Navigation Links
Cigarette smoke, alcohol damage hearts worse as combo
Date:11/21/2007

BIRMINGHAM, Ala. Tobacco smoke-filled air is bad for cardiovascular health, and drinking alcohol at the same time only makes it worse, according to researchers at the University of Alabama at Birmingham (UAB).

Testing the theory that moderate alcohol consumption provides some heart-protection benefits, the UAB team said it wanted to take the idea further and look at the effects of smoking and breathing second-hand smoke along with drinking.

They reported that mice exposed to smoky air in a laboratory enclosure and fed a liquid diet containing ethanol, the intoxicating ingredient in alcohol, had a 4.7-fold increase in artery lesions. That compares to mice who breathed filtered air and ate a normal solid diet.

Artery lesions are a common problem in heavy smokers and a key sign of advancing cardiovascular disease. The results are published in the journal Free Radical Biology & Medicine.

The researchers reported mice solely exposed to the smoky air had a 2.3-fold increase in artery lesions when compared to mice who breathed filtered air. Mice solely fed a liquid diet containing ethanol had a 3.5-fold increase in artery lesions when compared to mice fed a normal diet.

The study points to a greater need to understand the negative biological impact of single or multiple risky behaviors, and the compounding effect of environmental hazards such as second-hand smoke, said Scott Ballinger, Ph.D., an associate professor in the UAB Department of Pathology and lead author on the study.

Our study shows that exposure to cigarette smoke when combined with alcohol consumption caused the greatest degree of cardiovascular disease development compared to either action or exposure alone, Ballinger said.

Because moderate alcohol consumption is commonly thought to be cardioprotective, these findings are important for smokers and non-smokers alike in terms of what you should and should not do to protect their health, said Shannon Bailey, Ph.D., an associate professor in the UAB Department of Environmental Health Sciences and a co-investigator on the study.

The mice experiments were performed over a five-week period. Blood-alcohol concentrations reached the equivalent of a 150-pound adult consuming 2 drinks per hour. Cigarette smoke exposure was similar to being in an automobile with a chain smoker with the windows closed.

In addition to measuring artery lesions in the study mice, the UAB team looked at other signs of advancing cardiovascular disease like DNA damage and oxidative stress in key heart tissues.

Like the artery lesions, these added measurements showed that taking in both smoky air and ethanol had the effect of basically nullifying any potential heart benefit from drinking alcohol by itself.


'/>"/>

Contact: Troy Goodman
tdgoodman@uab.edu
205-934-8938
University of Alabama at Birmingham
Source:Eurekalert

Related biology news :

1. Cigarette smoking may accelerate disability in those with MS
2. Does the desire to consume alcohol and tobacco come from our genetic makeup?
3. Study shows link between alcohol consumption and hiv disease progression
4. Study reveals possible genetic risk for fetal alcohol disorders
5. Alcohol and sleep restriction can affect young mens alertness and driving performance
6. Extended wakefulness, combined with alcohol, severely impairs driving performance
7. Human derived stem cells can repair rat hearts damaged by heart attack
8. Enzyme alerts cells powerful army to repair DNA damage
9. Simulation reveals how body repairs balance after damage
10. Mixing large doses of both acetaminophen painkiller and caffeine may increase risk of liver damage
11. MIT: Human-generated ozone will damage crops
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/13/2016)... CHICAGO , April 13, 2016  IMPOWER physicians ... are setting a new clinical standard in telehealth ... By leveraging the higi platform, IMPOWER patients can ... weight, pulse and body mass index, and, when they ... quick and convenient visit to a local retail location ...
(Date:3/31/2016)... 31, 2016  Genomics firm Nabsys has completed a ... Barrett Bready , M.D., who returned to the company ... technical leadership team, including Chief Technology Officer, John ... Steve Nurnberg and Vice President of Software and Informatics, ... Dr. Bready served as CEO of Nabsys ...
(Date:3/23/2016)... March 23, 2016 ... Sicherheit Gesichts- und Stimmerkennung mit Passwörtern ... (NASDAQ: MESG ), ein führender Anbieter ... Unternehmen mit SpeechPro zusammenarbeitet, um erstmals dessen ... wird die Möglichkeit angeboten, im Rahmen mobiler ...
Breaking Biology News(10 mins):
(Date:4/27/2016)... ... 2016 , ... A compact PET scanner called NuPET™ has ... Resonance Imaging) in existing third-party MRI systems. PET and MRI are complementary imaging ... Simultaneous PET/MRI imaging offers a solution to many challenges that face researchers who ...
(Date:4/27/2016)... 27, 2016 ReportsnReports.com adds ... specific focus on US, EU, China ... to the healthcare business intelligence collection of its ... Complete report on the Flow Cytometry market spread ... with 282 tables and figures is now available ...
(Date:4/26/2016)... ... 2016 , ... Heidelberg Instruments, a leader in design, development ... Volume Pattern Generator (VPG) line of lithography systems. The breakthrough VPG+ system is ... a solution for mid volume direct write lithography applications. It utilizes the ...
(Date:4/26/2016)... ... April 26, 2016 , ... ... of a significant operating grant from 1Plus12 Corporation. The grant will be used ... activities as outlined on the organization's website http://www.ivsci.org , In accounting ...
Breaking Biology Technology: