Navigation Links
Claudin 11 stops the leaks in neuronal myelin sheaths
Date:12/1/2008

Devaux and Gow demonstrate how a tight junction protein called claudin 11 makes the neuronal myelin sheath a snug fit. The study will be published in the December 1, 2008 issue of the Journal of Cell Biology (www.jcb.org).

Like the rubber coating on a copper wire, the myelin sheatha membrane extension of glial cells that spirals around the axons of neuronscreates an insulation layer that prevents current leakage from axons and aids electrical conduction along the length of the axon.

Claudin 11 forms tight junctions between successive spiral layers of the myelin sheath, but it was unknown whether it was required for myelin to act as a good insulator. To examine this question, Devaux and Gow compared electrical recordings from the optic nerve of wild-type and claudin 11 knockout mice. They found that although claudin 11 deficiency caused no gross defects in the appearance of the myelin sheath, it slowed electrical signalsat least in neurons with small-diameter axons.

Using a computer model that incorporates the resistive and capacitive properties of axons (and their myelin sheaths), the authors showed that claudin 11 adds to the electrical resistance of myelin by preventing leakage of charged ions (and electrical current) through the spiral space between myelin layers. The reduced resistance in the absence of claudin 11 affects small-diameter axons most severely because such axons have thinner myelin sheaths and thus less insulation to begin with. Because neurons with small-diameter axons are mostly found in the CNS, the authors speculate that defects in claudin 11 could be associated with deficits in cognition and perception, like those found in schizophrenia or neurodegenerative diseases.


'/>"/>

Contact: Rita Sullivan
rsullivan@rockefeller.edu
212-327-8603
Rockefeller University Press
Source:Eurekalert

Page: 1

Related biology news :

1. Purdue researcher invents molecule that stops SARS
2. Nothing stops an expert in the art of living
3. Early treatment stops epilepsy in its tracks
4. Chemical in red wine, fruits and vegetables stops cancer, heart disease, depending on the dose
5. How neuronal activity leads to Alzheimers protein cleavage
6. Researchers uncover mechanism of action of antibiotic able to reduce neuronal cell death in brain
7. Neuronal circuits able to rewire on the fly to sharpen senses
8. Neuronal conduction of excitation without action potentials based on ceramide production
9. Carnegie Mellon scientists investigate initial molecular mechanism that triggers neuronal firing
10. Intraspinal implant of mesenchymal stem cells may not heal the demyelinated spinal cord
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/30/2017)... -- The research team of The Hong Kong Polytechnic ... by adopting ground breaking 3D fingerprint minutiae recovery and matching technology, ... accuracy for use in identification, crime investigation, immigration control, security of ... ... A research team led by Dr ...
(Date:3/27/2017)... , March 27, 2017  Catholic Health ... and Management Systems Society (HIMSS) Analytics for achieving ... Adoption Model sm . In addition, CHS previously ... U.S. hospitals using an electronic medical record (EMR). ... its high level of EMR usage in an ...
(Date:3/23/2017)... DUBLIN , Mar. 23, 2017 Research ... Anti-Theft System Market Analysis & Trends - Industry Forecast to 2025" ... ... to grow at a CAGR of around 8.8% over the next ... This industry report analyzes the market estimates and forecasts for all ...
Breaking Biology News(10 mins):
(Date:4/21/2017)... ... ... Having worked on the design of the innovative Triton™ lab bench ... lab design architects from around the country at the Lab Design Conference 2017 in ... Greg Casey will be at the show, where they will highlight the unique elements ...
(Date:4/21/2017)... ... April 21, 2017 , ... ... to nourishing a range of emerging bio and technology start-ups, is hosting “Celebration ... 2017. This double event will start with libations and networking at 3:30 p.m. ...
(Date:4/20/2017)... 20, 2017  Eli Lilly and Company (NYSE: ... galcanezumab for the prevention of migraine at the American ... place April 22-28, 2017, in Boston ... at AAN, including safety and patient outcomes data for ... a reduction in monthly migraine headache days among patients ...
(Date:4/20/2017)... /PRNewswire/ - Prometic Life Sciences Inc. (TSX: PLI) (OTCQX: PFSCF) ("Prometic" ... Liver Congress ("ILC") 2017 of the European Association for the ... on the positive effects of PBI-4050 on reduction of ... metabolic syndrome. ... Dr. Lyne Gagnon, Vice-President of R&D Pre-clinical of Prometic "This ...
Breaking Biology Technology: