Navigation Links
Cholesterol metabolism links early- and late-onset Alzheimer's disease
Date:10/4/2007

Oct. 4, 2007 -- Although the causes of Alzheimer's disease are not completely understood, amyloid-beta (A-beta) is widely considered a likely culprit the "sticky" protein clumps into plaques thought to harm brain cells.

But now researchers at Washington University School of Medicine in St. Louis have uncovered evidence strengthening the case for another potential cause of Alzheimer's. The finding also represents the first time scientists have found a connection between early- and late-onset Alzheimer's.

In a study published in the Oct. 4, 2007 issue of the journal Neuron, the scientists report that when A-beta is made, a small bit of protein is also released that can regulate cholesterol levels in the brain. The discovery adds weight to the less prominent theory that abnormal brain cholesterol metabolism plays a role in the mental decline seen in Alzheimer's patients.

"Our research links two major determinants for early- and late-onset Alzheimer's disease," says senior author Guojun Bu, Ph.D., professor of pediatrics and of cell biology and physiology. "And we've shown that the process that links them is implicated in brain cholesterol metabolism."

The report follows closely on another study reporting that statins, widely prescribed cholesterol-lowering drugs, could prevent certain neural changes that signal the progression of Alzheimer's disease. Additional earlier studies support the idea that statins could benefit Alzheimer's patients; however, other studies have found no such protective effect from statins.

"The studies of statins and Alzheimer's have generated quite a bit of controversy," Bu says. "Those that show positive effects from statins seem to suggest that high cholesterol could increase the risk of Alzheimer's disease. But other evidence contradicts this idea."

In fact, the brain needs a high level of cholesterol, according to Bu. "The brain represents only about 2 percent of your body weight, but actually has abou
'/>"/>

Contact: Gwen Ericson
ericsong@wustl.edu
314-286-0141
Washington University in St. Louis
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Insight into natural cholesterol control suggests novel cholesterol-lowering therapy
2. Babys genes affect moms cholesterol levels
3. Cholesterol gets thumbs up for role in digit development
4. Nearly half of people who need cholesterol treatment dont get it
5. Gene transfer using mutant form of good cholesterol cuts vascular plaque and inflammation
6. New study finds chocolate chip cookies lower cholesterol
7. Primitive yeast yields secrets of human cholesterol and drug metabolism
8. Pistachios lower cholesterol, provide antioxidants
9. Opposing fat metabolism pathways triggered by a single gene
10. Attacks of King George IIIs madness linked to key metabolism molecule
11. Computational model simulates AZT metabolism in mitochondria
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/17/2014)... , Dec. 16, 2014 Valencell, a leader in ... biometric technology to industry leaders such as Intel, Jabra, ... validated, biometric wearable products. These products will be showcased ... Las Vegas . "Our ...
(Date:12/11/2014)... 09, 2014 Research and Markets , ... ) has announced the addition of the "Biometrics ... offering. One major trend emerging in ... in technology, it is important to upgrade biometric solutions ...
(Date:12/10/2014)... YORK , Dec. 8, 2014 You,ve been here before: ... can,t remember your password, site key or the answer to your ... teacher? Today, Hoyos Labs , a digital ... put an end to the frustration that comes with usernames, passwords ...
Breaking Biology News(10 mins):Valencell PerformTek Biometrics Power the Most Accurate Wearables at CES 2015 2Biometrics Market in the APAC Region 2015-2019: Key Vendors are 3M Cogent, NEC, Safran and Suprema 2The Password is Finally Dead: Launch of 1U Mobile App Eliminates Need for All Usernames and Passwords 2The Password is Finally Dead: Launch of 1U Mobile App Eliminates Need for All Usernames and Passwords 3
... State College currently advises a team of researchers ... garb rather than the lab coats and khakis ... composed of such apparently iconoclastic researchers? Because all ... Corrections Center, a medium security prison in Littlerock, ...
... National Laboratories engineer, and Bruce Osborn, chief operating officer ... Popular Mechanics magazine Breakthrough Innovator Award Oct. 15 during ... City. Sponsored by Bristol-Myers Squibb, the Breakthrough Awards ... personalities behind them. The joint Sandia/SES award is among ...
... new UC Davis study says that people trying to ... more naturally. "Human beings tend to think in ... more irregular," said UC Davis,postdoctoral researcher Matthew Holland, the ... may actually do less good,for natural communities than designs ...
Cached Biology News:Inmates conduct ecological research on slow-growing mosses 2Sandia, SES win Popular Mechanics Breakthrough Innovator Award 2
(Date:12/24/2014)... “Preparative & Process Chromatography Market by Instrument ... Buffers, Valves, Guages, Seals), Accessories, Services, End User ... 2019” provides a detailed overview of the major ... strategies impacting the preparative and process chromatography market ...
(Date:12/24/2014)... 2014 Earlier this year in a June ... the Adult Stem Cell Technology Center, LLC ( ASCTC ) ... property of adult tissue stem cells. His title “Asymmetric ... for the Future,” embodied the essence of his message to ...
(Date:12/24/2014)... MD (PRWEB) December 23, 2014 On ... H.R. 83, the Omnibus and Continuing Resolution Appropriations Act ... a condition eligible to receive funding through the Congressionally ... of Defense (DoD). The Hydrocephalus Association (HA), working in ...
(Date:12/24/2014)... 23, 2014 The report provides ... definition, classification, application and industry overview. This report ... cost structure. Production is separated by regions, technology ... materials, equipment, downstream client survey, marketing channels, industry ...
Breaking Biology Technology:Preparative and Process Chromatography Market is expected to reach $9 billion by 2019 - New Report by Marketsandmarkets 2Preparative and Process Chromatography Market is expected to reach $9 billion by 2019 - New Report by Marketsandmarkets 3Preparative and Process Chromatography Market is expected to reach $9 billion by 2019 - New Report by Marketsandmarkets 4Adult Stem Cell Technology Center, LLC’s Director Sherley's Address on What’s Holding Back Regenerative Medicine Featured on Omics Group Website 2Adult Stem Cell Technology Center, LLC’s Director Sherley's Address on What’s Holding Back Regenerative Medicine Featured on Omics Group Website 3Adult Stem Cell Technology Center, LLC’s Director Sherley's Address on What’s Holding Back Regenerative Medicine Featured on Omics Group Website 4Rare Brain Condition Now Eligible for Department of Defense Research Dollars 2Worldwide Methyl Mercaptan Market 2015-2020 Forecasts on Development & Trends Now Available at ReportsnReports.com 2
... GERMANTOWN, Maryland and HILDEN, Germany , ... Frankfurt , Prime Standard:,QIA) today announced that it ... Quality (ifp), pursuant to which QIAGEN has acquired all ... Berlin -based specialized,laboratory center for food analysis. The ...
... May 25 /PRNewswire-FirstCall/ - Mr. Richard Gilbertson reports: , ... IGEN Networks Corp. is pleased ... of the Board of Directors and will represent IGEN as CEO of ... Canadian corporation and is proceeding to acquire broadband licenses in Alberta ...
... label for Antarctic krill fishery is misleading , ... WASHINGTON , May 25 The Pew Environment Group today criticized the ... the false impression that the entire fishery for Antarctic krill is sustainable when in ... , Seafood with the ...
Cached Biology Technology:QIAGEN Acquires Comprehensive Portfolio of Molecular Food Safety Tests 2QIAGEN Acquires Comprehensive Portfolio of Molecular Food Safety Tests 3QIAGEN Acquires Comprehensive Portfolio of Molecular Food Safety Tests 4QIAGEN Acquires Comprehensive Portfolio of Molecular Food Safety Tests 5QIAGEN Acquires Comprehensive Portfolio of Molecular Food Safety Tests 6QIAGEN Acquires Comprehensive Portfolio of Molecular Food Safety Tests 7IGEN Networks Corp. announces new Board member and the cancellation of three million shares for return to treasury 2Pew Faults Marine Stewardship Council's Decision 2Pew Faults Marine Stewardship Council's Decision 3
The LIC Duet™ Mini Adaptor encodes a T7 promoter, lac operator, ribosome binding site (rbs), and an ATG translation initation codon. This adaptor is designed for expression of a target protei...
... these culture chambers produce cell yields in ... range and are useful alternatives to multiple ... mechanical • strength and structural integrity • ... Certified nonpyrogenic and sterilized by gamma irradiation, ...
ABgene® supplies a 94kDa ultra-pure recombinant thermostable DNA polymerase obtained by high level expression of the Taq DNA polymerase gene in E. coli....
...
Biology Products: