Navigation Links
Cholesterol helps regulate key signaling proteins in the cell
Date:12/19/2012

Cholesterol plays a key role in regulating proteins involved in cell signaling and may be important to many other cell processes, an international team of researchers has found.

The results of their study are reported in the journal Nature Communications.

Cholesterol's role in heart disease has given it a bad reputation. But inside the thin membrane of a cell, the tight regulation of cholesterol at high levels (30 to 40 percent) suggests that it plays an important role in cellular processes, says Wonhwa Cho, professor of chemistry at the University of Illinois at Chicago and principal investigator on the study.

Cho and colleagues had previously found evidence that cholesterol was directly interacting with many proteins found in the interior of the cell. The interaction seemed necessary for the proper functioning of these proteins.

"This was quite a surprising finding," said Cho, because cholesterol resides within the membrane, sandwiched between its inner and outer face. Cell biologists had thought it could only interact with other biomolecules within the membrane.

In the new study, Cho and his colleagues showed how cholesterol interacts with a scaffolding protein, one of a class of proteins that plays an important role in cell signaling. The researchers showed that cholesterol binds to a region on the protein molecule where one of its signaling partners also binds -- and that disrupting cholesterol binding to the protein makes it unable to activate its partner.

The researchers describe in detail how the protein hooks onto and reaches inside the membrane to find and bind cholesterol.

Cho believes that this strategy for interacting with cholesterol may be used by many interior cellular proteins and offers an insight into what is known about the importance of cholesterol to well-functioning cells.

Much of the existing data on the cholesterol-related regulation of cellular processes ha
'/>"/>

Contact: Jeanne Galatzer-Levy
jgala@uic.edu
312-996-1583
University of Illinois at Chicago
Source:Eurekalert

Page: 1 2

Related biology news :

1. Host cholesterol secretion likely to influence gut microbiota
2. Vitamin D supplements do not improve cholesterol as previous research suggested
3. Zebrafish research shows how dietary fat regulates cholesterol absorption
4. Some HDL, or good cholesterol, may not protect against heart disease
5. Study finds cancer-fighting goodness in cholesterol
6. New research helps predict susceptibility to Burkitt lymphoma
7. X-ray laser helps slay parasite that causes sleeping sickness
8. Fish oil helps heal bed sores of the critically ill
9. Losing protein helps heart recover, say Temple scientists
10. Fossil study helps pinpoint extinction risks for ocean animals
11. Bacterias key innovation helps understand evolution
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/24/2014)... NEW YORK , Dec. 23, 2014  Since its ... has helped thousands of people to eliminate the pain ... replacing the antiquated system with their own biometrics fused ... to remember usernames and passwords, Hoyos Labs , ... identity, announced today that it is offering the app ...
(Date:12/22/2014)... SHELTON, Conn. , Dec. 22, 2014  NXT-ID, ... or the "Company"), a biometric authentication company focused on ... famous pickpocket, entertainer and security consultant, Apollo Robbins ... Wocket™ biometric smart wallet.  Apollo ... 6th and 7 th , 2015, demonstrating some of ...
(Date:12/22/2014)... Dec. 22, 2014 Research and Markets ... the addition of the "The Global ... their offering. ... an overview of the global digital media ... control and monitor piracy by securely and ...
Breaking Biology News(10 mins):1U Offers Best Solution to the Username / Password Dilemma: For FREE! 21U Offers Best Solution to the Username / Password Dilemma: For FREE! 3NXT-ID Hires Master Pickpocket and Security Consultant Apollo Robbins for Wocket Smart Wallet CES 2015 Debut 2NXT-ID Hires Master Pickpocket and Security Consultant Apollo Robbins for Wocket Smart Wallet CES 2015 Debut 3NXT-ID Hires Master Pickpocket and Security Consultant Apollo Robbins for Wocket Smart Wallet CES 2015 Debut 4The Global Watermarking and Fingerprinting Markets 2
... Atlantis rockets into space later this week, it will ... study how their genetic responses and their ability to ... part of the STS-115 space shuttle mission scheduled for ... Salmonella typhimurium, Pseudomonas aeruginosa and Candida albicans -- that ...
... Virginia Health System have shown for the first time ... muscle cells can reverse myotonic dystrophy, the most common ... 40,000 people in the United States have myotonic muscular ... wasting of the muscles, irregular heartbeat, cataracts and insulin ...
... the Rubeho Mountains in Tanzania revealed over 160 ... eleven endemic species--according to an article published in ... findings elevate the importance of protecting this biologically-rich ... range from destructive activities underway such as clear-cutting ...
Cached Biology News:Microscopic passengers to hitch ride on space shuttle 2Microscopic passengers to hitch ride on space shuttle 3Toxic molecule may cause most common type of muscular dystrophy 2First surveys of Tanzanian mountains reveal 160+ animal species, including new & endemic 2
(Date:12/25/2014)... The report “Service Quality Management ... Product Type & Provider Type - Global ... and segments the market with an in-depth ... Browse 152 market data tables, 19 figures ... on “Service Quality Management (SQM) and Telco ...
(Date:12/24/2014)... SILVER SPRING, Md. , Dec. 24, 2014 ... ) announced today that Medtronic, Inc. (NYSE: ... application to the U.S. Food and Drug Administration ... II implantable drug infusion system (including a ... Remodulin ® (treprostinil) Injection delivered intravenously to ...
(Date:12/24/2014)... NEW YORK , Dec. 24, 2014 /PRNewswire/ ... company advancing patient care in critical areas, announced the ... of common stock, and warrants to purchase up to ... offering price of $4.00 per share and $.01 per ... of $5.00, are exercisable immediately, and expire 5 years ...
(Date:12/24/2014)... , Dec. 24, 2014  Vermillion, Inc. (Nasdaq: ... gynecologic disease, announced today that the Company closed ... Oracle Investment Management, Jack W. Schuler , ... proceeds were $10.5 million, before offering expenses.  The ... general corporate purposes. Under the terms ...
Breaking Biology Technology:Service Quality Management Market worth $2.1 Billion & Telco Customer Experience Management Market worth $2.3 Billion by 2019 – New Report by MarketsandMarkets 2Service Quality Management Market worth $2.1 Billion & Telco Customer Experience Management Market worth $2.3 Billion by 2019 – New Report by MarketsandMarkets 3Service Quality Management Market worth $2.1 Billion & Telco Customer Experience Management Market worth $2.3 Billion by 2019 – New Report by MarketsandMarkets 4United Therapeutics Announces Submission Of Pre-Market Approval Application For Implantable Drug Infusion System To Deliver Remodulin 2United Therapeutics Announces Submission Of Pre-Market Approval Application For Implantable Drug Infusion System To Deliver Remodulin 3United Therapeutics Announces Submission Of Pre-Market Approval Application For Implantable Drug Infusion System To Deliver Remodulin 4PlasmaTech Biopharmaceuticals, Inc. Announces Closing of Public Offering 2PlasmaTech Biopharmaceuticals, Inc. Announces Closing of Public Offering 3Vermillion Announces Closing of Equity Financing 2Vermillion Announces Closing of Equity Financing 3
... PRA, a leading Clinical Research Organization, continues our expansion ... of an office in Singapore. The office will serve ... strengthening the quality and timeliness of our deliverables to ... the heart of the city-state, will provide monitoring, project ...
... PARK, Calif., Feb. 23, 2012 Telome Health, Inc.™, ... telomere biology in human health, has announced that co-founder and ... Year by Silicon Valley Business Journal. ... award, especially coming from the heart of innovation, Silicon Valley, ...
... Calif., Feb. 21, 2012 Keck Graduate Institute (KGI) ... (CGS) and the Alfred P. Sloan Foundation to administer ... part of establishing and maintaining high quality standards for ... honored to be selected and we look forward to ...
Cached Biology Technology:PRA Opens Office in Singapore 2Telome Health Co-founder and Nobel Laureate Elizabeth Blackburn Awarded Innovator of the Year 2KGI Selected to Administer PSM Affiliation Process 2
...
... The ideal modular cleanroom for biological ... that require cleanliness (to Class 10/ISO ... precision-joined to create ultra-smooth surfaces that ... disinfect. One-inch radius corners simplify cleaning. ...
This free-standing work station safely ventilates fumes upwards, away from the work surface. Optional Exhaust Purification System features bonded charcoal filters that remove organic chemical vapors ...
... Analysis Note: Protein determined by ... 3.2 M (NH 4 ) ... 7.0 Preparation Note: Affinity purified ... suspension • Additives: MgCl 2 ...
Biology Products: