Navigation Links
Cholera strain evolves new mechanism for causing disease
Date:12/9/2010

New clinical strains of cholera appear to have evolved a distinctly different mechanism to cause the same disease according to research published in the current issue of the online journal mBio.

Vibrio cholerae is the causative agent for the diarrheal disease cholera. While there are more than 200 different serogroups only the O1 and the O139 strains have been known to cause epidemic and pandemic outbreaks of disease, using a toxin-coregulated pilus (TCP) and cholera toxin (CT), which other strains lack.

"While non-O1, non-O139 strains have caused sporadic disease globally, the virulence mechanisms are not fully understood, since most of these strains lack TCP and CT," say the researchers from Harvard Medical School and the International Center for Diarrhoeal Research in Dhaka, Bangladesh.

The researchers studied a newly identified non-O1, non-O139 strain of the bacteria called AM-19226. Using comparative genomics, they investigated how this new strain causes diarrhea.

Many pathogenic bacteria require something called a type III secretion system (T3SS) in order to cause disease. In previous studies, the researchers discovered a T3SS and identified a protein (vopF) that they believe could be involved in causing disease.

In the current study they identified an additional protein (vopE) and using mouse models show that AM-19226 requires T3SS to cause diarrhea and that both vopE and vopF contribute to the disease.

"With the discovery of the T3SS in V. cholerae and its role in the virulence of non-O1 and non-O139 strains, it is astonishing to observe how this bacterium has evolved two independent pathogenic mechanisms to cause similar disease," say the researchers.


'/>"/>

Contact: Jim Sliwa
jsliwa@asmusa.org
202-942-9297
American Society for Microbiology
Source:Eurekalert

Page: 1

Related biology news :

1. Polarized light guides cholera-carrying midges that contaminate water supplies
2. UCF professors vaccine could be lethal weapon against malaria, cholera
3. Dartmouth researchers describe how the cholera bacteria becomes infectious
4. Sari cloth a simple sustainable protector from cholera
5. Rensselaer professor uncovers mysterious workings of cholera bacteria
6. Researchers recreate SARS virus, open door for potential defenses against future strains
7. Strained quantum dots show new optical properties
8. Knee injuries may start with strain on the brain, not the muscles
9. Novel bacterial strains clear algal toxins from drinking water
10. Genomes of 2 popular research strains of E. coli sequenced
11. New, virulent strain of MRSA poses renewed antibiotic resistance concerns
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/11/2016)... , March 11, 2016 http://www.apimages.com ) - ... reference: Picture is available at AP Images ( http://www.apimages.com ) - ... will be used to produce the new refugee identity cards. DERMALOG ... innovations, at CeBIT in Hanover next week.   ... DERMALOG will be used to produce the new refugee identity cards. ...
(Date:3/9/2016)... , March 9, 2016 ... identified that more than 23,000 public service employees either ... been receiving their salary unlawfully.    --> ... government identified that more than 23,000 public service employees ... had been receiving their salary unlawfully.    --> ...
(Date:3/3/2016)... England and DE SOTO, Kansas ... , U.S.-based Stroke Detection Plus® to offer Oncimmune,s ... risk assessment and early detection of lung cancer ... large employers, unions and individuals. --> Early ... unions and individuals. --> Oncimmune, a leader ...
Breaking Biology News(10 mins):
(Date:4/26/2016)... ... , ... The European Patent Office (EPO) today announced that ... the European Inventor Award 2016 in the category "Non-European countries." The winners of the ... in Lisbon on June 9th. , The human capacity to walk with fluidity is ...
(Date:4/26/2016)... CA (PRWEB) , ... April 26, 2016 , ... Mr. ... for Adecco RPO, signing the first multi-million dollar, multi-year managed services contract in the ... to have Michael join our leadership team,” said John Younger, founder of Accolo. ...
(Date:4/26/2016)... ... April 26, 2016 , ... BioFactura, Inc ., a biopharmaceutical research ... financing. Healthy investor interest drove significant oversubscription of the original $1.5M target. ... biosimilars, to the advanced preclinical stages. , Chief Executive Officer and President, Darryl ...
(Date:4/26/2016)... BUDAPEST, Hungary , VIENNA ... 26, 2016 The prize ... and the resulting revolutionary innovations that will benefit ... (Logo: http://photos.prnewswire.com/prnh/20160210/331945LOGO ) , ... developing novel proprietary trend setting products in the ...
Breaking Biology Technology: