Navigation Links
Cholesterol transporter structure decoded
Date:3/21/2014

just clues about how cholesterol is transported into the mitochondria. "We now also have a much better understanding of how TSPO recognizes and binds to diagnostic markers and drugs", explains Markus Zweckstetter, head of research groups at the German Center for Neurodegenerative Diseases (DZNE), at the Max Planck Institute for Biophysical Chemistry, and at the Center for Nanoscale Microscopy and Molecular Physiology of the Brain (CNMPB) at the University Medical Center of Gttingen (UMG).

TSPO has long been successfully used in diagnostics and treatment of a number of diseases. "When the brain is injured or inflamed, its cells produce more TSPO. This fact is used in the diagnosis of neurodegenerative diseases such as Parkinson's and Alzheimer's", explains Stefan Becker, a protein chemist and Max Planck researcher who works next door to Zweckstetter.

Physicians also use radioactively tagged molecules such as PK11195 to visualize inflamed areas of the brain. A detailed understanding of how TSPO binds to such markers opens up novel paths for diagnostic imaging and could constitute an important step along the way to early detection of such diseases and inflammations.

TSPO also binds several medicinal drugs such as diazepam, also known by the trade name of Valium. Not only is diazepam a widely prescribed sedative; it is also used in the treatment of anxiety and epileptic seizures. The Gttingen researchers hope that detailed information about the transporter's structure will help to develop new TSPO-binding drugs.


'/>"/>
Contact: Markus Zweckstetter
markus.zweckstetter@dzne.de
49-551-201-2220
DZNE - German Center for Neurodegenerative Diseases
Source:Eurekalert

Page: 1 2

Related biology news :

1. Cholesterol study suggests new diagnostic, treatment approach for prostate cancer
2. Strawberries lower cholesterol
3. Cleveland Clinic researchers discover process that turns good cholesterol bad
4. Wayne State cholesterol study shows algal extracts may counter effects of high fat diets
5. High cholesterol fuels the growth and spread of breast cancer
6. Amgen Presents Pooled Analysis Showing AMG 145 Significantly Reduced LDL Cholesterol In Over 1,200 Patients
7. Nordic diet lowers cholesterol, study finds
8. 4 genes indentified that influence levels of bad cholesterol
9. U-M researchers find new way to clear cholesterol from the blood
10. Cholesterol rafts deliver drugs inside cancer cells
11. Researchers find alternative cholesterol-lowering drug for patients who cant tolerate statins
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/2/2015)...   Neurotechnology , a provider of high-precision biometric, ... Software Development Kit (SDK). The SentiGaze algorithm enables ... webcams to track eye movements and generate heatmaps based ... can be used for applications such as analysis of ... SDK can also be used to develop interfaces for ...
(Date:2/23/2015)... Conn. , Feb. 23, 2015 NXT-ID, ... or the "Company"), a biometric authentication company focused on ... has filed provisional patent 62114357 for DISTRIBUTED ... this patent, NXT-ID introduces a new groundbreaking payment method. ... the payment account may only be accessed if both ...
(Date:2/12/2015)... OXFORD, Conn. , Feb. 12, 2015 ... ("NXT-ID" or the "Company"), a biometric authentication company focused ... it has filed provisional patent 62/113114 for ... MULTIPLE DEVICES. The patent further establishes NXT-ID,s ... to its intellectual property portfolio the ability for multiple ...
Breaking Biology News(10 mins):Neurotechnology Releases SentiGaze SDK for Eye Movement Tracking Using Ordinary Webcams 2Neurotechnology Releases SentiGaze SDK for Eye Movement Tracking Using Ordinary Webcams 3NXT-ID Patents Voice Directed Payments 2NXT-ID Patents Voice Directed Payments 3NXT-ID Patents Collaborative Services to Enable the "Internet of Things" 2NXT-ID Patents Collaborative Services to Enable the "Internet of Things" 3
... regenerating spinal cord and brain cells after injury is ... peripheral nerves have no such machinery and can readily ... firmly in place and locked. , Now, two groups ... that braking machinery, adding to understanding of the regulation ...
... the brain can form insulin-producing cells that mimic those ... published in the April 26 issue of PLoS Medicine. ... human patients, Seung Kim, MD, PhD, the lead author ... University School of Medicine, said it could lead to ...
... genetically tweaked to absorb more contaminants, researchers found that ... The results raised hopes that the plants might become ... The new research findings, published Feb. 1 in the ... lines of the Indian mustard plant, Brassica juncea, absorbed ...
Cached Biology News:New component of the 'brakes' on nerve regeneration found 2Stem cells from brain transformed to produce insulin at Stanford 2Stem cells from brain transformed to produce insulin at Stanford 3Transgenic plants remove more selenium from polluted soil than wild plants, new tests show 2Transgenic plants remove more selenium from polluted soil than wild plants, new tests show 3Transgenic plants remove more selenium from polluted soil than wild plants, new tests show 4
(Date:3/3/2015)... March 3, 2015  Thingee Corporation, a software development ... a presentation entitled, "Technology Adoption: Making Reps, Lives Easier" ... Innovations and Technology ,  in Deerfield Beach, ... 13, 2015. Audiences looking to learn how technology can ... to be in the audience for the Thingee presentation. ...
(Date:3/3/2015)... 03, 2015 Becht Engineering Co., ... it has acquired The CECON Group, Inc., located ... were not announced. , Becht Engineering (http://www.becht.com ... sector including oil and gas production, refining, petrochemical, ... nuclear power sectors. The company has twelve offices ...
(Date:3/3/2015)... , Mar. 03, 2015 Research and Markets ... Jain PharmaBiotech,s new report "RNAi - Technologies, Markets ... Because of its ability to silence any gene ... as the research tool to discriminate gene function. After ... be designed to target every gene in the genome ...
(Date:3/3/2015)... DNA Diagnostics Center (DDC), one of the largest ... 20 th anniversary today. Headed by President and ... services company that focuses on DNA testing across multiple ... generates a significant portion of sales across international markets ... Peter Vitulli acknowledges the anniversary of the ...
Breaking Biology Technology:Thingee to present at 11th Annual Synergistix Users Conference 2Global RNAi Market Report 2015 - Technologies, Markets and Companies 2014-2024 2Global RNAi Market Report 2015 - Technologies, Markets and Companies 2014-2024 3DNA Diagnostics Center, One of The World's Largest DNA Testing Labs, Celebrates Their 20th Anniversary 2DNA Diagnostics Center, One of The World's Largest DNA Testing Labs, Celebrates Their 20th Anniversary 3
... PARIS, June 21, 2011 Industry leaders from the ... the Aerospace Industries Association of America (AIA) reaffirmed their ... during an annual meeting at the 2011 Paris Airshow. ... reducing aviation,s environmental impacts," Jim Albaugh, Chairman of the ...
... Waife & Associates, Inc. (W&A), change management consultants ... the consulting practice of Mark Di Ianni, MDI Consulting ... has been a senior executive in the CRO (contract ... a series of successful companies. In recent years his ...
... Michigan, June 21, 2011 , ... pleased to announce that its,US-subsidiary NextGen Sciences Inc, ... launched its first cerebrospinal,fluid (CSF) multiple protein ... (CNS) biomarker,discovery and qualification . The assay simultaneously ...
Cached Biology Technology:Aerospace CEOs Discuss Joint Approach to Environment, Air Traffic Management, and Other Key Issues 2Aerospace CEOs Discuss Joint Approach to Environment, Air Traffic Management, and Other Key Issues 3Waife & Associates, Inc. Adds Mark Di Ianni as Principal Consultant 2NextGen Sciences Launches Multiple Protein cerebrospinal fluid (CSF) CNS Disease Biomarker Assay 2NextGen Sciences Launches Multiple Protein cerebrospinal fluid (CSF) CNS Disease Biomarker Assay 3
Applications: Western blotting ...
Ethylene glycol-bis(2-aminoethyl ether)-N,N,N',N'-tetraacetic acid, Molecular Biology Grade...
Required to perform reference file generation, flatfield calibration and performance verification processes on the GSD-501...
... 100 reactions. Prepare circular DNA templates ... microgram quantities of template DNA from ... DNA directly for cycle sequencing without ... liquid cultures, colonies, plaques, or purified ...
Biology Products: