Navigation Links
Chromosomes show off their shapes
Date:11/25/2013

sequences into reliable maps describing contacts between genes along individual chromosomes. Given these maps, the team, in collaboration with Dr. Ernest Laue of Cambridge University, was able to produce 3-D models of individual chromosome structures.

Interestingly, the new high resolution depictions of chromosomal architecture indicate that the structure of the same DNA molecule can vary markedly between different cells. At the same time, the results point to some basic principles that underlie the genes' organization. Their arrangement appears to be modular and based on the functions of the thousands of genes embedded within each chromosome. The data suggests that chromosomes expose the more active genes at their boundaries, possibly allowing these genes better access to the cellular machinery that regulates them.

Besides giving us a unique, surprising view of the structure of the chromosomes in our cells, the researchers believe that their method will present genetics research with a powerful new tool. For example, it may help uncover the variations in genetic activity between different types of cells, or promote understanding of the mechanisms determining gene activity or quiescence in various normal or disease conditions. The rapidly increasing power of massive DNA sequencing promises to make studies such as this even more powerful in the near future.


'/>"/>

Contact: Yivsam Azgad
news@weizmann.ac.il
972-893-43856
Weizmann Institute of Science
Source:Eurekalert

Page: 1 2

Related biology news :

1. UMMS researchers answer century old question about 3D structure of mitotic chromosomes
2. X chromosomes: Undoing a hairpin doubles gene activity
3. A closer look at chromosomes
4. Western aspen trees commonly carry extra set of chromosomes
5. Study of fruit fly chromosomes improves understanding of evolution and fertility
6. Men can rest easy - sex chromosomes are here to stay
7. Discovery reveals chromosomes organize into yarns
8. Men with prostate cancer who ate a low-fat fish oil diet showed changes in their cancer tissue
9. USC study reveals a protein that keeps people -- and their skeletons -- organized
10. How pigeons may smell their way home
11. Chewing their way to success
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/15/2014)... generally considered to be a disorder of brain development ... environmental, with other neurodevelopmental disorders such as autism and ... is determined by the combined effects of a complex ... factors. , However, longitudinal brain imaging studies in both ... map the disturbances in brain structures as they emerge, ...
(Date:9/15/2014)... the balance between ridding the body of a dangerous ... report appearing in The Journal of Experimental ... cause chronic infections in roughly three-quarters of infected people, ... including cirrhosis and cancer. A few patients successfully eliminate ... + T cells. The protective effects of CD8 ...
(Date:9/15/2014)... German . ... energy carrier natural gas offers a variety of options ... consequent market penetration is still pending because of a ... the Helmholtz Centre for Environ-mental Research (UFZ) and the ... the IEA Task 37 (Energy from Biogas) and the ...
Breaking Biology News(10 mins):Brain Development in Schizophrenia Strays from the Normal Path 2The biomethane market needs clear frame conditions for further growth 2The biomethane market needs clear frame conditions for further growth 3
... The Pollution Prevention Institute at Kansas State University is ... National Pollution Prevention Roundtable. The K-State institute,s intern ... Prevention Program award, also called the MVP2 award, as ... presented Tuesday, Sept. 22, in Washington, D.C. The ...
... - NiKem Research is pleased to announce that ... certification of its bioanalysis facilities to further extend its drug ... years high quality cost-effective bioanalytical support both for its ... PK services associated to various drug discovery programs and as ...
... new study shows that parents are more likely to understand ... a traffic light, than the standard charts currently in use. ... to parent could lead to parents earlier awareness of their ... lifestyle changes," says Eliana Perrin, M.D., M.P.H., senior and corresponding ...
Cached Biology News:K-State Pollution Prevention Institute's intern program named best 2NiKem Research receives certification for GLP Bioanalysis 2UNC study: Color-coded chart improves parents' understanding of body mass index 2
(Date:9/15/2014)... Northeastern University has developed a novel method for ... of nanocarbon structures in carbon nanotube arrays. The ... allow the researchers to tailor the physical properties ... from electronic devices to CNT-reinforced composite materials found ... Their findings were published in the journal ...
(Date:9/15/2014)... Calif. , Sept. 15, 2014 ... new viral transport solution for safe ambient temperature ... to molecular testing. Importantly, the infectivity of agents in ... while maintaining the integrity of the viral nucleic ... of the recent Ebola epidemic in ...
(Date:9/15/2014)... 15, 2014 Research and Markets has ... by Product, by Services, by Technology, by Application - Global ... Whole Exome Sequencing (WES) is next-generation technology used for ... exon. The exome, which is the total of all exons ... and is actually converted into proteins after translation. It is ...
(Date:9/15/2014)... Applied Silicone Corporation, a global ... medical device and critical healthcare market, introduces a ... medical device market. The Dual Matrix Gel ... silicone gel with improved fracture resistance, cohesive strength, ... of two crosslinked networks working in conjunction to ...
Breaking Biology Technology:Northeastern University Researchers Develop Novel Method for Working with Nanotubes 2Safe storage and transport of Ebola, Mers-CoV, and other viruses: Groundbreaking viral inactivation solution capable of preserving nucleic acids 2Safe storage and transport of Ebola, Mers-CoV, and other viruses: Groundbreaking viral inactivation solution capable of preserving nucleic acids 3Global Whole Exome Sequencing (Systems, Kits, Library Preparation, Target Enrichment) Market by Product, by Services, by Technology, by Application - Forecast to 2018 2Global Whole Exome Sequencing (Systems, Kits, Library Preparation, Target Enrichment) Market by Product, by Services, by Technology, by Application - Forecast to 2018 3Applied Silicone Launches Silicone Gel System with Dual Matrix Technology 2
... Barr,Pharmaceuticals, Inc. (NYSE: BRL ) today ... approval from the U.S. Food & Drug,Administration (FDA) ... version of Forest Pharmaceuticals, Inc.,s Combunox(R) (oxycodone,HCl and ... of the New Combination exclusivity period for Combunox. ...
... N.C., Nov. 29 Kent Riddle, Director,Product Development, for ... to head development initiatives within the Medical,Biodevice Sector. The ... the growth of bioscience in North Carolina., "I ... part of this important,group," says Riddle. "DPI is at ...
... The Center for Molecular,Medicine (CMM) today announced ... Xceed,Molecular (http://www.xceedmolecular.com ; Wellesley, MA) collaborator program., ... US site to offer Xceed Molecular,s new,Ziplex(R) system ... tool in disease investigation and drug discovery. Analysis ...
Cached Biology Technology:Barr Receives Approval for Generic Combunox(R) Tablets, 5mg/400mg 2Barr Receives Approval for Generic Combunox(R) Tablets, 5mg/400mg 3Center for Molecular Medicine Offers Xceed Ziplex(TM) Services to Research Community 2
... power of your ValveBank system! Program ... a Macintosh computer using graphic 'click-and-drag' timebars. ... print out program listings, then download your ... simple step., EasyCode is used for programming ...
...
... The Jouan MSC series of ... comfortable working conditions and certification to ... automatic regulation ensures that the cabinets ... working conditions. Natural lighting, low noise ...
... HB-1000 Hybridizer hybridization ovens are designed to create ... Temperature control (ambient to 99.9C) , ... consistent saturation of samples, whether it be for ... which displays the current temperature inside the chamber, ...
Biology Products: