Navigation Links
Children's National research links platelets to sepsis-related organ failure
Date:3/10/2009

WASHINGTON, DCScientists at Children's National Medical Center have identified a previously unknown contributor to organ failure in patients suffering from sepsis: platelets.

The finding, published in the American Journal of Respiratory and Critical Care Medicine, is the first time doctors have looked at and linked platelets to poor outcomes from this often fatal infection.

"Despite many medical advances over the last few decades, mortality rates for sepsis have not really improved," said Robert Freishtat, MD, MPH, of the Center for Genetic Medicine Research at Children's National Medical Center, who led the study. "But now that we know that platelets, which we previously believed to be merely 'innocent bystanders,' can actually contribute to the development of fatal complications from sepsis, we can use this knowledge to better gauge someone's risk of dying and to design new interventions."

Sepsis is the tenth leading cause of death in the United States. More than 40 percent of sepsis cases are fatal, and in most, the resulting organ failure, not the underlying infection, is the primary cause of death. Through gene and protein analyses in both septic mice and humans, scientists found that cases of severe sepsis featured a unique attribute: the genes within platelets were triggered to produce a protein known as granzyme B, which has been shown in previous studies to contribute to cell death as part of the body's immune response to cancer and viruses. During sepsis, platelets collect within major organs including the spleen, an important infection-fighting organ. As they collect and come into contact with the organ's cells, the granzyme B, if present, will cause the organ's cells to die. Previous research has shown that that this factor may be a major contributor to organ failure. Granzyme B was only detected in humans and mice with the most severe sepsis.

"Detection of granzyme B in platelets could be a huge step forward in battling sepsis," said Dr. Freishtat. "First, as a prognostic indicator, the protein's presence could show more aggressive treatments are needed right off the bat. Eventually, perhaps this knowledge will help us find a way to prevent organ failure by targeting interventions directly at the platelets and granzyme B production."


'/>"/>

Contact: Jennifer Leischer
jleische@cnmc.org
202-476-4500
Children's National Medical Center
Source:Eurekalert

Related biology news :

1. Lincoln Park Zoo scientists awarded National Institutes of Health grant
2. Story tips from the Departments of Energys Oak Ridge National Lab -- March 2009
3. Queens receives $9.1 million to establish National Center of Excellence in green chemistry
4. GUMC young scientist selected postdoc Fellow at National Space Biomedical Research Institute
5. New York, Florida schools win awards at national student competition
6. Wildlife Conservation Society helps Cameroon create new national park
7. Oxford Journals and the International Society for Computational Biology announce new partnership
8. Results of national nursery survey unveiled
9. Food counterfeiting, contamination outpace international regulatory systems
10. 150 years of Darwins landmark book spawns international conference
11. International study identifies gene variants associated with early heart attack
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/13/2017)... 2017 According to a new market research report ... Identity Administration, and Authorization), Service, Authentication Type, Deployment Mode, Vertical, and Region ... expected to grow from USD 14.30 Billion in 2017 to USD 31.75 ... ... MarketsandMarkets Logo ...
(Date:4/11/2017)... 2017 NXT-ID, Inc. (NASDAQ:   NXTD ... the appointment of independent Directors Mr. Robin D. Richards ... of Directors, furthering the company,s corporate governance and expertise. ... Gino Pereira , Chief ... to their guidance and benefiting from their considerable expertise as ...
(Date:4/5/2017)... , April 4, 2017 KEY FINDINGS ... anticipated to expand at a CAGR of 25.76% during ... diseases is the primary factor for the growth of ... report: https://www.reportbuyer.com/product/4807905/ MARKET INSIGHTS The global ... product, technology, application, and geography. The stem cell market ...
Breaking Biology News(10 mins):
(Date:5/23/2017)... (PRWEB) , ... May 23, 2017 , ... Vortex ... of “Label-free isolation of prostate circulating tumor cells using Vortex microfluidic technology ” ... result of a collaboration with Dr. Dino Di Carlo and Dr. Matthew Rettig at ...
(Date:5/23/2017)... ... May 23, 2017 , ... Kathy ... President of Clinical Operations. She brings years of expertise in establishing and leading ... professional foundation as a licensed occupational therapist, through a variety of leadership roles ...
(Date:5/23/2017)... ... May 23, 2017 , ... Cambridge Semantics , ... at this year’s Bio-IT World Conference and Expo in Boston May 23-25 ... 4.0 solution. The Anzo Smart Data Lake is also a finalist for the ...
(Date:5/22/2017)... ... May 22, 2017 , ... Stratevi, a boutique firm that partners with ... It has opened an office in downtown Boston at 745 Atlantic Ave. , ... important to generate evidence on the value they provide, not just to patients, but ...
Breaking Biology Technology: