Navigation Links
Chlorophylls effective against aflatoxin
Date:12/29/2009

tems, an OSU spinoff company that hopes to continue work with natural products grown in Oregon, including pure chlorophylls.

"The technology is not particularly difficult," she added. "It's just a novel approach to evaluate toxin exposure in humans."

In their study, Jubert and her colleagues gave very low doses of aflatoxin labeled with carbon-14 isotopes as a tracer to four human volunteers. They then gave the volunteers the same doses of aflatoxin along with doses of either chlorophyll or chlorophyllin, which previously had been shown to reduce carcinogen bioavailability in trout and rats. Using an accelerator mass spectrometer, they measured the rate of aflaxtoxin bioavailability. This technique is extremely sensitive, the researchers say, allowing measurement of minute amounts of any labeled compound.

Their research revealed rapid absorption of aflatoxin, which was significantly limited after the chlorophyll and chlorophyllin treatments.

"The beauty of this kind of 'Phase 0' study is the use of ultra-sensitive technology and 'microdoses' of environmental carcinogens to study toxicokinetics within the human body," said John Mata, an OSU pharmacologist and second author on the study. "These measurements can be important because they allow us to better design future studies to understand the effects of dietary constituents on cancer risk.

"In this case, clearly the results merit further study," Mata added. "We showed that aflatoxin is absorbed quite rapidly and that chlorophyll and chlorophyllin have an ameliorating effect, preventing the toxin from getting into the bloodstream. Further studies can more precisely explore the interactions, as well as dosage levels."

Jubert and Mata also have tested the feasibility of using similar technology on human exposure to other toxins, including smokers who ingest carcinogens through cigarette smoke.

Mata, a professor in OSU's College of Veterinary Medicine, is a
'/>"/>

Contact: John Mata
john.mata@oregonstate.edu
541-737-6874
Oregon State University
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Gamma globulin effective in treating eye infections caused by adenoviruses
2. UC health news: molecular pathway may predict chemotherapy effectiveness
3. Socioeconomic position associated with effectiveness of HIV drugs
4. New nanoparticle vaccine is more effective but less expensive
5. MIT model could improve some drugs effectiveness
6. Trial seeks genetic fingerprint for predicting drug effectiveness
7. New hope for horse lovers as effective control for killer ragwort is proposed
8. Quantitative PET imaging finds early determination of effectiveness of cancer treatment
9. Gene, stem cell therapy only needs to be 50 percent effective to create a healthy heart
10. Tamiflu effective for treatment and prevention of influenza in children 1 year and older
11. Safe and effective therapy discovered for patients with protein-losing enteropathy
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/25/2015)... 25, 2015 According to ... (Swipe & Area), Technology, Material (Optical Prism, Piezoelectric, ... Security & Others) & Geography - Global Forecast ... said market is expected to reach $14,500.07 Million ... Browse 76 market Tables and 109 ...
(Date:6/25/2015)... , June 25, 2015  TAKE Solutions Ltd., ... patent by the United States Patent and Trademark Office ... This process leverages TAKE Solutions, Clinical Accelerators to reduce ... 50% (when compared to standardization without the accelerators), thus ... At the heart of the ...
(Date:6/24/2015)... 24, 2015 This report provides market analysis ... six years. It contains an analysis of the drivers, ... their impact from the short, medium, and long term ... industry, market, and technology trends that currently, prevail in ... concerned authorities to efficiently manage the increasing marine traffic ...
Breaking Biology News(10 mins):Fingerprint Sensors Market Worth $14,500.07 Million by 2020 2Fingerprint Sensors Market Worth $14,500.07 Million by 2020 3Fingerprint Sensors Market Worth $14,500.07 Million by 2020 4TAKE Solutions Awarded Patent By USPTO 2Automatic Identification System Market by Class, by Platform, by Application and by Geography - Global Forecasts & Analysis to 2014 - 2020 2
... new species of bird in Gabon, Africa, that was, ... were published in the international science journal Zootaxa today, ... (Stiphrornis pyrrholaemus) was named by the scientists for its ... inches in length and average 18 grams in weight. ...
... A new systematic analysis of the relationship between ... of trends in cancer gene expression. The research, ... Genome Biology, describes how cancers can be divided ... Isaac S Kohane from Children,s Hospital Boston ...
... 14 L-1 Identity,Solutions, Inc. (NYSE: ID ), ... that it closed its tender offer for all of ... and completed its,acquisition of Digimarc,s ID systems business., ... expired at,5:00 p.m. (ET) on August 13, 2008. Through ...
Cached Biology News:Smithsonian scientists discover new bird species 2Smithsonian scientists discover new bird species 3Cancer signatures uncovered 2L-1 Identity Solutions Completes Acquisition of the ID Systems Business from Digimarc Corporation 2L-1 Identity Solutions Completes Acquisition of the ID Systems Business from Digimarc Corporation 3
(Date:7/7/2015)... (PRWEB) , ... July 07, 2015 , ... 4MD ... Business Women’s Association, offering an exclusive scholarship opportunity for women across the country to ... committed individual as they continue their education,” said Rochelle Schwartz, Founder of 4MD Medical ...
(Date:7/7/2015)... 2015  In the farthest reaches of the Amazon ... tribe came together in a quest to save their ... held in May in a remote village on the ... , concluded over two years work and culminated in ... written by an Amazonian tribe. The 500-page repository details ...
(Date:7/7/2015)... , July 7, 2015  SME,s Advanced Manufacturing ... third-annual "30 Under 30" issue, celebrating young men and ... The July issue of Manufacturing ... professionals and students for their accomplishments. Among the standouts: ... U.S. Air Force on optimizing the topology of flapping ...
(Date:7/7/2015)... (PRWEB) , ... July 07, 2015 , ... uBiome, the ... up to $100,000 of microbiome sampling kits and full 16S laboratory analysis. The goal ... well-being. The winner will also have access to their own dashboard, enabling them to ...
Breaking Biology Technology:4MD Medical Announces $2,000 Scholarship Opportunity in Conjunction with American Business Women’s Association (ABWA) 24MD Medical Announces $2,000 Scholarship Opportunity in Conjunction with American Business Women’s Association (ABWA) 3Amazonian Tribe Creates First Encyclopedia of Indigenous Medicine 2Amazonian Tribe Creates First Encyclopedia of Indigenous Medicine 3Amazonian Tribe Creates First Encyclopedia of Indigenous Medicine 4SME's Advanced Manufacturing Media Recognizes "30 Under 30" Future Leaders of Manufacturing 2SME's Advanced Manufacturing Media Recognizes "30 Under 30" Future Leaders of Manufacturing 3SME's Advanced Manufacturing Media Recognizes "30 Under 30" Future Leaders of Manufacturing 4SME's Advanced Manufacturing Media Recognizes "30 Under 30" Future Leaders of Manufacturing 5uBiome to Award Grant of up to $100k for Groundbreaking Microbiome Research 2uBiome to Award Grant of up to $100k for Groundbreaking Microbiome Research 3
... March 28, 2012  Regado Biosciences, Inc., a privately held ... control agents, announced that David J. Mazzo, PhD, President ... 11th Annual Healthcare Conference at 10 a.m. EDT on ... in New York City. The presentation will ...
... little dry ice and a simple industrial process cheaply ... Case Western Reserve University report. Graphene, which ... in pencils, has been hailed as the most important ... than copper, heat better than any material known, are ...
... March 26, 2012 Aviir, a biotechnology company dedicated ... tests and Guard A Heart, a non-profit foundation committed ... Storyland, a Red Carpet Charity Extravaganza in Hollywood on ... whimsical Dr. Seuss theme, as homage to the children ...
Cached Biology Technology:Regado Biosciences, Inc. to Present at Needham & Company's 11th Annual Healthcare Conference in New York, NY 2Regado Biosciences, Inc. to Present at Needham & Company's 11th Annual Healthcare Conference in New York, NY 3Simple, cheap way to mass-produce graphene nanosheets 2Aviir Diagnostics Laboratory in Collaboration with Cause;ology Sponsors "Storyland," a Red Carpet Charity Extravaganza in Hollywood 2Aviir Diagnostics Laboratory in Collaboration with Cause;ology Sponsors "Storyland," a Red Carpet Charity Extravaganza in Hollywood 3
... Methylated Protein Molecular Weight Markers, 37 kBq, ... molecular weight determination of the sample on ... monitoring of band migration in the gel ... the [14C] version without Rainbow-labeling is 0.37-3.7 ...
NM522 contains an F episome, which is required for production of ssDNA and for blue/white color selection. To maintain the F, NM522 should be grown on minimal (M-9) medium....
... Blunt TOPO PCR Cloning ... designed for cloning and ... PCR products. The pCR4Blunt-TOPO ... Cloning and greater than ...
... 1 EA. Ultrospec 6300 pro ... of the Pharmacopoeia in terms of instrument ... of being able to be used for ... and excellent scanning capability., *Press to read ...
Biology Products: