Navigation Links
Children's Hospital scientists achieve repair of injured heart muscle in lab tests of stem cells
Date:11/25/2008

Researchers at Children's Hospital of Pittsburgh of UPMC have been able to effectively repair damaged heart muscle in an animal model using a novel population of stem cells they discovered that is derived from human skeletal muscle tissue.

The research team led by Johnny Huard, PhD transplanted stem cells purified from human muscle-derived blood vessels into the hearts of mice that had heart damage similar to that which would occur in people who had suffered a heart attack.

These transplanted myoendothelial cells repaired the injured muscle, stimulated the growth of new blood vessels in the heart and reduced scar tissue from the injury, thereby dramatically improving the function of the injured left ventricle, said Dr. Huard, director of the Stem Cell Research Center at Children's Hospital's John G. Rangos Sr. Research Center.

"This study confirms our belief that this novel population of stem cells discovered in our laboratory holds tremendous promise for the future of regenerative medicine. Specifically, myoendothelial cells show potential as a therapy for people who have suffered a myocardial infarction," said Dr. Huard, also the Henry J. Mankin Professor and vice chair for research in the Department of Orthopaedic Surgery, University of Pittsburgh School of Medicine. "The important benefit of our approach is that as a therapy, it would be an autologous transplant. This means that for a patient who suffers a heart attack, we would take a muscle biopsy from his or her muscle, isolate and purify the myoendothelial cells, and re-inject them into the injured heart muscle, thereby avoiding any risk of rejection by introducing foreign cells."

Results of this study are published in the Dec. 2 issue of the Journal of the American College of Cardiology.

The myoendothelial cells used in this study were more effective at repairing the injured cardiac muscle and reducing scar tissue than previous approaches that have used muscle cells known as myoblasts, according to Dr. Huard. At six weeks after injection, the myoendothelial cell-injected hearts functioned at 40 to 50 percent more effectively compared with hearts that had been injected with myogenic cells (myoblasts).


'/>"/>

Contact: Marc Lukasiak
marc.lukasiak@chp.edu
412-692-7919
Children's Hospital of Pittsburgh
Source:Eurekalert

Related biology news :

1. Rhode Island Hospital simulation center examines benefits and applications of medical simulation
2. First results from hospital trials testing
3. Field-hospital-on-a-chip project awarded to nanoengineer from UC San Diego
4. Brown University and Women & Infants Hospital expand national childrens study to Bristol County
5. Childrens Hospital researchers identify genetic mutation that may predict organ rejection
6. Rhode Island Hospital study finds link between obesity, type 2 diabetes and neurodegeneration
7. Childrens Memorial Hospital of Chicago receives a grant from BioMarin to support adult PKU outreach
8. Montreal Heart Institute and Mount Sinai Hospital researchers contribute to Crohns disease study
9. Childrens Hospital leads projects to develop nations first heart assist devices for young children
10. Clinical trial that may help patients breathe easier begins at Central DuPage Hospital
11. MRSA in hospital intensive care -- whats growing where?
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/23/2017)... Research and Markets has announced the addition ... - Industry Forecast to 2025" report to their offering. ... The Global Vehicle ... around 8.8% over the next decade to reach approximately $14.21 billion ... estimates and forecasts for all the given segments on global as ...
(Date:3/20/2017)... 20, 2017 PMD Healthcare announces the release ... Wellness Management System (WMS), a remote, real-time lung health ... PMD Healthcare is a Medical Device, Digital Health, and ... to creating innovative solutions that empower people to improve ... focus, PMD developed the first ever personal spirometer, Spiro ...
(Date:3/7/2017)... , March 7, 2017 Brandwatch , the leading ... The Prince,s Trust to uncover insights to support its ... Trust. The UK,s leading youth charity will be using ... results and get a better understanding of the topics and issues ... ...
Breaking Biology News(10 mins):
(Date:3/28/2017)... ... March 28, 2017 , ... Triumph Modular Incorporated, and manufacturing ... an international modular trade organization, were awarded First Place, as well as the ... Lab at Harvard University. The awards were presented at the 34th Annual World ...
(Date:3/28/2017)... , Belgium , March 28, 2017 /PRNewswire/ ... Limited (NYSE MKT: VNRX), today announced the engagement of ... Associates, LLC, as a strategic consultant. Dr. Vollmer Dahlke,s ... and securing non-dilutive funding in the State of ... States . Dr. Vollmer Dahlke has significant ...
(Date:3/28/2017)... 2017 Dr. Chris Yu , ... Anpac Bio-Medical Science Company , announced this ... processing and reporting over 40,000 cases worldwide of ... liquid biopsy tests. Described as ... publications, Anpac Bio,s CDA medical devices and technology ...
(Date:3/28/2017)... NC (PRWEB) , ... March 28, 2017 , ... ... side effects and diminished effectiveness over time. A recent study published in STEM ... PD by stimulating subventricular zone (SVZ) stem cells to produce more neural cells. ...
Breaking Biology Technology: