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Chromosomal translocations point the way toward personalized cancer care
Date:8/13/2012

Sometimes even when we know a translocation is important, we might not be able to do anything about it," Wang says. "Sometimes these translocations might be present in healthy cells that we don't want to kill or some genes involved in translocations may be essential factors for cell survival. For example, we know that c-myc gene is upregulated in specific type of lymphomas but targeting c-myc gene will result in very high toxicity. Or in still other cases drugging the target can be more difficult than in others."

Today's challenge may be tomorrow's cure. Right now we're in the midst of a cancer care revolution toward personalized care based on a cancer's genetic signature and the study and exploitation of chromosomal translocations may lead the way.


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Contact: Garth Sundem
garth.sundem@ucdenver.edu
University of Colorado Denver
Source:Eurekalert

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