Navigation Links
Children's Hospital scientists achieve repair of injured heart muscle in lab tests of stem cells
Date:11/25/2008

Researchers at Children's Hospital of Pittsburgh of UPMC have been able to effectively repair damaged heart muscle in an animal model using a novel population of stem cells they discovered that is derived from human skeletal muscle tissue.

The research team led by Johnny Huard, PhD transplanted stem cells purified from human muscle-derived blood vessels into the hearts of mice that had heart damage similar to that which would occur in people who had suffered a heart attack.

These transplanted myoendothelial cells repaired the injured muscle, stimulated the growth of new blood vessels in the heart and reduced scar tissue from the injury, thereby dramatically improving the function of the injured left ventricle, said Dr. Huard, director of the Stem Cell Research Center at Children's Hospital's John G. Rangos Sr. Research Center.

"This study confirms our belief that this novel population of stem cells discovered in our laboratory holds tremendous promise for the future of regenerative medicine. Specifically, myoendothelial cells show potential as a therapy for people who have suffered a myocardial infarction," said Dr. Huard, also the Henry J. Mankin Professor and vice chair for research in the Department of Orthopaedic Surgery, University of Pittsburgh School of Medicine. "The important benefit of our approach is that as a therapy, it would be an autologous transplant. This means that for a patient who suffers a heart attack, we would take a muscle biopsy from his or her muscle, isolate and purify the myoendothelial cells, and re-inject them into the injured heart muscle, thereby avoiding any risk of rejection by introducing foreign cells."

Results of this study are published in the Dec. 2 issue of the Journal of the American College of Cardiology.

The myoendothelial cells used in this study were more effective at repairing the injured cardiac muscle and reducing scar tissue than previous approaches that have
'/>"/>

Contact: Marc Lukasiak
marc.lukasiak@chp.edu
412-692-7919
Children's Hospital of Pittsburgh
Source:Eurekalert

Page: 1 2

Related biology news :

1. Rhode Island Hospital simulation center examines benefits and applications of medical simulation
2. First results from hospital trials testing
3. Field-hospital-on-a-chip project awarded to nanoengineer from UC San Diego
4. Brown University and Women & Infants Hospital expand national childrens study to Bristol County
5. Childrens Hospital researchers identify genetic mutation that may predict organ rejection
6. Rhode Island Hospital study finds link between obesity, type 2 diabetes and neurodegeneration
7. Childrens Memorial Hospital of Chicago receives a grant from BioMarin to support adult PKU outreach
8. Montreal Heart Institute and Mount Sinai Hospital researchers contribute to Crohns disease study
9. Childrens Hospital leads projects to develop nations first heart assist devices for young children
10. Clinical trial that may help patients breathe easier begins at Central DuPage Hospital
11. MRSA in hospital intensive care -- whats growing where?
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/8/2015)... June 8, 2015  The Secure Identity ... selection of Troy Potter of L-3 ... SIBA is a non-profit association that was established ... education and implementation of solutions that protect and ... ...
(Date:6/4/2015)... 2015  Today, the co-chairs of the Blue Ribbon Study ... biocontainment labs and USA Today,s ... concerns over the findings of lax safety standards and called ... "The state ... said Joe Lieberman , former senator and co-chair of ...
(Date:6/1/2015)... 1, 2015 According to ... Market by Application (Government, Military & Defense, Healthcare, ... and Security), Technology (Face Recognition, Fingerprint Recognition, Iris ... Recognition, and Others), Function (Contact and Non-Contact) & ... Europe , APAC, Row) - Global ...
Breaking Biology News(10 mins):Secure Identity & Biometrics Association (SIBA) Names Troy Potter of L-3 National Security Solutions as Chairman 2Secure Identity & Biometrics Association (SIBA) Names Troy Potter of L-3 National Security Solutions as Chairman 3Secure Identity & Biometrics Association (SIBA) Names Troy Potter of L-3 National Security Solutions as Chairman 4Secure Identity & Biometrics Association (SIBA) Names Troy Potter of L-3 National Security Solutions as Chairman 5Biodefense Panel Expresses Grave Concerns over Findings at Nation's Research Labs 2Biodefense Panel Expresses Grave Concerns over Findings at Nation's Research Labs 3Next Generation Biometrics Market Worth $24,448.84 Million by 2020 2Next Generation Biometrics Market Worth $24,448.84 Million by 2020 3Next Generation Biometrics Market Worth $24,448.84 Million by 2020 4
... In the largest clinical trial to date to examine ... carriers with diseases other than breast and ovarian cancer, ... against advanced pancreatic and prostate cancers. Results of the ... Medicine at the University of Pennsylvania and Sheba Medical ...
... Ocean frontier explorer and world-renowned filmmaker James Cameron has ... San Diego as the recipient of the 2013 Nierenberg ... deliver a presentation on his record-setting DEEPSEA CHALLENGE expedition ... on Friday, May 31, on the UC San Diego ...
... have developed guidelines being used by foresters and the ... when planting trees., Maps developed by Laura Gray, a ... projections of climatically suitable habitat for tree species based ... , The work, published recently in the journal ...
Cached Biology News:PARP inhibitor shows activity in pancreatic, prostate cancers among patients carrying BRCA mutations 2James Cameron to be publicly honored with Scripps Nierenberg Prize 2James Cameron to be publicly honored with Scripps Nierenberg Prize 3James Cameron to be publicly honored with Scripps Nierenberg Prize 4
(Date:6/29/2015)... 2015  AACC, a global scientific and medical ... medicine, is pleased to announce that the impact ... has increased to 7.9 in the 2014 Thomson ... Clinical Chemistry in the top 3% of ... of the research it publishes on laboratory medicine ...
(Date:6/29/2015)... ... 29, 2015 , ... The StampedeCon 2015 Big Data Conference will ... in a row, will bring top technology professionals to St. Louis. Top industry speakers ... data and technology. The event is proudly sponsored by DataStax, Cisco, World Wide Technology, ...
(Date:6/26/2015)... , June 26, 2015  SeraCare Life Sciences, ... manufacturers, today announced that it has signed a ... National Cancer Institute (NCI), part of the National ... positive controls for cancer assays.  The CRADA will ... accurately quantitate control DNA biosynthetics spiked into a ...
(Date:6/26/2015)... June 26, 2015  A San Francisco company, Pembient, ... with synthetic rhino horn: beer in China ... . In response to the emerging industry, two ... and sale of synthetic rhino horn.  ... Save the Rhino International (SRI) released a ...
Breaking Biology Technology:AACC's Journal, Clinical Chemistry, Continues to Have Significant Impact on Medical Testing, Healthcare 2AACC's Journal, Clinical Chemistry, Continues to Have Significant Impact on Medical Testing, Healthcare 3StampedeCon Announces 2015 Agenda 2StampedeCon Announces 2015 Agenda 3SeraCare Life Sciences Signs CRADA with NCI to Advance Cancer Diagnostics 2SeraCare Life Sciences Signs CRADA with NCI to Advance Cancer Diagnostics 3Rhino Experts Oppose Synthetic Rhino Horn as Solution to Poaching Crisis 2
... engineers across Wisconsin are learning new ways to ... sugars, soybeans, solar collectors, corn stover, wind farms, ... , ,State businesses, architects, and builders are national ... save energy and money. , ,Wisconsin policymakers and ...
... after the launch of wireless Internet service in downtown Madison, ... service offered by area coffee shops. , ,Now, Mad ... 10-block radius of Madison's Capitol Square and at Dane ... of them. The broadband service will add indoor wireless access ...
Whitewater, Wis . - Sharon Ethanol , a subsidiary of <a...
Cached Biology Technology:Wisconsin can offer what a federal energy research lab needs 2Wisconsin can offer what a federal energy research lab needs 3Wisconsin can offer what a federal energy research lab needs 4