Navigation Links
Cilia guide neuronal migration in developing brain
Date:11/12/2012

A new study demonstrates the dynamic role cilia play in guiding the migration of neurons in the embryonic brain. Cilia are tiny hair-like structures on the surfaces of cells, but here they are acting more like radio antennae.

In developing mouse embryos, researchers were able to see cilia extending and retracting as neurons migrate. The cilia appear to be receiving signals needed for neurons to find their places.

Genetic mutations that cause the neurodevelopmental disorder Joubert syndrome interfere with these migratory functions of cilia, the researchers show. The finding suggests that problems with neuron migration may explain some aspects of Joubert syndrome patients' symptoms.

The results were published in the journal Developmental Cell.

"The most surprising thing was how dynamic the cilia are," says Tamara Caspary, PhD, assistant professor of human genetics at Emory University School of Medicine. "As interneurons migrate into the developing cerebral cortex, they move in steps. When they pause, we could see the cilia extending, as if the interneurons are trying to figure out where to go next."

The paper is the result of a collaboration between Caspary's laboratory and that of Eva Anton, PhD, professor of cell and molecular physiology at University of North Carolina School of Medicine. First author Holden Higginbotham, formerly a postdoc in Anton's laboratory, is now a faculty member at Brigham Young University in Idaho.

Readers may be familiar with motile cilia, which can be found on a paramecium or in our trachea or reproductive organs. In contrast, primary (non-motile) cilia can be found on almost every cell in the human body, each cell having just one. Ciliopathies are a class of genetic disorders involving defects in cilia, and include kidney and eye diseases as well as Joubert syndrome.

Joubert syndrome affects the development of the cerebellum and brain stem, leading to lack of mus
'/>"/>

Contact: Quinn Eastman
qeastma@emory.edu
404-727-7829
Emory University
Source:Eurekalert

Page: 1 2

Related biology news :

1. Optical waveguide connects semiconductor chips
2. DNA sequences need quality time too - guidelines for quality control published
3. A practical guide to green products and services
4. Computer scientists develop an interactive field guide app for birders
5. New analysis helps guide use of erlotinib in advanced non-small cell lung cancer
6. Lower dosage CT-guided lung biopsy protocol maintains quality, minimizes exposure
7. Canadian Journal of Cardiology publishes new atrial fibrillation guidelines
8. UC research tests new tool to guide reintroduction of the American chestnut
9. Newly released FDA draft guidelines for biosimilar drugs to be discussed at conference
10. EU FET program funds research on 3D neuronal structures mimicking human brain tissue
11. Ion selectivity in neuronal signaling channels evolved twice in animals
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/1/2014)... Case Western Reserve University researchers hope to take a ... for an aggressive form of breast cancer in leafy ... about administering the vaccine either by eating the salad ... Nicole Steinmetz, assistant professor of biomedical engineering at Case ... project. , The Susan G. Komen breast cancer organization ...
(Date:10/1/2014)... rainforests, prairies and forests of the world can also ... according to a surprising new study led by Colorado ... , The research team analyzed 596 soil samples collected ... stunning diversity of below-ground life, most of which had ... to 16.2 percent of the organisms discovered in the ...
(Date:9/30/2014)... the University of California, San Diego, have completed the ... a method that uses the pixels in an image ... as mesh-free simulation. , The researchers, led by J.S. ... the Jacobs School of Engineering at UC San Diego, ... at the CompIMAGE,14 conference in Pittsburgh this month. Chen ...
Breaking Biology News(10 mins):Scientists wield plant viruses against deadly human disease 2Scientists wield plant viruses against deadly human disease 3Microbes in Central Park soil: If they can make it there, they can make it anywhere 2Microbes in Central Park soil: If they can make it there, they can make it anywhere 3First comprehensive meshfree numerical simulation of skeletal muscle tissue achieved 2
... Ocean explorers are puzzling out Nature,s purpose behind an astonishing ... - each perhaps a ticket-holder in life,s lottery, awaiting conditions ... The inventory and study of the hardest-to-see sea species -- ... which together underpin almost all other life on Earth -- ...
... implant that essentially melts into place, snugly fitting to the ... better devices to monitor and control seizures, and to transmit ... cord. "These implants have the potential to maximize the ... the brain. They could provide a platform for a ...
... in six will get prostate cancer during his lifetime, making ... a new partnership with Areva Med, UC researchers will investigate ... of prostate cancer tumors. In the study, UC researchers ... efficacy of a new agent targeted against a specific protein ...
Cached Biology News:Explorers census hard-to-see sea life: microbes, tiny animals key to Earth's food, carbon systems 2Explorers census hard-to-see sea life: microbes, tiny animals key to Earth's food, carbon systems 3Explorers census hard-to-see sea life: microbes, tiny animals key to Earth's food, carbon systems 4Explorers census hard-to-see sea life: microbes, tiny animals key to Earth's food, carbon systems 5Explorers census hard-to-see sea life: microbes, tiny animals key to Earth's food, carbon systems 6Explorers census hard-to-see sea life: microbes, tiny animals key to Earth's food, carbon systems 7Explorers census hard-to-see sea life: microbes, tiny animals key to Earth's food, carbon systems 8Explorers census hard-to-see sea life: microbes, tiny animals key to Earth's food, carbon systems 9Explorers census hard-to-see sea life: microbes, tiny animals key to Earth's food, carbon systems 10A brain-recording device that melts into place 2A brain-recording device that melts into place 3UC to test targeted treatment for prostate cancer 2
(Date:9/30/2014)... German . , ... in a semiconductor layer. Quantum dots are small structures that ... a short laser pulse is fired at the photonic crystal, ... a change in the electromagnetic field around it. This change ... by the dot. As soon as the refractive index recovers ...
(Date:9/30/2014)... Sept. 30, 2014 Report Details ... highest potential revenues Do you want to find ... you revenue predictions for those biological drugs from ... you find financial data, R&D trends, opportunities and ... sales forecasts to 2024 at overall world market, ...
(Date:9/30/2014)... (PRWEB) September 30, 2014 Follow ... level of each type of cholesterol carrier or lipoprotein ... presence of excessive cholesterol levels in the body, especially ... condition to heart attack and other cardiovascular disorders. Cardiovascular ... therefore testing for cholesterol levels on a regular basis, ...
(Date:9/30/2014)... OriginOil Inc. (OTC/QB: OOIL), developer of ... clean up large quantities of water, announced today that ... on the launch of the company's CLEAN-FRACâ„¢ industrial grade ... partner STW Resources . , Immediately upon startup, ... (bpd) and achieved a 99.8% reduction in Turbidity on ...
Breaking Biology Technology:Ultrafast remote switching of light emission 2Biosimilars and Follow-On Biologics: World Industry and Market Prospects 2014-2024 2Biosimilars and Follow-On Biologics: World Industry and Market Prospects 2014-2024 3Biosimilars and Follow-On Biologics: World Industry and Market Prospects 2014-2024 4Biosimilars and Follow-On Biologics: World Industry and Market Prospects 2014-2024 5Surging Diabetic, Obese and Hypertensive Population Drives the Global Cholesterol Testing Market, According to New Report by Global Industry Analysts, Inc. 2Surging Diabetic, Obese and Hypertensive Population Drives the Global Cholesterol Testing Market, According to New Report by Global Industry Analysts, Inc. 3Surging Diabetic, Obese and Hypertensive Population Drives the Global Cholesterol Testing Market, According to New Report by Global Industry Analysts, Inc. 4OriginOil, Inc. Report to Shareholders: Blue Gold in West Texas 2
... and Chemicon International, Inc. announced today ... and apply Madison-based Promegas DNA-directed, RNA interference (ddRNAi) ... division of Serologicals Corporation, will have the right ... ddRNAi-based products and reagents for life science research. ...
... so much media attention focused on the effects of ... some light on the issue. Whatever the product, there ... cheaper labor. The effects of this are hurting many ... matter what you are making, whether you manufacture low- ...
... is reducing surgery delays and controlling instrument and staff ... and trays by using a new surgical instrument management ... , ,Gundersen Lutheran operates a teaching hospital with 325 ... medical practices, community clinics, eye clinics and pharmacies. It ...
Cached Biology Technology:Offshore outsourcing affects American workers 2Offshore outsourcing affects American workers 3Gunderson Lutheran Implements Instrument Management Systems 2
...
... and flexibility of the BDTM LSR, the first UV ... The BD LSR II has performance, capabilities, and ... Free up your high-performance cell sorter by moving your ... LSR II. The BD LSR II can be configured ...
... Flow Cytometer System is a full featured, two ... the C6 Flow Cytometer, CFlow Software, and a ... Cytometer System provides all the capabilities of the ... the price. The C6 Flow Cytometer System has ...
...
Biology Products: