Navigation Links
Cilia guide neuronal migration in developing brain
Date:11/12/2012

A new study demonstrates the dynamic role cilia play in guiding the migration of neurons in the embryonic brain. Cilia are tiny hair-like structures on the surfaces of cells, but here they are acting more like radio antennae.

In developing mouse embryos, researchers were able to see cilia extending and retracting as neurons migrate. The cilia appear to be receiving signals needed for neurons to find their places.

Genetic mutations that cause the neurodevelopmental disorder Joubert syndrome interfere with these migratory functions of cilia, the researchers show. The finding suggests that problems with neuron migration may explain some aspects of Joubert syndrome patients' symptoms.

The results were published in the journal Developmental Cell.

"The most surprising thing was how dynamic the cilia are," says Tamara Caspary, PhD, assistant professor of human genetics at Emory University School of Medicine. "As interneurons migrate into the developing cerebral cortex, they move in steps. When they pause, we could see the cilia extending, as if the interneurons are trying to figure out where to go next."

The paper is the result of a collaboration between Caspary's laboratory and that of Eva Anton, PhD, professor of cell and molecular physiology at University of North Carolina School of Medicine. First author Holden Higginbotham, formerly a postdoc in Anton's laboratory, is now a faculty member at Brigham Young University in Idaho.

Readers may be familiar with motile cilia, which can be found on a paramecium or in our trachea or reproductive organs. In contrast, primary (non-motile) cilia can be found on almost every cell in the human body, each cell having just one. Ciliopathies are a class of genetic disorders involving defects in cilia, and include kidney and eye diseases as well as Joubert syndrome.

Joubert syndrome affects the development of the cerebellum and brain stem, leading to lack of mus
'/>"/>

Contact: Quinn Eastman
qeastma@emory.edu
404-727-7829
Emory University
Source:Eurekalert

Page: 1 2

Related biology news :

1. Optical waveguide connects semiconductor chips
2. DNA sequences need quality time too - guidelines for quality control published
3. A practical guide to green products and services
4. Computer scientists develop an interactive field guide app for birders
5. New analysis helps guide use of erlotinib in advanced non-small cell lung cancer
6. Lower dosage CT-guided lung biopsy protocol maintains quality, minimizes exposure
7. Canadian Journal of Cardiology publishes new atrial fibrillation guidelines
8. UC research tests new tool to guide reintroduction of the American chestnut
9. Newly released FDA draft guidelines for biosimilar drugs to be discussed at conference
10. EU FET program funds research on 3D neuronal structures mimicking human brain tissue
11. Ion selectivity in neuronal signaling channels evolved twice in animals
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/31/2015)... Conn. , Jul. 31, 2015 NXT-ID, Inc. ... biometric authentication company focused on the growing mobile commerce ... that it has filed provisional patent 62/198989 for ... This invention highlights a method to advance crypto-currencies such ... by introducing a common, uniform way to manage all ...
(Date:7/27/2015)... , July 27, 2015  Synaptics Inc. ... human interface solutions, today announced that Huawei has ... touchscreen solution for its stylish smartwatch. Huawei chose ... proven reliability, low power and highly responsive human ... finger. Huawei designers also required a classic round ...
(Date:7/23/2015)... -- Research and Markets ( http://www.researchandmarkets.com/research/rzzp3v/global_outlook_of ) has ... of the Biometrics Industry 2015 " report ... biometrics market is likely to witness significant growth ... the uptake of multiple technologies available. The year ... growth of biometrics in existing applications as well ...
Breaking Biology News(10 mins):NXT-ID Patents Electronic Crypto-Currency Management Technology 2NXT-ID Patents Electronic Crypto-Currency Management Technology 3NXT-ID Patents Electronic Crypto-Currency Management Technology 4Synaptics Touchscreen Solution Powers New Huawei Watch 2Synaptics Touchscreen Solution Powers New Huawei Watch 3Global Outlook of the Biometrics Industry 2015 2Global Outlook of the Biometrics Industry 2015 3
... Khalid Iqbal Lifetime Achievement Award" for its role as ... disease. The award ceremony was held yesterday (10:45 am ... International Conference (AAIC 2013)" in Boston (USA). Eva-Maria ... progress in Alzheimer,s research in the course of their ...
... avian H7N9 influenza that emerged in China this year have ... the infection, but testing for antiviral resistance can give misleading ... The authors of a study published in mBio , ... characterized viruses taken from the first person known to be ...
... -- United Medical Education, a leading online certifying institution ... Pediatric Advanced Life Support (PALS), and Basic Life Support ... course materials for its ACLS online renewal ... online courses. (Photo: http://photos.prnewswire.com/prnh/20130715/MN47087 ) ...
Cached Biology News:Pioneers in Alzheimer's research: Research couple honored for its lifetime achievement 2Pioneers in Alzheimer's research: Research couple honored for its lifetime achievement 3H7N9 influenza strain resistant to antivirals, but tests fail to identify resistance 2H7N9 influenza strain resistant to antivirals, but tests fail to identify resistance 3ACLS Online Renewal Course from United Medical Education Now Features Newly-Updated Course Materials 2
(Date:7/31/2015)... , ... July 31, 2015 , ... ... competitive market analysis and premium industry insights on the global resorcinol industry. The ... a collective study of vivid market scenarios and analysis of primary and secondary ...
(Date:7/30/2015)... July 30, 2015 AACC welcomed thousands ... 2015 AACC Annual Meeting & Clinical Lab Expo ... 26–30. The meeting showcased revolutionary advancements in clinical ... of healthcare providers to diagnose patients quickly and ... treatment. As of Wednesday, July ...
(Date:7/30/2015)... 2015 According to a new ... Modeling, PB/PK, PKPD, Trial Design, Toxicity Prediction, In-house, Contract ... Trial), by End Users - Global Forecast to 2020", ... reach USD 2,107.99 million by 2020 from USD 1,034.93 ... Browse more than 75 ...
(Date:7/30/2015)... customers across the globe, ISN improves the efficiency and effectiveness of contractor management systems. ... and reliable contractors in over 80 countries. ... ... Over 60,000 Worldwide Customers In More Than 80 Countries ... Headquartered in Dallas, TX , ISN has additional offices in ...
Breaking Biology Technology:Resorcinol Market to Grow at 6% CAGR to 2019 Says New Research Report at ReportsnReports.com 2Resorcinol Market to Grow at 6% CAGR to 2019 Says New Research Report at ReportsnReports.com 3Resorcinol Market to Grow at 6% CAGR to 2019 Says New Research Report at ReportsnReports.com 4Innovative Research on Cancer, Heart Disease, and Infectious Diseases Draws More than 17,500 Attendees to 2015 AACC Annual Meeting 2Innovative Research on Cancer, Heart Disease, and Infectious Diseases Draws More than 17,500 Attendees to 2015 AACC Annual Meeting 3Innovative Research on Cancer, Heart Disease, and Infectious Diseases Draws More than 17,500 Attendees to 2015 AACC Annual Meeting 4Biosimulation Market Worth 2,107.99 Million USD by 2020 2Biosimulation Market Worth 2,107.99 Million USD by 2020 3Biosimulation Market Worth 2,107.99 Million USD by 2020 4ISN Reaches Over 60,000 Worldwide Customers 2ISN Reaches Over 60,000 Worldwide Customers 3
... RICHMOND, Va., June 30 Insmed Inc. (Nasdaq: ... been added to the Russell 3000 Index following Russell Investments, ... indexes on June 26, 2009. Insmed was also added ... of Russell,s U.S. indexes captures the 4,000 largest U.S. stocks ...
... ... of a comprehensive global report on Prescription Drugs market. The global ... factors slowing down growth in the global prescription drugs market include ... of generics, falling drug costs, and fewer new drug approvals. On ...
... (Nasdaq: BSTC ), a biopharmaceutical company developing first ... to the Russell 3000 and Russell 2000 Indexes effective at ... The Russell family of U.S. indexes is reconstituted annually and ... U.S. equity market. , , The Russell 3000 Index ...
Cached Biology Technology:Insmed Announces Addition to the Russell 3000(R) Index 2Global Prescription Drugs Market to Cross $897 Billion by 2015, According to New Report by Global Industry Analysts, Inc. 2Global Prescription Drugs Market to Cross $897 Billion by 2015, According to New Report by Global Industry Analysts, Inc. 3Global Prescription Drugs Market to Cross $897 Billion by 2015, According to New Report by Global Industry Analysts, Inc. 4BioSpecifics Technologies Corp. Added to Russell 3000 and Russell 2000 Indexes 2
... silencing experiments often call for critical, ... Transfection Agent refines siRNA transfection protocols ... lipid-based formulation can be used to ... are subcultured without increased cytotoxicity. ...
... The CHEMICON® CaspaTag™ Pan-Caspase In Situ ... detection of active caspases in cells undergoing ... only. Not for use in diagnostic or ... Assay Kits use a novel approach to ...
... INTERFERin is a new-generation siRNA transfection ... efficiency at 1 nM siRNA in a ... with excellent cell viability. Using low siRNA ... effects observed when transfecting siRNA at higher ...
... Cell and Tissue Staining Kits are intended ... range of histological and cytological specimens. These ... antibodies manufactured by either R&D Systems or ... on the formation of the Avidin-Biotin Complex ...
Biology Products: