Navigation Links
Circadian clock may be critical for remembering what you learn, Stanford researchers say
Date:10/8/2008

The circadian rhythm that quietly pulses inside us all, guiding our daily cycle from sleep to wakefulness and back to sleep again, may be doing much more than just that simple metronomic task, according to Stanford researchers.

Working with Siberian hamsters, biologist Norman Ruby has shown that having a functioning circadian system is critical to the hamsters' ability to remember what they have learned. Without it, he said, "They can't remember anything."

Though not known for their academic prowess, Siberian hamsters nonetheless normally develop what amounts to street smarts about their environment, as do all animals. But hamsters whose circadian system was disabled by a new technique Ruby and his colleagues developed consistently failed to demonstrate the same evidence of remembering their environment as hamsters with normally functioning circadian systems.

Until now, it has never been shown that the circadian system is crucial to learning and memory. The finding has implications for diseases that include problems with learning or memory deficits, such as Down syndrome or Alzheimer's disease. The work is described in a paper published Oct. 1 online in the early edition of the Proceedings of the National Academy of Sciences. Ruby is lead author on the paper. Siberian hamsters, also known as dwarf hamsters, are about the size of a mouse.

The change in learning retention appears to hinge on the amount of a neurochemical called GABA, which acts to inhibit brain activity. All mammal brains function according to the balance between neurochemicals that excite the brain and those that calm it. The circadian clock controls the daily cycle of sleep and wakefulness by inhibiting different parts of the brain by releasing GABA.

But if the hippocampus - the part of the brain where memories are stored - is overly inhibited, then the circuits responsible for memory storage don't function properly. "Those circuits need to be
'/>"/>

Contact: Louis Bergeron
louisb3@stanford.edu
650-725-1944
Stanford University
Source:Eurekalert

Page: 1 2 3 4

Related biology news :

1. Circadian clock controls plant growth hormone
2. Circadian rhythm-metabolism link discovered
3. New molecular clock from LLNL and CDC indicates smallpox evolved earlier than believed
4. Bioclocks work by controlling chromosome coiling
5. Web-Hosted Attendance on Demand(R) Introduces Innovative Web Time Clock
6. Systems biology approach identifies nutrient regulation of biological clock in plants
7. NYU dental professor discovers biological clock linking tooth growth to other metabolic processes
8. Molecular clock could predict risk for developing breast cancer
9. Turning back the clock for Schwann cells
10. A mammalian clock protein responds directly to light
11. Light receptors in eye play key role in setting biological clock, study shows
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/30/2014)... black truffle uses reversible epigenetic processes to regulate its ... ,methylome, - a picture of the genome regulation taking ... access journal Genome Biology and illustrates how ... and ,jumping genes,. The authors say this may shed ... controlled. , Black truffles (Tuber melanosporum), also known as ...
(Date:7/30/2014)... deep-sea octopus protected and tended her eggs until they ... July 30, 2014 in the open-access journal PLOS ... Research Institute and colleagues. , Octopuses typically have a ... protect and take care of their fertilized eggs until ... for 1 to 3 months, but little is known ...
(Date:7/30/2014)... effects of climate change on the world,s animal ... factors, according to a new paper by a ... of Queensland, and other organizations. The authors claim ... the point when it comes to climate change. ... scientists focus on the "direct" threats of changing ...
Breaking Biology News(10 mins):How black truffles deal with the jumpers in their genome 2Deep-sea octopus has longest-known egg-brooding period 2Conservation scientists asking wrong questions on climate change impacts on wildlife 2
... raise our water glasses and toast to America,s health! ... highest priorities is ensuring America has drinking water safe ... the award of $3.6 million in research grants to ... improve the detection of known and emerging drinking water ...
... CINCINNATINew research from the University of Cincinnati (UC) implicates ... (BPA)as a risk factor for metabolic syndrome and its ... fat tissues, the UC team found that BPA suppresses ... insulin sensitivity in the body and puts people at ...
... German . , Cystic kidney disease, renal ... excretory organs are characterized by overproduction or on ... renal cells. An international research team under the leadership ... now developed an animal model to better investigate these ...
Cached Biology News:To your health: EPA announces safe drinking water research 2Bisphenol A linked to metabolic syndrome in human tissue 2Gaining a better understanding of kidney diseases 2
(Date:7/31/2014)... 31, 2014 Graphite Metallizing Corporation announces ... oven carts. These bearings are uniquely suited to prevent ... bearings because of the high temperatures . , ... from the design engineers at Graphite Metallizing to overcome ... During their manufacturing operation, pans containing blocks of powder ...
(Date:7/31/2014)... Francisco, California (PRWEB) July 31, 2014 ... systems that inform therapeutic decision-making in oncology, today announced ... August 14, 2014 to discuss the Company's financial results ... provide an update about the business in the current ... audio call beginning on Thursday, August 14, 2014, at ...
(Date:7/31/2014)... July 31, 2014 Held at the ... with an overview of the disease and its treatment. ... side effects, as well as updates on the state-of-the-art ... Dr. Sandy Srinivas for organizing this educational opportunity,” says ... cancer. “Sandy and her colleagues have put together a ...
(Date:7/31/2014)... “Rapid technological advances will spread a ... unemployment, depressing American consumer spending and further shrinking ... 22—we need automated manufacturing if we are to ... economist and corporate relocation expert Dr. Ron Pollina ... States for 2014, co-published with the American Economic ...
Breaking Biology Technology:Graphite Metallizing Announces Bearings for High Temperature Oven Applications 2Graphite Metallizing Announces Bearings for High Temperature Oven Applications 3CollabRx, Inc. Schedules First Quarter Fiscal Year 2015 Financial Conference Call and Business Update 2ITRA Global Affiliate’s Pollina Corporate Top 10 Pro-Business States Minimize the Impact of Automation on Middle Class and Unemployment 2ITRA Global Affiliate’s Pollina Corporate Top 10 Pro-Business States Minimize the Impact of Automation on Middle Class and Unemployment 3ITRA Global Affiliate’s Pollina Corporate Top 10 Pro-Business States Minimize the Impact of Automation on Middle Class and Unemployment 4
... Genesis Biopharma, Inc. (OTC Bulletin Board: ... therapies, today announced that President and CEO Robert Brooke ... Investors Forum Biotech, Healthcare & Pharma Virtual Conference.  The ... 1:00 p.m. Eastern time (10:00 a.m. Pacific time) by ...
... , Researchers believe that the puzzle of catalytic gold ... reaction by first oxidising itself. New research evidence on ... us to finally understand the oxidation mechanisms of catalytic ... vital if we want to design oxidation catalysts that ...
... it will report financial results for its third quarter ended ... close of the market. The company will host ... October 21, 2010, to discuss the results.  To access the ... at least 15 minutes before the scheduled start time to ...
Cached Biology Technology:Genesis Biopharma to Present at the Informed Investors Forum Biotech, Healthcare & Pharma Virtual Conference on October 13 2Oxidation mechanisms at gold nanoclusters unraveled 2Cepheid Schedules 2010 Third Quarter Financial Results Announcement and Webcast 2
See product name for description....
Mycoplasma tested...
... Express Cloning Checker Kits provide two ... after transformation without time-consuming plasmid preparation. By ... I, all you need to do is ... bacteria directly from the transformation plates into ...
Mycoplasma tested...
Biology Products: