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Circadian rhythm-metabolism link discovered
Date:7/24/2008

part of the epigenome, which consists of proteins existing in connection with a cell's DNA that take external environmental factors and make the cell's genes behave differently, even though those genes do not structurally change.

"When this balance between these two vital proteins is upset, normal cellular function can be disrupted," Sassone-Corsi said. "Because of the role these two enzymes play, changes in our sleep patterns or our diets can directly be translated into how our cells act."

The findings also suggest that proper sleep and diet could help maintain or rebuild the CLOCK-SIRT1 equilibrium and may help explain why lack of proper rest or disruption in our normal sleep patterns is known to increase hunger, which can lead to obesity and related illnesses and can accelerate the aging process.

The specific interaction between CLOCK and SIRT1 also could lead to the development of drugs aimed at facilitating healthy metabolism, thereby helping to solve major social and medical problems such as diabetes and obesity.


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Contact: Tom Vasich
tmvasich@uci.edu
949-824-6455
University of California - Irvine
Source:Eurekalert

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