. Habit-learning device will lower energy bills under new clean energy cashback scheme
5. Uniform analyses for clean drinking water in Europe
6. Research is vital to a cleaner, greener, low carbon future
7. Genomic research will enable greener cleanup of military explosive test sites
8. RIT scientist shines laser light on methane in pursuit of clean fuel
9. Developing enzymes to clean up pollution by explosives
10. LLNL technology cleans up Visalia Superfund 100 years ahead of schedule
11. Hot microbes cause groundwater cleanup rethink
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/30/2017)... , June 30, 2017 Today, American ... and supplier of face and eye tracking software, ... Product provider program. "Artificial intelligence ... way to monitor a driver,s attentiveness levels while ... being able to detect fatigue and prevent potential ...
(Date:5/16/2017)... TEANECK, N.J. , May 16, 2017  Veratad ... leading provider of online age and identity verification solutions, ... the K(NO)W Identity Conference 2017, May 15 thru May ... Ronald Regan Building and International Trade Center. ... across the globe and in today,s quickly evolving digital ...
(Date:4/19/2017)... The global military biometrics market ... by the presence of several large global players. The ... major players - 3M Cogent, NEC Corporation, M2SYS Technology, ... 61% of the global military biometric market in 2016. ... military biometrics market boast global presence, which has catapulted ...
Breaking Biology News(10 mins):
(Date:7/25/2017)... ... July 25, 2017 , ... Fiberstar, Inc ., a global market ... Citri-Fi® 125. This natural citrus fiber is used to improve tomato-based food products by ... sauces, condiments and spreads. Today, more than ever, consumers connect ingredients to the foods ...
(Date:7/24/2017)... ... ... Charm Sciences, Inc. is pleased to announce the Charm® ROSA® Tetracycline-SL (Dilution ... (NCIMS) Laboratory Committee and Appendix N Committee as a drug residue test kit for ... voted at its annual meeting in April, 2015 to establish a pilot program to ...
(Date:7/24/2017)... ... July 24, 2017 , ... ... the stock market news outlet had initiated coverage on Interpace Diagnostics. Interpace ... and identifies exposure, progression and risk analysis from specific cancers in humans. ...
(Date:7/20/2017)... ... 20, 2017 , ... Dr. Asher Kimchi, Founder and Chairman of the ... Awards at the 22nd World Congress on Heart Disease held in Vancouver, BC, Canada. ... the Distinguished Fellowship Awards. , Dr. Asher Kimchi, together with Co-Chairmen Dr. John A. ...
Breaking Biology Technology: