Navigation Links
Circuitry of cells involved in immunity, autoimmune diseases exposed
Date:3/6/2013

iology at MIT. Regev is also an Early Career Scientist at Howard Hughes Medical Institute and the director of the Klarman Cell Observatory at the Broad. "The value in doing an unbiased analysis is that we're able to understand a lot more about the molecular biology at play and identify novel players in this process."

Th17 cells can promote inflammation that is important for protection against pathogens, but they have also been implicated in diseases like multiple sclerosis, psoriasis, rheumatoid arthritis, and ankylosing spondylitis. Treatment options for some of these diseases, such as psoriasis, include manipulating T cell function.

David Hafler's group at Yale University studies human autoimmune diseases in general and the role of Th17 cells in particular, and has collaborated with Kuchroo's group for many years. "These are not diseases of bad genes alone or diseases caused by the environment, but diseases of a bad interaction between genes and the environment," said Hafler, Gilbert H. Glaser Professor of Neurology, professor of immunobiology, chair of Department of Neurology, and senior author of one of this week's Nature papers.

Some genes have been previously tied to Th17 development, but the research team wanted a more comprehensive view. One of the challenges of studying cell development, however, is that cells, particularly immune cells, change and evolve over time. The researchers chose to take frequent snapshots 18 over the course of three days to see what was happening within the T cells as they grew from nave cells into more specialized Th17 cells. From these snapshots, they used computational algorithms to begin to stitch together a network of molecular changes happening as the cells matured.

With this initial information in hand, the researchers systematically tested their model by silencing genes one-by-one, which could help reveal the most important points in the network and untangle their biological me
'/>"/>

Contact: Haley Bridger
hbridger@broadinstitute.org
617-714-7968
Broad Institute of MIT and Harvard
Source:Eurekalert

Page: 1 2 3 4 5

Related biology news :

1. Brain circuitry is different for women with anorexia and obesity
2. 1 region, 2 functions: Brain cells multitasking key to understanding overall brain function
3. U of M researchers utilize genetically corrected stem cells to spark muscle regeneration
4. Brain adds cells in puberty to navigate adult world
5. Novel combination therapy shuts down escape route, killing glioblastoma tumor cells
6. Scientists find bone-marrow environment that helps produce infection-fighting T and B cells
7. Engineering cells for more efficient biofuel production
8. Bone marrow cells used in bladder regeneration
9. Why cells stick: Phenomenon extends longevity of bonds between cells
10. Long noncoding RNAs control development of fat cells
11. Research improving breast cancer treatment by targeting tumor initiating cells
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/31/2015)... Growing need for data security ... projects to drive India biometrics market ... report, " India Biometrics Market Forecast & Opportunities, 2020 ", ... to grow at a CAGR of over 35% during 2015 ... of extensive use of biometric technology in the government sector. ...
(Date:8/25/2015)... CITY and BELLEVUE, Wash. ... leader in advanced robotic systems, announced today it will ... unmanned ground vehicle (UGV), at the National Tactical Officers ... The Guardian S is the first-ever ... culmination of years of research and in-field trials and ...
(Date:8/20/2015)... , Aug. 20, 2015   Sensory, Inc ... improving the user experience and security of consumer ... today announced that its TrulySecure™ is ... software to be FIDO Certified™. The ... compliance with the FIDO UAF (Universal Authentication Framework) ...
Breaking Biology News(10 mins):India Biometrics Market to Grow at Over 35% Through 2020, Says TechSci Research 2India Biometrics Market to Grow at Over 35% Through 2020, Says TechSci Research 3Sarcos to Debut First-of-its-Kind Snake Robot 2Sarcos to Debut First-of-its-Kind Snake Robot 3TrulySecure From Sensory Becomes First Face and Voice Biometrics Technology to be FIDO UAF Certified 2TrulySecure From Sensory Becomes First Face and Voice Biometrics Technology to be FIDO UAF Certified 3TrulySecure From Sensory Becomes First Face and Voice Biometrics Technology to be FIDO UAF Certified 4TrulySecure From Sensory Becomes First Face and Voice Biometrics Technology to be FIDO UAF Certified 5
... Hopkins scientists about how a single-celled fungus survives in ... are compromised by organ transplants or AIDS. A ... pombe appears April 22 in Molecular Cell . ... Schizosaccharomyces pombe, a model organism that,s often used to ...
... This release is available in Spanish ... U.S. Department of Agriculture (USDA) scientists and colleagues can ... disease organisms. PCR-based tests are prized tools ... and diminished markets among other economic harm. But the ...
... DETROIT A team of Wayne State University students ... participate in EcoCAR 2: Plugging in to the Future, ... Energy and General Motors. This three-year collegiate engineering program ... them the knowledge and skills needed to continue the ...
Cached Biology News:Simple fungus reveals clue to immune system protection 2New technique improves sensitivity of PCR pathogen detection 2Wayne State University chosen as Michigan's sole participant in EcoCAR 2 2
(Date:9/2/2015)... SYDNEY , Sept. 2, 2015 Australian ... won a prestigious Australian science prize recognising ,outstanding, science ... on track to globally launch a novel prostate cancer ... of a high level consortium taking out the peer-reviewed ... Interdisciplinary Scientific Research. This prize is ...
(Date:9/2/2015)... , September 2, 2015 ... BOLT) ("BioLight" or the "Company"), a firm that ... ophthalmology and cancer diagnostics, announced today that presentations ... glaucoma will be delivered at the Ophthalmology Futures ... European Society of Cataract & Refractive Surgeons ("ESCRS"), ...
(Date:9/2/2015)... ... September 02, 2015 , ... Advancing in ... surgeries. From vital sign monitoring in ICU to 3D skull printing analysis for ... make real-time clinical decisions with simultaneous access to high precision medical images and ...
(Date:9/2/2015)... ... September 02, 2015 , ... ... to creating professional commercial video content, to analysis of athletic performance. Producing ... that go by too quickly to process with the naked eye. , ...
Breaking Biology Technology:Prostate Cancer Company Minomic Wins Prestigious Eureka Science Prize 2Prostate Cancer Company Minomic Wins Prestigious Eureka Science Prize 3Presentations to Highlight BioLight's IOPtiMate[TM] System at Upcoming European Ophthalmology Conferences 2Presentations to Highlight BioLight's IOPtiMate[TM] System at Upcoming European Ophthalmology Conferences 3Surgical Workstation Powered by 6th Gen. Intel® Core™ Skylake Processors 2Surgical Workstation Powered by 6th Gen. Intel® Core™ Skylake Processors 3Fastec Introduces the Quad-HD TS5-Q High-Speed Camera 2Fastec Introduces the Quad-HD TS5-Q High-Speed Camera 3
... Chicago scientists have induced electrons in the nanocrystals of ... a smaller volume. This has the potential to improve ... "Slowing down the cooling of these electronsin this case, ... infrared laser source," said Philippe Guyot-Sionnest, Professor of Chemistry ...
... be two years away, but soccer aficionados can get ... competition when the National Institute of Standards and Technology ... nanosoccer contest next summer. , Nanosoccerthe Lilliputian competition where ... another on fields no bigger than a grain of ...
... (Nasdaq: SVNT ) today announced that Christopher,Clement, President ... corporate update at the upcoming Lazard Capital Markets 5th,Annual ... on Tuesday, November 18, 2008 at,9:25 a.m. ET. The ... in New,York City November 18-19, 2008., Individuals can ...
Cached Biology Technology:New research expected to improve laser devices and make photovoltaics more efficient 2Let the games begin! Nanosoccer at 2009 RoboCup in Austria 2Savient Pharmaceuticals to Present at the Lazard Capital Markets 5th Annual Healthcare Conference on November 18th 2
Homo sapiens postsynaptic protein CRIPT Antigen: Recombinant Protein...
... high-performance triple quadrupole 1200L sets the ... cost-conscious environment - incorporating the latest ... all liquid chromatography analytical needs. ... and the Transmission Quadrupole Analyzer provide ...
Human Legumain Affinity Purified Polyclonal Ab...
Mouse Endoglin/CD105 Fluorescein MAb (Clone 209701)...
Biology Products: