Navigation Links
Circadian rhythms: Their role and dysfunction in affective disorder
Date:8/30/2010

rt from the SCN, the body has circadian oscillators in all brain regions and peripheral tissues, for example the liver (Schulz & Steimer, 2009, Bechtold et al., 2010). The SCN is synchronised daily by environmental signals mainly light (Wirz-Justice, 2006). Receiving information on lighting conditions directly from the retina, the SCN drives secretion of the pineal gland hormone melatonin as well as and many peripheral clocks, and their outputs modulate the SCN through feedback or feed-forward effects. Thus, in the body there is a hierarchy of interacting clocks (Schulz, 2007).

In all cells, the expression of many genes changes rhythmically over 24 hours. Specific circadian genes such as CLOCK, BMAL1, and PER are responsible for the main SCN clockworking machinery as well as subsidiary clocks in other parts of the body. In mice with mutations in time-keeping genes, deviant circadian sleep-wake and other rhythms can be observed. In addition, new interest in the role of circadian dysregulation in psychiatric disorders has arisen from the finding that a mutation in a core circadian clock gene induces hyperactivity, decreased sleep, and mania-like behaviour in mice (Turek, 2008).

Animal studies were the key development that brought the field to its present exciting position, because their findings suggested that clock genes are directing the circadian rhythms in all physiological processes.

Circadian disturbances: clinical impact on affective disorders

In healthy individuals, physiological and biochemical variables such as body temperature, cortisol and melatonin, thyroid stimulating hormone (TSH), noradrenaline and serotonin exhibit a circadian rhythm. However, in patients with affective disorders, many of these circadian rhythms are disturbed in phase and amplitude (Schulz & Steimer, 2009; McClung, 2007).

For instance, women with depression have a greater degree of variability in the timing of physiological and end
'/>"/>

Contact: Sonja Mak
s.mak@update.europe.at
431-405-5734
European College of Neuropsychopharmacology
Source:Eurekalert

Page: 1 2 3 4 5 6 7 8

Related biology news :

1. Circadian clock may be critical for remembering what you learn, Stanford researchers say
2. UNC study: Tinkering with the circadian clock can suppress cancer growth
3. Two new studies on circadian rhythms
4. MicroRNAs grease the cells circadian clockwork
5. Texas A&M researchers find new mechanism for circadian rhythm
6. Light, circadian rhythms affect vast range of physiological, behavioral functions
7. Women do not recover their muscle strength as fast as men
8. Beetles get by with a little help from their friends
9. Migratory moths may hitch their rides, but theyre anything but drifters
10. IOF calls on European citizens to stand tall and speak out for their bones
11. Rare corals breed their way out of trouble
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/11/2014)... of kidney injury related to the use of hydroxyethyl ... HES molecules, according to a report in Anesthesia ... Research Society (IARS). , The "total mass of HES ... human renal proximal tubule cells (PTCs), concludes the laboratory ... Hospital Wrzburg, Austria. Other factorssuch as differences in ...
(Date:7/11/2014)... to the hippocampus, the marginal division of the ... What is the impact degree of substance P ... memory function? Yan Yu and his team, College ... using immunofluorescence staining, that substance P receptor, neurokinin ... striatal marginal division of normal rats. Unilateral or ...
(Date:7/11/2014)... Evidence exists that cannabinoid receptor type 1 ... Ca2+ influx, and reduce neurotransmitter release. However, ... 1 can increase extracellular Ca2+ influx and ... his team, Tongji Hospital Affiliated to Tongji ... Technology, China used whole cell voltage-clamp and ...
Breaking Biology News(10 mins):In lab studies, hydroxyethyl starch has direct harmful effects on kidney cells 2
... team of Australian researchers, led by University of Melbourne has ... risk of developing Autism Spectrum Disorder, ASD. Lead researcher ... at the University of Melbourne said the test could be ... "This test could assist in the early detection of the ...
... PARSONS, W. Va., September 12, 2012 Using old ... has created a glimpse of the composition of the ... and logging changed the landscape., "European Settlement-Era Vegetation of ... Forest Service scientist and her West Virginia University colleague ...
... called exons, which code for the synthesis of proteins, ... predict the different regions in a new and unannotated ... today. Now researchers at the Indian Institute of Technology ... identify DNA introns and exons an order of magnitude ...
Cached Biology News:Genetic test predicts risk for Autism 2Old deeds, witness trees offer glimpse of pre-settlement forest in West Virginia 2Old deeds, witness trees offer glimpse of pre-settlement forest in West Virginia 3
(Date:7/10/2014)... 2014 Unraveling life’s mysteries can intrigue, ... Archer Family purchased a DNA test to ... up with a lifetime of memories, sharing, and closeness. ... members’ DNA genuinely brought the family closer together. ... into genetic history and prior to taking the ...
(Date:7/10/2014)... 2014 EvoDerma ’s NOOME Anti-Aging Motion ... device now comes with a second treatment cup to help ... The new cup is thinner on the edges for a ... rough, thin and uneven surfaces on the face, neck and ... stimulating treatment on areas such as the cheeks and neck, ...
(Date:7/10/2014)... , July 10, 2014 ... Dmitry Medvedev , presented Russia,s ... BIOCAD . The Company is developing a unique ... MabNext project BIOCAD develops a number of innovative drugs ... autoimmune diseases. The ceremony took place at the International ...
(Date:7/10/2014)... -- Research and Markets ( http://www.researchandmarkets.com/research/s3bqj2/photonic ) has ... Integrated Circuit (Monolithic Integration, Hybrid Integration, Module Integration) ... their offering. http://photos.prnewswire.com/prnh/20130307/600769 ... traces its roots in the latter half of ... went unexplored and unfulfilled for several decades owing ...
Breaking Biology Technology:Ancestry DNA Test Reveals a Controversial and Undiscovered Family History 2Ancestry DNA Test Reveals a Controversial and Undiscovered Family History 3Ancestry DNA Test Reveals a Controversial and Undiscovered Family History 4Ancestry DNA Test Reveals a Controversial and Undiscovered Family History 5Introducing a New Bonus Treatment Cup for EvoDerma’s NOOME Anti-Aging Motion 2Dmitry Medvedev Presented BIOCAD the First National "Industry" Award 2International Photonic Integrated Circuit (Monolithic Integration, Hybrid Integration, Module Integration) Market - Forecasts to 2019 2
... Philadelphia Firms to Help Stimulate ... is setting the stage for future opportunity and innovation ... life science industry, Governor Edward G. Rendell said today ... that will help stimulate growth in the state,s rapidly ...
... Pharmaceuticals Inc. (Nasdaq: VNDA ) announced today ... atypical antipsychotic, Fanapt(TM) (iloperidone), at the 162nd American Psychiatric ... Fanapt(TM) is indicated for the acute treatment of schizophrenia ... on tasimelteon at APA. Tasimelteon is an investigational ...
... Spherix Incorporated (Nasdaq: SPEX ), an innovator ... technical and regulatory consulting services to food, supplement, biotechnology ... at the 2009 BIO International Conference in Atlanta, Georgia ... Obesity Control Drug" booth will showcase their ongoing global ...
Cached Biology Technology:Venture Capitalists to Invest in Promising PA Life Science Companies, Governor Rendell Says 2Vanda Pharmaceuticals to Present Data on Fanapt(TM) and Tasimelteon at the 162nd American Psychiatric Association Annual Meeting 2Vanda Pharmaceuticals to Present Data on Fanapt(TM) and Tasimelteon at the 162nd American Psychiatric Association Annual Meeting 3Vanda Pharmaceuticals to Present Data on Fanapt(TM) and Tasimelteon at the 162nd American Psychiatric Association Annual Meeting 4Spherix to Exhibit at the BIO 2009 International Convention 2
Monoclonal Mouse Anti-Human Cytokeratin 16 (48 kD)...
Sheep polyclonal to Melatonin ( Abpromise for all tested applications). Antigen: Melatonin Tg conjugate....
Rabbit polyclonal to NCoR2, prediluted ( Abpromise for all tested applications). entrezGeneID: 9612 SwissProtID: Q9Y618...
Rabbit polyclonal to TRPM8 (rating: ****) ( Abpromise for all tested applications). entrezGeneID: 79054 SwissProtID: Q3YFM7...
Biology Products: