Navigation Links
Cholesterol study suggests new diagnostic, treatment approach for prostate cancer
Date:3/4/2014

validated through further examination of a large number of tissue biopsies and correlation assessment of cholesteryl ester levels and clinical outcomes of patients."

A critical focus of the research is the analysis of individual lipid droplets inside single cells. Purdue researchers have developed an analytical tool called Raman spectromicroscopy that allows compositional analysis of single lipid droplets in living cells and mice.

"It is conceivable that cancer cells require reservoirs for lipids, namely lipid droplets. However, our imaging data revealed an unexpected, aberrant accumulation of esterified cholesterol in lipid droplets of high-grade prostate cancer and metastases," Cheng said.

The researchers learned that cholesteryl ester accumulation, which occurs only in advanced prostate cancer and its metastasis, results from the loss of a tumor-suppressing gene called PTEN and the activation of an intracellular metabolic pathway promoting tumor growth.

"These findings improve current understanding of the role of cholesterol in cancer and also suggest new opportunities for the diagnosis and treatment of aggressive prostate cancer. We have been pleased to be able to collaborate with Dr. Cheng on his important research" said Michael Koch, John P. Donohue Professor of Urology and chair of the Department of Urology at IU School of Medicine.

Findings show the drugs avasimibe and Sandoz 58-035 reduced the accumulation of cholesteryl ester and significantly hindered advanced prostate cancer growth in laboratory cell cultures and xenograft mouse models. These drugs did not show toxicity to animals.

"We note that avasimibe, Sandoz 58-035 and a class of similar drugs were developed to treat atherosclerosis, but the clinical trials were halted due to the lack of effectiveness in reducing plaque size," Cheng said. "The present study highlights a novel use of these drugs to treat advanced prostate cancer."


'/>"/>
Contact: Emil Venere
venere@purdue.edu
765-494-4709
Purdue University
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Strawberries lower cholesterol
2. Cleveland Clinic researchers discover process that turns good cholesterol bad
3. Wayne State cholesterol study shows algal extracts may counter effects of high fat diets
4. High cholesterol fuels the growth and spread of breast cancer
5. Amgen Presents Pooled Analysis Showing AMG 145 Significantly Reduced LDL Cholesterol In Over 1,200 Patients
6. Nordic diet lowers cholesterol, study finds
7. 4 genes indentified that influence levels of bad cholesterol
8. U-M researchers find new way to clear cholesterol from the blood
9. Cholesterol rafts deliver drugs inside cancer cells
10. Researchers find alternative cholesterol-lowering drug for patients who cant tolerate statins
11. Study identifies liver gene that regulates cholesterol and fat blood levels
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Cholesterol study suggests new diagnostic, treatment approach for prostate cancer
(Date:7/25/2014)... a molecular testing panel developed at UPMC greatly ... surgery for patients with thyroid nodules and cancer, ... Institute (UPCI), partner with UPMC CancerCenter., The test, ... other diagnostic testing agencies, improved the chances of ... percent, according to the study published this month ...
(Date:7/25/2014)... , July 25, 2014 Biometrics ... are turning to digital technology for online & commerce ... Google Inc. (NASDAQ: GOOG ), LifeLock Inc. ... V ), Apple Inc. (NASDAQ: AAPL ... Inc., (OTCQB: NXTD) a biometric authentication company focused on ...
(Date:7/24/2014)... how wildlife loss leads to conflict among people around ... Conservation Society (WCS) Health & Ecosystems: Analysis of Linkages ... interdisciplinary approach to tackle global biodiversity decline. , The ... the world,s people and provides protein for more than ... as no surprise that today,s unprecedented loss of wildlife, ...
Breaking Biology News(10 mins):Test increases odds of correct surgery for thyroid cancer patients 2Test increases odds of correct surgery for thyroid cancer patients 3Consumer Needs for Identity Theft Security Grows with Popularity of Latest Smart Technology Products - Biometrically Secure Digital Wallet to Replace Credit Card Dependency 2Consumer Needs for Identity Theft Security Grows with Popularity of Latest Smart Technology Products - Biometrically Secure Digital Wallet to Replace Credit Card Dependency 3Consumer Needs for Identity Theft Security Grows with Popularity of Latest Smart Technology Products - Biometrically Secure Digital Wallet to Replace Credit Card Dependency 4Consumer Needs for Identity Theft Security Grows with Popularity of Latest Smart Technology Products - Biometrically Secure Digital Wallet to Replace Credit Card Dependency 5Consumer Needs for Identity Theft Security Grows with Popularity of Latest Smart Technology Products - Biometrically Secure Digital Wallet to Replace Credit Card Dependency 6New study draws links between wildlife loss and social conflicts 2
... the time, the immune system is the body,s protector, warding ... infection and disease. But in autoimmune diseases, the immune ... attacking normal cells. A major discovery by La Jolla ... previously unknown molecular interaction that is essential for T lymphocyte ...
... team of Russian veterinary colleagues and health experts from the ... distemper -- a virus afflicting domestic dogs and many wildlife ... tigers. The team presented its results at the first-ever ... Russian Far East city of Ussurisk. The symposium underscores ...
... stem cell therapies will be among the research topics ... on Cardiovascular Regenerative Medicine, which will be held Oct. ... into the state of the regenerative medicine field. ... Lung, and Blood Institute and the Foundation for the ...
Cached Biology News:La Jolla Institute discovers previously unknown cell interaction key in immune system attacks 2La Jolla Institute discovers previously unknown cell interaction key in immune system attacks 3Russian and US veterinarians collaborate to solve mysterious wild tiger deaths 2Russian and US veterinarians collaborate to solve mysterious wild tiger deaths 3NIH hosts Cardiovascular Regenerative Medicine Symposium Oct. 4-5 2
(Date:7/24/2014)... to materialise. Yet, scientists are making progress in ... One such approach relies on quantum dotsa kind ... electric field. A new study demonstrates that changing ... (TQDs) with electrical impulses can help better control ... be used as quantum information units, which would ...
(Date:7/24/2014)... Although most natural and synthetic processes prefer to ... potential or energyit is within the realm of ... experience constant changes in energy and phases, such ... These conditions allow humans to regulate their body ... rumble with seismic activity. , But even ...
(Date:7/24/2014)... Research and Markets has announced ... Analytical Instruments Market 2014-2018" report to their offering. ... Genomics is the study of the gene and its ... and functions of proteomes or sets of proteins by ... involves the mapping of genes and DNA sequencing to ...
(Date:7/24/2014)... July 24, 2014 SRI International has been ... National Institute of Allergy and Infectious Diseases (NIAID), part ... development of potential therapies for HIV infection and AIDS. ... HIV and AIDS and the complications and opportunistic infections ... preventing sexual transmission of HIV. According ...
Breaking Biology Technology:New approach to form non-equilibrium structures 2Global Genomics and Proteomics Analytical Instruments Market 2014-2018: Key Vendors are Agilent, Bio-Rad , F. Hoffmann, La Roche, Illumina, PerkinElmer and Thermo Fisher Scientific 2National Institute of Allergy and Infectious Diseases Awards SRI International Contract to Study New Therapies for HIV and AIDS 2National Institute of Allergy and Infectious Diseases Awards SRI International Contract to Study New Therapies for HIV and AIDS 3
... at Least 227 HyperQ(TM) Systems During the Term of the ... ... Israel, November 10 BSP (Biological,Signal Processing Ltd.) ( http://www.bsp.co.il/ ), ... and,monitoring of Ischemic Heart Disease (IHD), announced that it has signed ...
... at TGH to Enhance Clinical Skills,Development, DENVER, ... new partnership with the University of South Florida ... USF Health hospital,partners and for local and national ... Education Center is located at Tampa,General Hospital, a ...
... NeurogesX, Inc.,(Nasdaq: NGSX ), a biopharmaceutical company ... announced today that,Anthony DiTonno, President and Chief Executive ... Renshaw 10th Annual Healthcare Conference in New,York City ... Stephen Ghiglieri,Chief Financial Officer, will also be available ...
Cached Biology Technology:BSP Signs Agreement With CMP Trading for Distribution of HyperQ(TM) Stress System, for Early Detection of Ischemic Heart Disease, in South Korea 2Medical Simulation Corporation Announces Partnership With University of South Florida 2Medical Simulation Corporation Announces Partnership With University of South Florida 3NeurogesX to Present at Rodman & Renshaw 10th Annual Healthcare Conference 2NeurogesX to Present at Rodman & Renshaw 10th Annual Healthcare Conference 3
Originally developed for the culture of Drosophila; suitable for culture of other dipteran cell lines. Powder, Insect cell culture tested...
... This CLS number is a ... easily match Cornings product number. ... please order under the old ... customer service for assistance. ...
Collected from calves that are 10 days old or less. Sterile, cell culture tested, US Origin...
... GenomePlex Single Cell Whole Genome ... based on random fragmentation of genomic ... small fragments to PCR-amplifiable library molecules ... is achieved by PCR amplification of ...
Biology Products: