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Cilia: small organelles, big decisions
Date:10/3/2007

rrors seen in the fish pointed to an imbalance where canonical signaling predominated.

A series of biochemical studies revealed that cilia normally help a cell keep the right balance by selectively destroying proteins in the canonical branch to prevent excess growth. Defective ciliary function therefore leads to defective destruction of key proteins, which then causes problems in interpreting the Wnt signal.

We thought that the key to the balancing act occurred inside the cell, but it now seems clear that the cilia are the main relay stations, Katsanis says. Weve just reset a huge volume of literature under a new light.


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Contact: Nick Zagorski
rs1@jhmi.edu
443-287-2251
Johns Hopkins Medical Institutions
Source:Eurekalert

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