Navigation Links
Chromosome 'anchors' organize DNA during cell division
Date:12/20/2012

LA JOLLA, CA----For humans to grow and to replace and heal damaged tissues, the body's cells must continually reproduce, a process known as "cell division," by which one cell becomes two, two become four, and so on. A key question of biomedical research is how chromosomes, which are duplicated during cell division so that each daughter cell receives an exact copy of a person's genome, are arranged during this process.

Now, scientists at the Salk Institute have discovered a new characteristic of human cell division that may help explain how our DNA is organized in the nucleus as cells reproduce. They found that telomeres, molecular caps that protect the ends of the chromosomes, move to the outer edge of the cell's nucleus after they have been duplicated.

While the implications of this spatial reorganization of telomeres are not yet clear, the findings may shed light on how our genes are regulated and how gene expression programs are altered during cell division, an important step in understanding aging and diseases that stem from genetic mutations, such as cancer.

"What we discovered is that telomeres not only protect our chromosomes, they also help organize our genetic material in the nucleus," says Jan Karlseder, a professor in Salk's Molecular and Cell Biology Laboratory and the Donald and Darlene Shiley Chair. "This is important, because the three-dimensional position of DNA in the nucleus influences gene expression profiles and how the genome morphs over time."

Telomeres, a combination of proteins and DNA, are crucial in DNA replication, tumor suppression and aging. Every time a primary human cell divides, its telomeres get shorter, until critically short telomeres lead cells to self-destruct. Much of Karlseder's research has focused on understanding telomere dynamics in order to develop ways to influence the aging process, and as a result, restrict cancer cell growth.

In addition to exploring the involvement of
'/>"/>

Contact: Andy Hoang
ahoang@salk.edu
619-861-5811
Salk Institute
Source:Eurekalert  

Page: 1 2

Related biology news :

1. From Mediterranean coasts to Tatra Mountains and beyond: Plant chromosome number variation
2. Extra chromosome 21 removed from Down syndrome cell line
3. Western aspen trees commonly carry extra set of chromosomes
4. Study of fruit fly chromosomes improves understanding of evolution and fertility
5. Men can rest easy - sex chromosomes are here to stay
6. Discovery reveals chromosomes organize into yarns
7. Music with dinner: Whales sing during foraging season, not just while breeding
8. Abuse during childhood linked to adult-onset asthma in African-American women
9. Insight into DNA reprogramming during egg and sperm cell development
10. OHSU study shows that a molecule critical to nerve cells increases drammatically during hypertension
11. New risk factor identified for high blood pressure during pregnancy
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Chromosome 'anchors' organize DNA during cell division
(Date:10/18/2014)... In a sample of patients with undiagnosed, suspected genetic ... associated with a higher molecular diagnostic yield than traditional ... JAMA . The study is being released to ... meeting. , Exome sequencing, which sequences the protein­coding region ... genetic material present in a cell or organism), has ...
(Date:10/17/2014)... Researchers from the University of Copenhagen have shown for ... the lungs of Cystic fibrosis patients, giving them the ... growth in chronic infections. , The study also discovered ... fibrosis (CF) patients was halted or slowed down by ... consumed all the oxygen and helped "suffocate" the bacteria, ...
(Date:10/16/2014)... of Marine Science have received a 3-year, $392,773 ... the streams and wetlands most vulnerable to sea-level ... governments and citizens conserve these important ecosystems. , ... tidal-marsh observations first gathered by VIMS scientists in ... today,s researchers accurately map the slow but inexorable ...
Breaking Biology News(10 mins):Study examines type of exome sequencing and molecular diagnostic yield 2Study examines type of exome sequencing and molecular diagnostic yield 3Scientists opens black box on bacterial growth in cystic fibrosis lung infection 2EPA grant will help localities conserve headwater wetlands 2EPA grant will help localities conserve headwater wetlands 3
... Expectant mothers who eat excessive quantities of liquorice during ... a study has shown. A study of eight ... liquorice when pregnant found they did not perform as ... were also more likely to have poor attention spans ...
... lower children,s risk of allergy. Cathleen Muche-Borowski and her ... in the current issue of Deutsches rzteblatt International ... diseases are becoming increasingly common in Western industrialized countries. ... allergic asthma, hay fever, or atopic eczema, the prevention ...
... available in German . , A knowledge ... scientists have been asking themselves whether, and to what extent ... enlarge the cloud cover and thus curb climate warming. Research ... scientists from the Max Planck Institute for Meteorology in Hamburg ...
Cached Biology News:Eating liquorice in pregnancy may affect a child's IQ and behavior 2Do dust particles curb climate change? 2Do dust particles curb climate change? 3Do dust particles curb climate change? 4
(Date:10/19/2014)... The Latin American hardware encryption display market report ... analysis and forecast of revenue. This market was valued ... reach $2,366.8 million by 2018, at a CAGR of ... TOC of the Latin American hardware encryption market report ... It also provides a glimpse of the segmentation of ...
(Date:10/19/2014)... 2014 NextCODE Health, which enables clinicians and researchers ... time, today announced the launch of its new genomic data ... the American Society of Human Genetics (ASHG) annual meeting in ... up and apply for free beta access, visit www.nextcode.com ... can be viewed here . The Exchange: ...
(Date:10/19/2014)... The Asian Automatic patient billing report defines and segments ... revenue. The Automatic patient billing market in Asia is ... at a developing CAGR of 7.2% from 2013 to ... Automatic patient billing market, to get an idea of ... of the segmentation of this market in the same ...
(Date:10/19/2014)... report "Chocolate, Cocoa Beans, Lecithin, Sugar and Vanilla Market ... (2011 - 2016)," analyzes the chocolate market by ... market drivers, restraints, and opportunities for the chocolate market ... chocolate market is expected to grow from $83.2 billion ... CAGR of 2.7% from 2011 to 2016. , Get ...
Breaking Biology Technology:The Latin American hardware encryption display market is expected to reach $2,366.8 million by 2018 - New Report by MicroMarket Monitor 2The Latin American hardware encryption display market is expected to reach $2,366.8 million by 2018 - New Report by MicroMarket Monitor 3The NextCODE Exchange: The first global, real-time system for sharing full-resolution genomic data 2The NextCODE Exchange: The first global, real-time system for sharing full-resolution genomic data 3The Asian Automatic patient billing market is estimated to grow to around $463.9 million by 2018 - New Report by MicroMarket Monitor 2The Asian Automatic patient billing market is estimated to grow to around $463.9 million by 2018 - New Report by MicroMarket Monitor 3Chocolate Market Projected To Reach $98.3 Billion by 2016 - New Report by MarketsandMarkets 2Chocolate Market Projected To Reach $98.3 Billion by 2016 - New Report by MarketsandMarkets 3Chocolate Market Projected To Reach $98.3 Billion by 2016 - New Report by MarketsandMarkets 4
... Bayer HealthCare Pharmaceuticals Inc. announced today that its investigational ... designation by the U.S. Food and Drug Administration (FDA) ... gastrointestinal stromal tumors (GIST) whose disease has progressed despite ... Regorafenib is an investigational agent and ...
... MiMedx Group, Inc. (OTC BB: MDXG), ... biomaterial-based products, announced today that it will present at ... at the Hard Rock Hotel in Hollywood, Florida. Parker ... President and COO, Michael J. Senken, Chief Financial Officer ...
... -- American Oriental Bioengineering, Inc. (NYSE: ... company dedicated to improving health through the development, ... prescription and over–the-counter ("OTC") products, today announced financial ... 2011. First Quarter 2011 Financial ...
Cached Biology Technology:FDA Grants Fast Track Designation to Bayer's Investigational Compound Regorafenib for the Treatment of Gastrointestinal Stromal Tumors 2FDA Grants Fast Track Designation to Bayer's Investigational Compound Regorafenib for the Treatment of Gastrointestinal Stromal Tumors 3American Oriental Bioengineering Reports First Quarter 2011 Financial Results 2American Oriental Bioengineering Reports First Quarter 2011 Financial Results 3American Oriental Bioengineering Reports First Quarter 2011 Financial Results 4American Oriental Bioengineering Reports First Quarter 2011 Financial Results 5
...
... LF (Low Flow) offers the same benefits as ... applications where control is critical or flow is ... automates the flow of gas in proportion to ... current or pulse width modulation; closed loop feedback ...
Hamster Serum; U.S. sourced, ideal for those who seek an uncompromising quality. Low Hemoglobin levels; U.S. sourced, ideal for those who seek an uncompromising quality. Low Hemoglobin levels....
... CyScribe First-Strand cDNA Labeling Kit with ... For the generation and purification of ... packaged together for complete cDNA labeling ... be used for performing labeling reactions ...
Biology Products: