Navigation Links
Cigarette smoke, alcohol damage hearts worse as combo
Date:11/21/2007

BIRMINGHAM, Ala. Tobacco smoke-filled air is bad for cardiovascular health, and drinking alcohol at the same time only makes it worse, according to researchers at the University of Alabama at Birmingham (UAB).

Testing the theory that moderate alcohol consumption provides some heart-protection benefits, the UAB team said it wanted to take the idea further and look at the effects of smoking and breathing second-hand smoke along with drinking.

They reported that mice exposed to smoky air in a laboratory enclosure and fed a liquid diet containing ethanol, the intoxicating ingredient in alcohol, had a 4.7-fold increase in artery lesions. That compares to mice who breathed filtered air and ate a normal solid diet.

Artery lesions are a common problem in heavy smokers and a key sign of advancing cardiovascular disease. The results are published in the journal Free Radical Biology & Medicine.

The researchers reported mice solely exposed to the smoky air had a 2.3-fold increase in artery lesions when compared to mice who breathed filtered air. Mice solely fed a liquid diet containing ethanol had a 3.5-fold increase in artery lesions when compared to mice fed a normal diet.

The study points to a greater need to understand the negative biological impact of single or multiple risky behaviors, and the compounding effect of environmental hazards such as second-hand smoke, said Scott Ballinger, Ph.D., an associate professor in the UAB Department of Pathology and lead author on the study.

Our study shows that exposure to cigarette smoke when combined with alcohol consumption caused the greatest degree of cardiovascular disease development compared to either action or exposure alone, Ballinger said.

Because moderate alcohol consumption is commonly thought to be cardioprotective, these findings are important for smokers and non-smokers alike in terms of what you should and should not do to protect their health, said Shannon Bailey, Ph.D., an associate professor in the UAB Department of Environmental Health Sciences and a co-investigator on the study.

The mice experiments were performed over a five-week period. Blood-alcohol concentrations reached the equivalent of a 150-pound adult consuming 2 drinks per hour. Cigarette smoke exposure was similar to being in an automobile with a chain smoker with the windows closed.

In addition to measuring artery lesions in the study mice, the UAB team looked at other signs of advancing cardiovascular disease like DNA damage and oxidative stress in key heart tissues.

Like the artery lesions, these added measurements showed that taking in both smoky air and ethanol had the effect of basically nullifying any potential heart benefit from drinking alcohol by itself.


'/>"/>

Contact: Troy Goodman
tdgoodman@uab.edu
205-934-8938
University of Alabama at Birmingham
Source:Eurekalert

Related biology news :

1. Cigarette smoking may accelerate disability in those with MS
2. Does the desire to consume alcohol and tobacco come from our genetic makeup?
3. Study shows link between alcohol consumption and hiv disease progression
4. Study reveals possible genetic risk for fetal alcohol disorders
5. Alcohol and sleep restriction can affect young mens alertness and driving performance
6. Extended wakefulness, combined with alcohol, severely impairs driving performance
7. Human derived stem cells can repair rat hearts damaged by heart attack
8. Enzyme alerts cells powerful army to repair DNA damage
9. Simulation reveals how body repairs balance after damage
10. Mixing large doses of both acetaminophen painkiller and caffeine may increase risk of liver damage
11. MIT: Human-generated ozone will damage crops
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/8/2017)... About Voice Recognition Biometrics Voice recognition biometrics ... a stored voiceprint template. Acoustic features of an ... are compared to distinguish between individual voices. Voice ... PCs already have a microphone and can authenticate ... are most likely to be deployed in telephone-based ...
(Date:2/8/2017)... , Feb. 7, 2017 The biometrics ... by the confluence of organizations, desires to better ... knowledge-based systems (password and challenge questions), biometrics is ... government systems. The market is driven by use ... between consumer and enterprise uses cases, with consumer-facing ...
(Date:2/7/2017)... Zimmer Biomet Holdings, Inc. (NYSE and SIX: ... at the LEERINK Partners 6th Annual Global Healthcare Conference ... February 15, 2017 at 10 a.m. Eastern Time. ... be accessed at http://wsw.com/webcast/leerink28/zbh .  The webcast will ... Biomet,s Investor Relations website at http://investor.zimmerbiomet.com . ...
Breaking Biology News(10 mins):
(Date:2/23/2017)... Atlanta, it seems everyone has a chance to express their ... expressive and dynamic community unlike any other. The businesses that ... With their newest salon in ... on that tradition with a unique, fresh approach to head ... the newest of 13 nationwide locations, each of them well-situated ...
(Date:2/23/2017)... , Feb. 23, 2017  Imanis Life Sciences ... line of oncolytic vaccinia viruses for virotherapy research. ... part of Genelux,s proprietary, vaccinia virus-based technology platform ... to enter into a partnership with Genelux to ... vaccinia viruses for use in research," said Dr. ...
(Date:2/23/2017)... ... February 23, 2017 , ... ... that in a published evaluation of multiple immunoassay-based threat detection technologies by ... Energy Laboratory, PathSensors’ CANARY® biosensor threat detection technology was found to have ...
(Date:2/23/2017)... ... February 23, 2017 , ... Today, ... cortisol, CRP, adiponectin, uric acid, and/or other biomarkers or SNPs of interest) using ... Salimetrics’ SalivaLab , the relationship between insulin and other relevant biomarkers can ...
Breaking Biology Technology: