Navigation Links
Cigarette smoke impacts genes linked to health of heart and lungs
Date:7/10/2013

New insights into why obese cigarette smokers experience a high risk of heart disease suggest that cigarette smoke affects the activity of hundreds of key genes that both protect the heart and lungs and expose them to damage. The study, published in ACS' Chemical Research in Toxicology, suggests that the effects may be especially profound in obese nonsmokers who inhale "sidesteam smoke" from cigarettes smoldering nearby.

Diana J. Bigelow and colleagues point out that active smoking doubles the risk of heart disease, while second-hand smoke exposure increases this risk by about one-third. They set out to gain more information on why the risks are especially high among people with obesity, using specially fed laboratory mice that are stand-ins for humans in such experiments.

The report describes how mainstream smoke and to a greater extent, sidestream smoke, inhibit the activity of genes that protect the heart and lungs, and activate genes associated with an increased risk of heart disease. Those changes were more profound in obese mice than normal-weight mice. "The present study is the first, to our knowledge, that addresses the in vivo transcriptional response of the heart to cigarette smoke exposure in the setting of high fat diet and obesity, and thus takes a first step toward identifying the molecular basis of adaptive responses that may lead to an increased risk of heart disease in obese smokers," the report states.


'/>"/>

Contact: Michael Bernstein
m_bernstein@acs.org
202-872-6042
American Chemical Society
Source:Eurekalert

Page: 1

Related biology news :

1. Continued research needed on treatment for women with lung cancer who are never smokers
2. Satellite animation shows smoke from Californias Springs fire
3. Short daily walk might help teen smokers cut down or quit, new study says
4. Scientists create new tools for battling secondhand smoke
5. Dartmouth researchers invent real time secondhand smoke sensor
6. International study: Where theres smoke or smog, theres climate change
7. Second-hand smoke increases risk of invasive meningococcal disease in children
8. Rapid response in cases of smoke poisoning
9. Scripps research scientists find anticonvulsant drug helps marijuana smokers kick the habit
10. Meeting: Experts Convene to Examine Impacts of Fukushima on the Ocean
11. Understanding Earth processes and human impacts, plus another look at Mars
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/9/2016)... Fla. , March 9, 2016  Crossmatch ... authentication and enrollment solutions, today announced the addition ... ® Altus multi-factor authentication platform. New ... InfoSec managers to step-up security where it,s needed ... Washington, DC . --> ...
(Date:3/3/2016)... SOTO, Kansas , March 3, 2016 ... Oncimmune,s Early CDT®-Lung, a blood test to aid ... cancer Early CDT®-Lung test to its clients ... Early CDT®-Lung test to its clients which include ... a leader in early cancer detection, today announced a ...
(Date:3/1/2016)...  (RSAC Booth #3041) – True fraud costs business ... is lost to false positives, where good customers are ... At the RSA Conference 2016, NuData Security is calling for ... by devaluing the data fraudsters have in abundance in ... --> --> Cheap and readily ...
Breaking Biology News(10 mins):
(Date:4/27/2016)... , ... April 27, 2016 , ... Cambridge Semantics, ... semantic web technology, today announced that it has been named to The Silicon Review’s ... financial services and other markets, Cambridge Semantics serves the needs of end users facing ...
(Date:4/27/2016)... ... 2016 , ... The Pittcon Organizing Committee is pleased to announce that Charles ... member of Committee since 1987. Since then, he has served in a number of ... chairman for both the program and exposition committees. In his professional career, Dr. Gardner ...
(Date:4/27/2016)... VANCOUVER, British Columbia , April 27, 2016 ... "Gesellschaft" oder "NanoStruck") (CSE: NSK) (OTCPink: NSKQB) ( ... sie im Anschluss an ihre Pressemitteilung vom 13. ... Inc. erhalten hat, ihre Finanzen um zusätzliche 200.000.000 ... auf 4.000.000 Kanadische Dollar zu bringen. Davon wurden ...
(Date:4/27/2016)... , ... April 27, 2016 , ... ... is pleased to announce the appointment of John Tilton as Chief Commercial Officer.  ... Director and one of the founding commercial leaders responsible for the commercialization of ...
Breaking Biology Technology: