Navigation Links
Cholesterol transporter structure decoded
Date:3/21/2014

This news release is available in German.

The word "cholesterol" is directly linked in most people's minds with high-fat foods, worrying blood test results, and cardiovascular diseases. However, despite its bad reputation, cholesterol is essential to our wellbeing: It stabilizes cell membranes and is a raw material for the production of different hormones in the cell's power plants the mitochondria. Now, for the first time, scientists in Gttingen have solved the high-resolution structure of the molecular transporter TSPO, which introduces cholesterol into mitochondria. This protein also serves as a docking site for diagnostic markers and different drugs, such as Valium. The detailed knowledge of its three-dimensional shape and function opens up new diagnostic and therapeutic perspectives.

Not only are mitochondria the most important energy supplier in living cells. They also produce steroid hormones such as testosterone and oestradiol, which control many processes in the body. The raw material for the production of steroid hormones is cholesterol, which must first be transported into mitochondria across two membranes. This difficult task is carried out by a molecular transport protein named TSPO in the outer mitochondrial membrane. Using nuclear magnetic resonance spectroscopy, two teams working with the Gttingen-based scientists Markus Zweckstetter and Stefan Becker have now shown the complex three-dimensional structure of the protein "at work" in atomic detail.

The researchers achieved this methodical breakthrough by applying an ingenious trick: In their experiments, they coupled the transporter to an important diagnostic marker called PK11195; it was this complex that first gave the scientists analyzable results. In fact, the TSPO structure delivers more than
'/>"/>

Contact: Markus Zweckstetter
markus.zweckstetter@dzne.de
49-551-201-2220
DZNE - German Center for Neurodegenerative Diseases
Source:Eurekalert

Page: 1 2

Related biology news :

1. Cholesterol study suggests new diagnostic, treatment approach for prostate cancer
2. Strawberries lower cholesterol
3. Cleveland Clinic researchers discover process that turns good cholesterol bad
4. Wayne State cholesterol study shows algal extracts may counter effects of high fat diets
5. High cholesterol fuels the growth and spread of breast cancer
6. Amgen Presents Pooled Analysis Showing AMG 145 Significantly Reduced LDL Cholesterol In Over 1,200 Patients
7. Nordic diet lowers cholesterol, study finds
8. 4 genes indentified that influence levels of bad cholesterol
9. U-M researchers find new way to clear cholesterol from the blood
10. Cholesterol rafts deliver drugs inside cancer cells
11. Researchers find alternative cholesterol-lowering drug for patients who cant tolerate statins
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/18/2014)... many times it,s demonstrated, it,s still hard to ... But by using a signaling system called "quorum ... to suit their population. In short, some bacteria ... act accordingly. , Once the population of quorum-sensing ... innocuous to pathogenic, or from unhelpful to helpful. ...
(Date:9/18/2014)... built the first smartphone app that automatically reveals ... In other words, your smartphone knows your state ... and how that affects you. , The StudentLife ... loneliness to their academic performance, also may be ... to monitor mental health, trigger intervention and improve ...
(Date:9/18/2014)... will be celebrated tonight at the third annual Golden ... health of premature infants and in paving the way ... work was supported by the National Science Foundation, the ... Commission, will be honored at a ceremony at the ... of Members of Congress will be on hand to ...
Breaking Biology News(10 mins):Researchers study vital 'on/off switches' that control when bacteria turn deadly 2Researchers study vital 'on/off switches' that control when bacteria turn deadly 3New Dartmouth smartphone app reveals users' mental health, performance, behavior 2New Dartmouth smartphone app reveals users' mental health, performance, behavior 3New Dartmouth smartphone app reveals users' mental health, performance, behavior 43rd annual Golden Goose award ceremony honors 8 researchers; Unusual work had big results 2
... not always what they seem when it comes to fishsomething ... are finding out. Using modern genetic analysis, combined with traditional ... thought to be three species of blenny in the genus ... findings are published in the scientific journal ZooKeys , ...
... developed a little bomb that promises a big bang for ... loosely attached to gold nanoparticles starts accumulating deep inside tumors ... effective treatment within two hours. The same drug injected alone ... the surface a far less effective route. The ...
... it is relatively common to come across petrol stations surrounded ... of Murcia (UM) have studied the effects of contamination at ... be noted in buildings less than 100 metres from the ... benzene, which increases the risk of cancer have been ...
Cached Biology News:Smithsonian scientists discover 7 new species of fish 2A loose grip provides better chemotherapy 2Petrol stations pollute their immediate surroundings 2
(Date:9/18/2014)... 2014 Texas Governor Rick Perry, ... A&M Health Science Center CEO Brett Giroir, M.D., ... and Human Services (HHS), State of Texas and ... influenza vaccine manufacturing facility in Bryan, Texas, which ... the Texas A&M Biocorridor – a rapidly evolving ...
(Date:9/18/2014)... 2014 Research and Markets ... N-acetylcysteine Industry Report 2014" report to their ... Report 2014 is a professional and in-depth study ... industry. The report provides a basic ... and industry chain structure. The N-acetylcysteine market analysis ...
(Date:9/18/2014)... 18, 2014 Leatherwood Plastics has ... material, to stay competitive in the semiconductor, clean ... materials ultimately impact product quality and productivity, according ... , Established in 1980 in Lewisville, TX, ... fabricators have left the business. Much of Leatherwood’s ...
(Date:9/18/2014)... Sept. 18, 2014  Neogen Corporation (Nasdaq: ... a strategic agreement with Merck Animal Health to market ... The Igenity Dairy Heifer Program consists of genomic ... the genetic potential of replacement dairy heifers. The genomic ... born, and is an excellent tool in the decision-making ...
Breaking Biology Technology:Texas A&M Dedicates National Pandemic Influenza Vaccine Manufacturing Facility, on Track for 2016 Start-Up Phase 2Texas A&M Dedicates National Pandemic Influenza Vaccine Manufacturing Facility, on Track for 2016 Start-Up Phase 3Texas A&M Dedicates National Pandemic Influenza Vaccine Manufacturing Facility, on Track for 2016 Start-Up Phase 4Global N-acetylcysteine Industry Report 2014 2Leatherwood Plastics Selects Vycom’s Flametec PVC-C Material to Stay Competitive in Semiconductor and Lab Equipment Industries 2Merck Animal Health to market Neogen's dairy genomic program 2
... /PRNewswire-FirstCall/ - GeneNews Limited (TSX: GEN),a company ... the early,detection of diseases and personalized health ... world,s first blood-based molecular test,for colorectal cancer ... a patient,s current risk of having colorectal ...
... Abingdon Life Sciences,announces the formal opening of ... 5963 La Place Court, Suite 107, are in ... Abingdon Life Sciences,Inc. is a first-in-class Drug, Device, ... and device companies with,superior services based on an ...
... Monday, July 21, 2008 - 11:00 a.m. ET; 8:00 ... 18 /PRNewswire-FirstCall/ - MIGENIX,Inc. (TSX: MGI; OTC: MGIFF), a ... conference call and webcast on Monday,July 21, 2008 at ... results,for the fourth fiscal quarter and fiscal year ended ...
Cached Biology Technology:GeneNews launches world's first blood test for colorectal cancer screening 2GeneNews launches world's first blood test for colorectal cancer screening 3Abingdon Life Sciences, Inc. Announces Opening of Office in Carlsbad, Ca. 2
The 12-Tube Magnetic Separation Rack is designed to be used for small-scale separations using magnetic particles. ,Capacity: 12 microcentrifuge tubes. ,Magnets: Neodymium rare earth permanent ma...
...
No description available in Ensembl Antigen: Recombinant Protein Epitope Signature Tag (PrEST)....
15(S)-HETE-d8 is used as an internal standard for the quantification of 15(S)-HETE by stable isotope dilution mass spectrometry....
Biology Products: