Navigation Links
Cholesterol necessary for brain development
Date:10/2/2009

[PRESS RELEASE, 2 October 2009] A derivative of cholesterol is necessary for the formation of brain cells, according to a study from the Swedish medical university Karolinska Institutet. The results, which are published in the journal Cell Stem Cell, can help scientists to cultivate dopamine-producing cells outside the body.

The study was led by Professor Ernest Arenas and demonstrates that the formation of dopamine-producing neurons during brain development in mice is dependent on the activation of a specific receptor in the brain by an oxidised form of cholesterol called oxysterol. Dopamine-producing nerve cells play an important part in many brain functions and processes, from motor skills to reward systems and dependency. They are also the type of cell that dies in Parkinson's disease.

The scientists have also shown that embryonic stem cells cultivated in the laboratory, form more dopamine-producing nerve cells if they are treated with oxidised cholesterol. The same treatment also reduced the tendency of the stem cells to show uncontrolled growth.

"Oxysterol contributes to a safer and better cultivation of dopamine-producing cells, which is a great advancement since it increases the possibility of developing new treatments for Parkinson's disease," says Professor Arenas.

It is hoped that one day it will be possible to replace dead cells in the brains of Parkinson's patients with transplanted cultivated dopamine-producing cells. Such cells can also be used to test new Parkinson's drugs.


'/>"/>

Contact: Press Officer Katarina Sternudd
katarina.sternudd@ki.se
46-852-483-895
Karolinska Institutet
Source:Eurekalert

Page: 1

Related biology news :

1. Cholesterol-busting bug with a taste for waste
2. Lowering your cholesterol may decrease your risk of cancer
3. Hypertension and cholesterol medications present in water released into the St. Lawrence River
4. New genes present drug targets for managing cholesterol and glucose levels
5. Researchers learn that some good cholesterol isnt good enough
6. A scientific breakthrough on the control of the bad cholesterol
7. MSU researcher studies ties between cholesterol drugs, muscle problems
8. Penn biophysicists create new model for protein-cholesterol interactions in brain and muscle tissue
9. Cholesterol-lowering drugs and the effect on muscle repair and regeneration
10. Mitochondrial cholesterol makes response to chemotherapy difficult in hepatic cancer
11. Niacins role in maintaining good cholesterol
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/17/2017)... NXT-ID, Inc. (NASDAQ: NXTD ) ("NXT-ID" or the "Company"), ... Report on Form 10-K on Thursday April 13, 2017 with the ... The ... section of the Company,s website at http://www.nxt-id.com  under "SEC Filings," ... 2016 Year Highlights: Acquisition of ...
(Date:4/11/2017)... , April 11, 2017 Crossmatch®, a ... authentication solutions, today announced that it has been ... Research Projects Activity (IARPA) to develop next-generation Presentation ... "Innovation has been a driving force ... program will allow us to innovate and develop ...
(Date:4/11/2017)... MELBOURNE, Florida , April 11, 2017 ... "Company"), a security technology company, announces the appointment of independent ... John Bendheim to its Board of Directors, furthering the ... ... behalf of NXT-ID, we look forward to their guidance and ...
Breaking Biology News(10 mins):
(Date:8/11/2017)... Glendale, Calif. (PRWEB) , ... August 11, 2017 , ... ... a plant collagen-based formulation unlocking collagen like never before. , Collagen is the ... many firsts to market with Liquid Collagen™, which include: , ...
(Date:8/10/2017)... ... August 09, 2017 , ... ... the agriculture industry reach its ideal customers with the right message. Their effective, ... “As a Midwest company, we realize how crucial the agriculture industry is,” said ...
(Date:8/10/2017)... ... August 09, 2017 , ... The era ... clinic is here. The team at Capricor Therapeutics, Inc. utilized a cardiosphere-derived stem-like ... studies. , Dr. Travis Antes, head of analytical development at Capricor Therapeutics ...
(Date:8/10/2017)... ... August 09, 2017 , ... Okyanos Center for Regenerative Medicine has announced its ... Hotel in Freeport, Grand Bahama on September 27, 2017. This daytime event is free ... from the Ministry of Health’s National Stem Cell Ethics Committee (NSCEC) and regulations laid ...
Breaking Biology Technology: