Navigation Links
Cholesterol study suggests new diagnostic, treatment approach for prostate cancer
Date:3/4/2014

WEST LAFAYETTE, Ind. - Researchers have discovered a link between prostate cancer aggressiveness and the accumulation of a compound produced when cholesterol is metabolized in cells, findings that could bring new diagnostic and treatment methods. Findings also suggest that a class of drugs previously developed to treat atherosclerosis might be repurposed for treatment of advanced prostate cancer.

The research showed depletion of the compound cholesteryl ester significantly reduced prostate cancer cell proliferation, impaired its ability to invade a laboratory tissue culture and suppressed tumor growth in mice.

"Our study provides an avenue towards diagnosis of aggressive prostate cancer. Moreover, we showed that depleting cholesteryl ester significantly impairs prostate cancer aggressiveness," said Ji-Xin Cheng, a professor in Purdue University's Weldon School of Biomedical Engineering and Department of Chemistry.

The research involved analysis of clinical samples harvested from prostate cancer patients, specialized cell lines and mice.

Findings are detailed in a research paper appearing Tuesday (March 4) in the journal Cell Metabolism. The paper was authored by researchers associated with Purdue's Center for Cancer Research and the Indiana University Melvin and Bren Simon Cancer Center at Indiana University School of Medicine.

"Prostate cancer is the second-leading cause of cancer-related mortality in American men. Our finding offers a biological foundation that supports the beneficial effect of cholesterol-lowering drugs. Second, our study heralds the potential of using cholesteryl ester as a therapeutic target for advanced prostate cancer," said study co-author Timothy Ratliff, the Robert Wallace Miller Director of Purdue's Center for Cancer Research. "These results together suggest that cholesteryl ester accumulation might be used for more accurate prediction of prostate cancer aggressiveness, if
'/>"/>

Contact: Emil Venere
venere@purdue.edu
765-494-4709
Purdue University
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Strawberries lower cholesterol
2. Cleveland Clinic researchers discover process that turns good cholesterol bad
3. Wayne State cholesterol study shows algal extracts may counter effects of high fat diets
4. High cholesterol fuels the growth and spread of breast cancer
5. Amgen Presents Pooled Analysis Showing AMG 145 Significantly Reduced LDL Cholesterol In Over 1,200 Patients
6. Nordic diet lowers cholesterol, study finds
7. 4 genes indentified that influence levels of bad cholesterol
8. U-M researchers find new way to clear cholesterol from the blood
9. Cholesterol rafts deliver drugs inside cancer cells
10. Researchers find alternative cholesterol-lowering drug for patients who cant tolerate statins
11. Study identifies liver gene that regulates cholesterol and fat blood levels
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Cholesterol study suggests new diagnostic, treatment approach for prostate cancer
(Date:12/17/2014)... , Dec. 16, 2014  Automation is fundamentally transforming the ... at international borders. Over the past decade, ePassports, biometric ... to self process through border control via eGates and ... of airports, seaports, and land borders across the globe. ...
(Date:12/11/2014)... Markets , http://photos.prnewswire.com/prnh/20130307/600769 ... addition of the "Biometrics Market in India 2015-2019" ... major trend emerging in this market is the adoption ... than one characteristic of an individual for verification and ...
(Date:12/10/2014)... , Dec. 8, 2014 You,ve been here before: you ... remember your password, site key or the answer to your secret ... Today, Hoyos Labs , a digital infrastructure ... an end to the frustration that comes with usernames, passwords and ...
Breaking Biology News(10 mins):Automated Border Control (ABC) Transforms the Global Travel Experience With More Than 2500 ABC eGates and APC Kiosks Deployed In Airports, Seaports, and Land Borders Worldwide 2Biometrics Market in India 2015-2019: Key Vendors are 3M Cogent, NEC, Safran and Suprema 2The Password is Finally Dead: Launch of 1U Mobile App Eliminates Need for All Usernames and Passwords 2The Password is Finally Dead: Launch of 1U Mobile App Eliminates Need for All Usernames and Passwords 3
... AMHERST, Mass. Military uniforms of the future may ... thanks to research by teams at the University of ... a nanotube-based fabric that repels chemical and biological agents. ... Watkins, collaborating with team leader Francesco Fornasiero of Lawrence ...
... trees is so finely-tuned that predicted increases in drought ... in many species. A recent paper co-authored by George ... finds that those systems in plants around the globe ... making forest ecosystems vulnerable to increasing environmental stress., In ...
... molecules are said to be hydrophobic. The hydration ... is important for many biological processes: protein folding, membrane ... of action potentials across membranes. It is involved as ... the fact that you can get rid of fat ...
Cached Biology News:Developing 'second skin' military fabric to repel chemical and biological agents 2Developing 'second skin' military fabric to repel chemical and biological agents 3Increasing drought stress challenges vulnerable hydraulic system of plants, GW professor finds 2Illuminating the no-man's land of waters' surface 2
(Date:1/22/2015)... Cambridge Semantics, the leading provider of smart data ... was a record-breaking year across the board for the company. ... Data Platform and our Smart Data solutions, our customers were ... which led to record growth for the company in 2014,” ...
(Date:1/22/2015)... Boston, MA (PRWEB) January 22, 2015 ... systems, is pleased to announce an exciting product from a ... of motion analysis solutions over the past 15 years, with ... industries. Most recently, their 3D IMU system (inertial measurement unit), ...
(Date:1/22/2015)... , 22 de enero de 2015  El Dr. ... su llamada a nominaciones para 2015. Este prestigioso premio ... o tiene el potencial para hacer, contribuciones destacadas para ... aceptarán hasta el 15 de marzo de 2015 a ...
(Date:12/25/2014)... 25, 2014 The report “Service Quality ... Type & Provider Type - Global Advancements, Worldwide Forecasts ... an in-depth analysis and forecasting of revenues. , ... 221 pages and in-depth TOC on “Service Quality Management ...
Breaking Biology Technology:Cambridge Semantics Announces Record Results for 2014 23D Motion Capture Just Got Easy 2El Dr. Paul Janssen Award for Biomedical Research emite su llamada a los nominados para 2015 2El Dr. Paul Janssen Award for Biomedical Research emite su llamada a los nominados para 2015 3El Dr. Paul Janssen Award for Biomedical Research emite su llamada a los nominados para 2015 4Service Quality Management Market worth $2.1 Billion & Telco Customer Experience Management Market worth $2.3 Billion by 2019 – New Report by MarketsandMarkets 2Service Quality Management Market worth $2.1 Billion & Telco Customer Experience Management Market worth $2.3 Billion by 2019 – New Report by MarketsandMarkets 3Service Quality Management Market worth $2.1 Billion & Telco Customer Experience Management Market worth $2.3 Billion by 2019 – New Report by MarketsandMarkets 4
... Scarless Hair Transplantation,(International) Medical Chain Institute today announced ... the prestigious Chang,an Avenue West,Beijing, China. The ... and plastics institution for hair transplants in China. ... area of 1,000 square meters, the Hospital is ...
... April 22 Three attorneys who previously worked at ... firm,s Atlanta office. The attorneys include Mark S. Lange, ... department and Larry A. Slovensky, a partner ... welcome good lawyers back into the fold," said MLA ...
... DIEGO, CA, April 23, 2009 Senomyx, Inc. (Nasdaq: ... results on Thursday, May 7, 2009 before the opening of ... a conference call with a live Internet broadcast that will ... quarter results on the same day at 11:00 a.m. Eastern ...
Cached Biology Technology:Lotus Scarless Hair Transplantation (International) Medical Chain Institute Opens New Center on Beijing's Prestigious Chang'An Avenue 2Three Attorneys Rejoin McKenna Long & Aldridge 2SENOMYX, INC. FIRST QUARTER 2009 EARNINGS CONFERENCE CALL SCHEDULED FOR MAY 7, 2009 2
For microscopy...
... An easy-to-use solution that enables fully automated ... 400 Hybridization Station has been designed to ... the throughput necessary to perform a wide ... performed in the range 485C; denaturations of ...
... microarray slide processing offering reproducibility, reliability ... to miniaturization, automation and massive parallel ... tool with many applications in both ... range from gene expression profiling, gene ...
... Eppendorf Thermomixer R offers maximum application ... shaking, heating, and cooling. Its active ... application and temperature control ranges. Five ... 24 micro test tubes, are available ...
Biology Products: