Navigation Links
Children's Research Institute finds key to identifying, enriching mesenchymal stem cells
Date:6/20/2014

DALLAS June 20, 2014 The Children's Medical Center Research Institute at UT Southwestern (CRI) has identified a biomarker that enables researchers to accurately characterize the properties and function of mesenchymal stem cells (MSCs) in the body. MSCs are the focus of nearly 200 active clinical trials registered with the National Institutes of Health, targeting conditions such as bone fractures, cartilage injury, degenerative disc disease, and osteoarthritis.

The finding, published in the journal Cell Stem Cell on June 19, significantly advances the field of MSC biology, and if the same biomarker identified in CRI's studies with mice works in humans, the outlook for clinical trials that use MSCs will be improved by the ability to better identify and characterize the relevant cells.

"There has been an increasing amount of clinical interest in MSCs, but advances have been slow because researchers to date have been unable to identify MSCs and study their normal physiological function in the body," said Dr. Sean Morrison, Director of the Children's Research Institute, Professor of Pediatrics at UT Southwestern Medical Center, and a Howard Hughes Medical Institute Investigator. "We found that a protein known as leptin receptor can serve as a biomarker to accurately identify MSCs in adult bone marrow in vivo, and that those MSCs are the primary source of new bone formation and bone repair after injury."

In the course of their investigation, the CRI researchers found that leptin receptor-positive MSCs are also the main source of factors that promote the maintenance of blood-forming stem cells in the bone marrow.

"Unfortunately, many clinical trials that are testing potential therapies using MSCs have been hampered by the use of poorly characterized and impure collections of cultured cells," said Dr. Morrison, senior author of the study and holder of the Mary McDermott Cook Chair in Pediatric Genetics at UT Southwestern. "If this finding is duplicated in our studies with human MSCs, then it will improve the characterization of MSCs that are used clinically and could increase the probability of success for well-designed clinical trials using MSCs."


'/>"/>

Contact: Mark Lane
mark.lane@utsouthwestern.edu
214-648-3404
UT Southwestern Medical Center
Source:Eurekalert  

Related biology news :

1. New research reveals that emperor penguins are more willing to relocate
2. Damon Runyon, Sohn Conference Foundations name 3 new pediatric cancer research fellows
3. Researchers identify mitochondrial mutation linked to congenital myasthenic syndrome
4. Researcher discovers ovarian cancer treatment
5. Researchers develop genetic control mechanism for major livestock pest
6. DOE awards $100 million for innovative energy research
7. UC Riverside to lead new Energy Frontier Research Center project
8. Portable brain-mapping device allows UT Arlington researchers to see where memory fails
9. Scripps Research Institute scientists reveal molecular yin-yang of blood vessel growth
10. NIH and NSF collaborate to accelerate biomedical research innovations into the marketplace
11. NJIT researchers probe links between vision problems and cognition in a pioneering study
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Children's Research Institute finds key to identifying, enriching mesenchymal stem cells
(Date:2/16/2017)... 2017  Genos, a community for personal genetic ... received Laboratory Accreditation from the College of American ... laboratories that meet stringent requirements around quality, accuracy ... "Genos is committed to maintaining the ... honored to be receiving CAP accreditation," said ...
(Date:2/13/2017)... Former 9/11 Commission border counsel and Special ... Kephart of Identity Strategy Partners, LLP, today releases ... "Executive Order: Protecting the Nation From Foreign Terrorist Entry ... "As President Trump,s ,Travel Ban, Executive Order gains more ... the travel ban, it is important that our national ...
(Date:2/8/2017)... 2017 About Voice Recognition Biometrics Voice recognition ... against a stored voiceprint template. Acoustic features of ... tone are compared to distinguish between individual voices. ... most PCs already have a microphone and can ... biometrics are most likely to be deployed in ...
Breaking Biology News(10 mins):
(Date:2/27/2017)... Switzerland , February 27, 2017 A ... has indicated that researchers using animals in their research treat them ... from 26 countries, and detailed analysis of the results indicates that ... Europe to put into practice the principles of the ... ...
(Date:2/27/2017)... REDWOOD CITY, Calif. , Feb. 27, 2017 ... specialty pharmaceutical company focused on the development and ... moderate-to-severe acute pain, announced today the U.S. Food ... New Drug Application (NDA) under section 505(b)(2) for ... for the treatment of patients with moderate-to-severe acute ...
(Date:2/27/2017)... and HAMILTON, Bermuda ... (NASDAQ: ADXS ) and ... companies focused on developing cancer immunotherapies, today announced ... develop a novel cancer immunotherapy agent using Advaxis, ... SELLAS, patented WT1 targeted heteroclitic peptide antigen mixture ...
(Date:2/27/2017)... ... , ... In starting a program to hire college athletes, Catalyst ... for skill.” , In keeping with this philosophy, the Catalyst an Iowa premix manufacturer ... hoping to replicate the practice throughout the company. , “I’ve heard coaches talk on ...
Breaking Biology Technology: