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Cholesterol rafts deliver drugs inside cancer cells
Date:4/2/2013

earlier experiments that rafts create more delivery of payload materials into cancer cells, but there was always the outside chance that the benefit was due simply to higher levels of cholesterol and not to the action of the rafts, themselves," Anchordoquy says.

The current study found an elegant fix: with longer tails on lipid molecules, particles will form rafts at lower cholesterol concentrations. The team used long-tailed lipids to form their particles, allowing them to keep cholesterol concentration low while showing the same benefit in delivering genes into cancer cells. This demonstrates that it is indeed the raft that facilitates delivery.

"We've used these synthetic rafts to deliver a gene inside these cells that makes the cells fluoresce," Anchordoquy says. "That way we can see how much payload went in. But because we're talking particles and not just individual molecules, in the future we can send other cargo like microRNA's that can reprogram a cell's gene expression."

Anchordoquy is working with colleagues at the CU Cancer Center to match his delivery system with a potent payload, and welcomes collaboration outside the center as well.


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Contact: Garth Sundem
garth.sundem@ucdenver.edu
University of Colorado Denver
Source:Eurekalert

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