Navigation Links
Cilia: small organelles, big decisions
Date:10/3/2007

Johns Hopkins researchers say they have figured out how human and all animal cells tune in to a key signal, one that literally transmits the instructions that shape their final bodies. It turns out the cells assemble their own little radio antenna on their surfaces to help them relay the proper signal to the developmental proteins listening on the inside of the cell.

The transmitters are primary cilia, relatively rigid, hairlike tails that respond to specialized signals from a host of proteins, including a key family of proteins known as Wnts. The Wnts in turn trigger a cascade of shape-making decisions that guide cells to take specific shapes, like curved eyelid cells or vibrating hair cells in the ear, and even make sure that arms and legs emerge at the right spots.

Our experiments go to the heart of the development and maintenance of our body tissue, says Johns Hopkins geneticist Nicholas Katsanis, Ph.D., associate professor at the McKusick-Nathans Institute for Genetic Medicine. Any miscues with the Wnt signaling pathway, says Katsanis, and youre looking at major childhood diseases and defects.

In a report published on September 30 in Nature Genetics, Katsanis and his team used a small transparent fish, zebrafish, to literally watch what happened if they chemically blocked the production of three proteins that are required for primary cilia function during the period when a fish egg develops into a grown up, fully-finned fish.

The more they blocked, the more developmental errors - for example, the growing fish would not properly extend their tails - they were able to track to defective Wnt signaling.

Katsanis notes that once inside a cell, the Wnt pathway splits into two branches that need to be balanced depending on the needs of each cell: the so-called canonical branch, which typically drives cells to multiply, and the non-canonical branch, which controls messages to refine cell shape and growth. The e
'/>"/>

Contact: Nick Zagorski
rs1@jhmi.edu
443-287-2251
Johns Hopkins Medical Institutions
Source:Eurekalert

Page: 1 2

Related biology news :

1. Stopping smallpox in its tracks: A new anti-viral approach
2. Small species back-up giant marsupial climate change extinction claim
3. New World founders small in number
4. Secret of smallpoxs success may lead to bioterror cure
5. Circulating stem cells play small role in lung repair
6. Small worm yields big clue on muscle receptor action
7. No small feat: First ever gene therapy success for muscular dystrophy achieved
8. LIAI scientists make major finding on potential smallpox treatment
9. Researchers develop new testing methods for potential monkeypox or smallpox outbreak
10. Solexa and collaborating scientists illuminate the small RNA component of the transcriptome
11. Delaware scientists make significant advance in study of small RNAs
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/20/2015)... Mar. 20, 2015 Research and Markets ... of the "India Sensors Market Forecast and ... The sensor market is projected to grow ... Consumer electronics, automotive, industrial and healthcare sectors ... the country. In addition, adoption of MEMS technology ...
(Date:3/20/2015)... , March 20, 2015 NXT-ID, Inc. ... biometric authentication company focused on the growing mobile commerce ... wallet is one of the products featured in 2015 ... 20th at 11:00 PM EST on the DIY Network. ... Las Vegas , site of the ...
(Date:3/19/2015)...  NXT-ID, Inc. (NASDAQ: NXTD ) ("NXT-ID" or ... mobile commerce market, announces its biometric payment technology, the Wocket® ... this week on Washington DC,s Fox ... segment "The Next Great Thing", host Laura Evans ... and ,a really big breakthrough in mobile payment.,  ...
Breaking Biology News(10 mins):India Sensors Market Forecast and Opportunities 2020 - STMicroelectronics held the largest share in 2014 2India Sensors Market Forecast and Opportunities 2020 - STMicroelectronics held the largest share in 2014 3NXT-ID's Wocket Biometric Smart Wallet to Air on "I Want That" International CES Special 2NXT-ID's Wocket Biometric Smart Wallet to Air on "I Want That" International CES Special 3NXT-ID's Wocket Smart Wallet Featured on Fox News Segment, "The Next Great Thing" 2NXT-ID's Wocket Smart Wallet Featured on Fox News Segment, "The Next Great Thing" 3
... 2010) -- A cell devotes a significant amount of ... sorts of chromosomal rearrangements characteristic of many cancers. Assays ... needed in order to understand the individual genes and the ... issue of Cold Spring Harbor Protocols , ...
... developed by Laszlo Otvos, a research professor of ... looks to be a highly-effective therapy against infections ... Otvos and his collaborators found that when ... than current antimicrobial chemotherapy measures in treating multidrug-resistant ...
... Park, MD (August 31, 2010) -- A new imaging ... of the eyeball (ocular fundus) may pave the way ... of the eye, such as age-related macular degeneration and ... Review of Scientific Instruments, which is published ...
Cached Biology News:Cold Spring Harbor Protocols features chromosomal rearrangement, gene copy number methods 2LEDs illuminate eye for ocular disease screening 2
(Date:4/21/2015)... and RESEARCH TRIANGLE PARK, N.C. ... (NASDAQ: UTHR ) announced today that it will ... open on Tuesday, April 28, 2015. United ... 28, 2015, at 9:00 a.m. Eastern Time.  The teleconference ... 1-970-315-0533.  A rebroadcast of the teleconference will be available ...
(Date:4/21/2015)... April 21, 2015 Whether it’s used for ... or bolted to a Kessler CineDrive in a ... the beach, the TS3-H is designed to help any shooter ... brand-new state-of-the-art 5MP sensor, the TS5-H offers the same convenient ... imaging characteristics. , According to Tom Boldt for Fastec, ...
(Date:4/20/2015)... Winston-Salem, NC and Champaign, IL (PRWEB) April 20, 2015 ... announced today the establishment of its 12th clinical research ... 2015, PMG Research has assumed operation of the clinical ... IL, expanding PMG’s footprint outside the Southeast to a ... site within a 150 multi-specialty physician practice enhances PMG’s ...
(Date:4/20/2015)... , April 20, 2015  Eli Lilly and Company ... from several targeted cancer therapies, reflecting Lilly,s diverse oncology ... Annual Meeting 2015, held April 18-22 in ... Discoveries to Patients" is the theme of this year,s ... commitment to broadening its portfolio of therapies that accelerate ...
Breaking Biology Technology:Fastec Imaging Releases the TS5-H High Definition High-Speed Camera 2Fastec Imaging Releases the TS5-H High Definition High-Speed Camera 3PMG Research Announces the Formation of its 12th Site in Champaign-Urbana, IL 2PMG Research Announces the Formation of its 12th Site in Champaign-Urbana, IL 3Lilly Releases Early-Stage Pipeline Data at AACR Annual Meeting 2015 2Lilly Releases Early-Stage Pipeline Data at AACR Annual Meeting 2015 3Lilly Releases Early-Stage Pipeline Data at AACR Annual Meeting 2015 4Lilly Releases Early-Stage Pipeline Data at AACR Annual Meeting 2015 5Lilly Releases Early-Stage Pipeline Data at AACR Annual Meeting 2015 6
... 10 /Xinhua-PRNewswire/ -- WuXi PharmaTech (NYSE:,WX), a leading pharmaceutical, ... operations in China and the United,States, today announced that ... Most,Innovative Enterprises" and its CEO Dr. Ge Li was ... Chinese Enterprises" at the 8th China,Enterprise Innovation Forum held ...
... access to 'Best Practices for Long-term Jatropha ... Rajagopal's highly successful November 2007 position paper ... is being offered. It emphasizes the need ... it nears commercialization as a viable alternative ...
... Australia, July 10 Cytopia (ASX: CYT),announced today ... Scientific,Advisor to the company., Based in California, ... executive management team, on a part-time basis during ... has held global,leadership roles at Glaxo Wellcome and ...
Cached Biology Technology:WuXi PharmaTech (NYSE: WX) Named the Most Innovative Company in China and CEO Dr. Li the Most Innovative Leader of Chinese Enterprises 2Comprehensive Jatropha Standards Mandatory in Optimum Long-term Biofuel Efficacy 2Comprehensive Jatropha Standards Mandatory in Optimum Long-term Biofuel Efficacy 3Comprehensive Jatropha Standards Mandatory in Optimum Long-term Biofuel Efficacy 4Cytopia Strengthens Scientific Team With US-Based Drug Development Specialist 2
... This antibody is specific for human cardiac troponin ... the Ca-binding signals responsible for contraction of cardiac ... troponin complex in human cells. It also cross-reacts ... Antigen: Highly purified human ...
...
Troponin I Immunogen: Full length native protein (purified) (Human). Storage: -20 C, Avoid Freeze/Thaw Cycles...
Anti-SDF-1β/PBSF affinity isolated antibody lyophilized powder Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline recombinant human SDF-1β/PBSF expressed in E....
Biology Products: