Navigation Links
Clean sampling from bioreactors
Date:3/11/2010

In its collective efforts to develop new drugs, the pharmaceuticals industry is making increasing use of biotechnology based on the application of natural biological transformation processes. One of the most important methods is the cultivation of microorganisms or cells in a bioreactor filled with a liquid culture medium. As drug manufacture is subject to especially strict regulations, the conditions inside the bioreactor need to be monitored precisely. Possibilities for analysis inside the reactor itself are extremely limited due to the need for thorough sterilization, with either steam or gamma rays. The use of external analyzers is therefore absolute necessary. Probes are used to check the cultivation: the probes extract samples from the medium and transfer them to an analytical system, which analyzes relevant parameters. However, a key problem with conventional sampling systems is the fact that they cause an unnecessary loss of medium in the bioreactor and often contaminate and distort the samples owing to a lack of sterility.

bbi-biotech now offers completely novel sampling systems capable of taking sterile samples from bioreactors without incurring any dead volume. The sterile boundary is in the reactor itself. Pre-rinsing is therefore not required in order to obtain a representative sample. The system consists of a disposable probe, a pump, a pneumatic unit and an innovative control mechanism. The sampling system extracts from the bioreactor no more than the quantity needed for the analysis or quality control step. The innovative way in which the sample is transported using sterile gas facilitates the automatic cleaning of the conduit system. An optional rinse can in every case prevent contamination or distortion of consecutive samples. Furthermore, the fully automatable sampling procedure can be kept very short with the help of the novel system that turns offline analysis into atline analysis. With the data being measured in real time, the status of the process can be determined immediately, or almost in real time, and regulated at once. "The new sampling systems can be employed in all process engineering applications, in other words processes in which microorganisms, for instance, are used to create a product by means of biological methods, in the biotech, pharmaceuticals, food and cosmetics industries. They work with bioreactors of all sizes and can be connected to any type of analysis instrument, including flow cytometers, enzyme sensors, mass spectrometers, HPLC and bioarrays. We thereby help protect our customers' investments in their existing equipment," explains bbi-biotech's CEO Bernd-Ulrich Wilhelm. According to Bernd Ctortecka, Patent and License Manager at Max Planck Innovation, bbi-biotech is an "innovative provider of exclusive technologies in the production of scientific instruments. The company is even in a position to supply its customers with customized, one-stop solutions for process engineering applications, including bioreactors. Our patent is a key component in the company's strategy and presents bbi-biotech's customers with completely new possibilities for monitoring, checking and managing cultivation quality."


'/>"/>

Contact: Markus Berninger
berninger@max-planck-innovation.de
49-892-909-1930
Max-Planck-Gesellschaft
Source:Eurekalert

Related biology news :

1. Genetically engineered tobacco plant cleans up environmental toxin
2. Orange peels, newspapers may lead to cheaper, cleaner ethanol fuel
3. Industrial cleaner linked to increased risk of Parkinsons disease
4. Habit-learning device will lower energy bills under new clean energy cashback scheme
5. Uniform analyses for clean drinking water in Europe
6. Research is vital to a cleaner, greener, low carbon future
7. Genomic research will enable greener cleanup of military explosive test sites
8. RIT scientist shines laser light on methane in pursuit of clean fuel
9. Developing enzymes to clean up pollution by explosives
10. LLNL technology cleans up Visalia Superfund 100 years ahead of schedule
11. Hot microbes cause groundwater cleanup rethink
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/5/2017)... 2017  The Allen Institute for Cell Science today ... one-of-a-kind portal and dynamic digital window into the human ... first application of deep learning to create predictive models ... and a growing suite of powerful tools. The Allen ... future publicly available resources created and shared by the ...
(Date:4/4/2017)... 4, 2017   EyeLock LLC , a leader ... United States Patent and Trademark Office (USPTO) has issued ... linking of an iris image with a face image ... the company,s 45 th issued patent. ... timely given the multi-modal biometric capabilities that have recently ...
(Date:3/30/2017)... -- The research team of The Hong Kong Polytechnic ... by adopting ground breaking 3D fingerprint minutiae recovery and matching technology, ... accuracy for use in identification, crime investigation, immigration control, security of ... ... A research team led by Dr ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... ... October 11, 2017 , ... The ... endogenous context, enabling overexpression experiments and avoiding the use of exogenous expression plasmids. ... is transformative for performing systematic gain-of-function studies. , This complement to loss-of-function ...
(Date:10/11/2017)... ... 11, 2017 , ... Proscia Inc ., a data ... titled, “Pathology is going digital. Is your lab ready?” with Dr. Nicolas Cacciabeve, ... and how Proscia improves lab economics and realizes an increase in diagnostic confidence.* ...
(Date:10/11/2017)... ... ... Disappearing forests and increased emissions are the main causes of the evolving air ... living in larger cities are affected by air pollution related diseases. , That is ... globally - decided to take action. , “I knew I had to take action ...
(Date:10/10/2017)... , ... October 10, 2017 , ... San Diego-based team ... its corporate rebranding initiative announced today. The bold new look is part of ... the company moves into a significant growth period. , It will also expand its ...
Breaking Biology Technology: